Working Memory and Choice Encoding in Medial Prefrontal Cortex of Rats Performing a Spatial Double Alternation Task PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Working Memory and Choice Encoding in Medial Prefrontal Cortex of Rats Performing a Spatial Double Alternation Task PDF full book. Access full book title Working Memory and Choice Encoding in Medial Prefrontal Cortex of Rats Performing a Spatial Double Alternation Task by Mathew Leonard. Download full books in PDF and EPUB format.
Author: Mathew Leonard Publisher: ISBN: Category : Languages : en Pages : 45
Book Description
Neural correlates of working memory, errors, and response choice were identified in the medial prefrontal cortex (mPFC) of rats performing a spatial delayed double alternation task. The mPFC of rats has been associated with attention, working memory, emotional control, and other executive functions. Lesioning or inactivation of mPFC, the prelim- bic (PL) and infralimbic (IL) areas in particular, have been shown to produce significance decreases in performance of delayed response tasks. Previous recording experiments have found examples of neurons in mPFC that have elevated and selective activity during the delay period. However, these experiments have been quite simple compared to experiments in monkeys. For instance, many experiments in rats have used spatial alternation tasks but none have been able to successfully separate coding for past spatial goals from coding for future spatial goals. The aim of the experiment reported here was to develop a task with complexity similar to what is found in primate research and to record from mPFC as the rats performed the task. We developed a delayed double alternation, in which rats must respond in a left-left-right-right pattern. This task requires the rats to store and recall at least two items of information to receive rewards. After training rats to perform the task, we recorded from mPFC of awake behaving rats using chronically implanted tetrodes. We found groups of neurons encoding past goals, future goals, switch-stay strategy, and response errors. Encoding for past goals and future goals are performed by two separate, but over- lapping, ensembles of neurons. Anatomically, the mPFC is involved in neural circuits which serve to integrate internal and external stimuli into behavioral actions. Our results reveal a functional integration of the past, present, and future into action.
Author: Mathew Leonard Publisher: ISBN: Category : Languages : en Pages : 45
Book Description
Neural correlates of working memory, errors, and response choice were identified in the medial prefrontal cortex (mPFC) of rats performing a spatial delayed double alternation task. The mPFC of rats has been associated with attention, working memory, emotional control, and other executive functions. Lesioning or inactivation of mPFC, the prelim- bic (PL) and infralimbic (IL) areas in particular, have been shown to produce significance decreases in performance of delayed response tasks. Previous recording experiments have found examples of neurons in mPFC that have elevated and selective activity during the delay period. However, these experiments have been quite simple compared to experiments in monkeys. For instance, many experiments in rats have used spatial alternation tasks but none have been able to successfully separate coding for past spatial goals from coding for future spatial goals. The aim of the experiment reported here was to develop a task with complexity similar to what is found in primate research and to record from mPFC as the rats performed the task. We developed a delayed double alternation, in which rats must respond in a left-left-right-right pattern. This task requires the rats to store and recall at least two items of information to receive rewards. After training rats to perform the task, we recorded from mPFC of awake behaving rats using chronically implanted tetrodes. We found groups of neurons encoding past goals, future goals, switch-stay strategy, and response errors. Encoding for past goals and future goals are performed by two separate, but over- lapping, ensembles of neurons. Anatomically, the mPFC is involved in neural circuits which serve to integrate internal and external stimuli into behavioral actions. Our results reveal a functional integration of the past, present, and future into action.
Author: Federico Bermudez-Rattoni Publisher: CRC Press ISBN: 1420008412 Category : Psychology Languages : en Pages : 368
Book Description
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Author: Dori Derdikman Publisher: Springer ISBN: 3709112923 Category : Medical Languages : en Pages : 567
Book Description
The discovery of new cell types, such as grid and time cells, in the hippocampus has been accompanied by major anatomical and theoretical insights in the recent years. This book provides comprehensive, up-to-date information about the hippocampal formation and especially the neural basis of episodic memory, spatial location (the formation of the cognitive map) and temporal representation. The first part of the book describes the information flow from pre-hippocampal areas into the hippocampus, the second part discusses the different types of hippocampal processing and finally, the third part depicts the influence that the hippocampal processing has on other brain structures that are perhaps more closely tied to explicit cognitive or behavioral output. This book is intended for neuroscientists, especially for those who are involved in research on the hippocampus, as well as for behavioral scientists and neurologists.
Author: Kishan Gupta Publisher: ISBN: Category : Languages : en Pages : 362
Book Description
Abstract: The medial entorhinal cortex (MEC) contains spatial cell types including grid and head direction (HD) cells. Grid cells fire action potentials when animals pass through environmental locations that form vertices of tessellating triangles. HD cells fire when animals face a preferred direction along their azimuth. These cells have been widely studied for their potential metric role in spatial navigation, but considerably less is known about their non-metric functions. This thesis examines non-metric influences on the MEC during working memory maintenance, 'look-ahead' activity, and 'more familiar' or 'less familiar' environmental rotations.The first experiment tests the hypothesis that persistent spiking of MEC neurons could represent a sensory cue during a working memory task. Animals ran a T-Maze where an auditory stimulus cued rats to move toward left- or right-reward arms. Instead of the hypothesized increase in spike rate during the delay period between cue and reward, MEC spike rates were suppressed. Additionally, MEC ensemble firing at the choice point suggests that these cells encoded reward locations. This indicates the MEC displays forward activation of possible future locations ('look-ahead' activity).To model this experiment's look-ahead results, a recent model of goal-directed navigation was adapted to the previous T-Maze task. This adaptation trains a virtual rat to associate cues to reward cells and corresponding place cells, a difference from previous models where goal locations were not cue-associated. The rat reliably learns goal locations, performs look-ahead scans at the choice point, and simulated MEC activity decodes to reward locations, successfully modeling look-ahead behavior.The final experiment examines effects of environmental recency on spatial tuning of MEC neurons. Rats performed spatial alternation on a T-Maze rotated into 'more familiar' or 'less familiar' configurations as MEC units were recorded. Spatial cells oriented their firing fields in register with the T-Maze more often during less familiar rotations. This implies a shift in animals' reference frame with learned experience suggesting the MEC is comparing contexts in the same environment.In summary, these results highlight previously uninvestigated, non-metric influences over MEC activity with strong implications for goal-directed behavior and spatial navigation.
Author: Sheri J.Y. Mizumori Publisher: Oxford University Press ISBN: 0198043457 Category : Medical Languages : en Pages : 431
Book Description
Data from neuropsychological and animal research suggest that the hippocampus plays a pivotal role in two relatively different areas: active navigation, as well as episodic learning and memory. Recent studies have attempted to bridge these disparate accounts of hippocampal function by emphasizing the role that hippocampal place cells may play in processing the spatial contextual information that defines situations in which learned behaviors occur. A number of established laboratories are currently offering complementary interpretations of place fields, and this book will present the first common platform for them. Bringing together research from behavioral, genetic, physiological, computational, and neural-systems perspectives will provide a thorough understanding of the extent to which studying place-field properties has informed our understanding of the neural mechanisms of hippocampus-dependent memory. Hippocampal Place Fields: Relevance to Learning and Memory will serve as a valuable reference for everyone interested in hippocampal function.
Author: Naoyuki Osaka Publisher: ISBN: 0198570392 Category : Philosophy Languages : en Pages : 418
Book Description
It is only relatively recently that it has been possible to study the neural processes that might underlie working memory, leading to a proliferation of research in this domain. This volume brings together leading researchers from around the world to summarise current knowledge of this field.
Author: A. David Redish Publisher: MIT Press ISBN: 9780262181945 Category : Animal navigation Languages : en Pages : 452
Book Description
There are currently two major theories about the role of the hippocampus, a distinctive structure in the back of the temporal lobe. One says that it stores a cognitive map, the other that it is a key locus for the temporary storage of episodic memories. A. David Redish takes the approach that understanding the role of the hippocampus in space will make it possible to address its role in less easily quantifiable areas such as memory. Basing his investigation on the study of rodent navigation--one of the primary domains for understanding information processing in the brain--he places the hippocampus in its anatomical context as part of a greater functional system. Redish draws on the extensive experimental and theoretical work of the last 100 years to paint a coherent picture of rodent navigation. His presentation encompasses multiple levels of analysis, from single-unit recording results to behavioral tasks to computational modeling. From this foundation, he proposes a novel understanding of the role of the hippocampus in rodents that can shed light on the role of the hippocampus in primates, explaining data from primate studies and human neurology. The book will be of interest not only to neuroscientists and psychologists, but also to researchers in computer science, robotics, artificial intelligence, and artificial life.
Author: Mathew Leonard
Author: Mathew Leonard
Author: Joaquin M. Fuster
Author: Nicole Kristen Horst
Author: Federico Bermudez-Rattoni
Author: Dori Derdikman
Author: Kishan Gupta
Author: Sheri J.Y. Mizumori
Author: VOGT
Author: Naoyuki Osaka
Author: A. David Redish