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Author: Claudia Gonzaga-Jauregui Publisher: Academic Press ISBN: 0128204362 Category : Medical Languages : en Pages : 318
Book Description
Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. - Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes - Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions - Explores opportunities for novel therapeutics - Features chapter contributions from leading researchers and clinicians
Author: Claudia Gonzaga-Jauregui Publisher: Academic Press ISBN: 0128204362 Category : Medical Languages : en Pages : 318
Book Description
Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. - Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes - Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions - Explores opportunities for novel therapeutics - Features chapter contributions from leading researchers and clinicians
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309055342 Category : Medical Languages : en Pages : 497
Book Description
How do communities protect and improve the health of their populations? Health care is part of the answer but so are environmental protections, social and educational services, adequate nutrition, and a host of other activities. With concern over funding constraints, making sure such activities are efficient and effective is becoming a high priority. Improving Health in the Community explains how population-based performance monitoring programs can help communities point their efforts in the right direction. Within a broad definition of community health, the committee addresses factors surrounding the implementation of performance monitoring and explores the "why" and "how to" of establishing mechanisms to monitor the performance of those who can influence community health. The book offers a policy framework, applies a multidimensional model of the determinants of health, and provides sets of prototype performance indicators for specific health issues. Improving Health in the Community presents an attainable vision of a process that can achieve community-wide health benefits.
Author: Janet Amundson Romich Publisher: Veterinary Technology ISBN: 9781418021030 Category : Medical Languages : en Pages : 701
Book Description
Understanding Zoonotic Diseases is written for both animal and human healthcare professionals and students that will help them understand specific zoonotic diseases. Designed as a stand-alone book, it introduces the reader to microbes including bacteria, fungi, parasites, viruses, and prions, and describes specific diseases that can be transmitted from animals to humans. Extensive use of images, photographs, tables, and clinically relevant comments helps the reader understand the role of animals in causing diseases in humans. Review questions at the end of each chapter and online critical thinking questions help the learner gain a deeper understanding of the material and aid in retention.
Author: Jules J. Berman Publisher: Academic Press ISBN: 0124200095 Category : Medical Languages : en Pages : 407
Book Description
Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases. Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease. This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common. - Makes rare diseases relevant to clinicians and researchers by tying lessons learned about the rare diseases to our understanding of the common diseases - Stresses basic pathologic mechanisms that account for human disease (e.g., disorders of cell development, replication, maintenance, function and structure), that can be understood without prior training in pathology - Discusses advanced concepts in molecular biology and genetics in a simple, functional context appropriate for medical trainees and new researchers - Offers insights into how further research into rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases
Author: Hugh C. Rayner Publisher: Springer ISBN: 9783030430269 Category : Medical Languages : en Pages : 398
Book Description
This book combines the reference material of a nephrology textbook with the everyday relevance of a clinical handbook. This second edition develops and expands upon the success of the first. All the content has been updated and entirely new chapters on acid-base disorders and stone disease have been added. Understanding Kidney Diseases includes over 60 real-life case studies and is illustrated with over 200 figures. Readers can test their knowledge with a bank of multiple-choice questions and put it into practice by answering questions that patients frequently ask. The book provides all that students, residents and fellows need in order to approach a patient with a kidney problem with confidence.
Author: Moises Velasquez-Manoff Publisher: Simon and Schuster ISBN: 1439199396 Category : Biography & Autobiography Languages : en Pages : 416
Book Description
A controversial, revisionist approach to autoimmune and allergic disorders considers the perspective that the human immune system has been disabled by twentieth-century hygiene and medical practices.
Author: Raymond DiGiuseppe Publisher: Oxford University Press ISBN: 0195170792 Category : Family & Relationships Languages : en Pages : 433
Book Description
Since classical times, philosophers and physicians have identified anger as a human frailty that can lead to violence and human suffering, but with the development of a modern science of abnormal psychology and mental disorders, it has been written off as merely an emotional symptom and excluded from most accepted systems of psychiatric diagnosis. Yet despite the lack of scientific recognition, anger-related violence is often in the news, and courts are increasingly mandating anger management treatment. It is time for a fresh scientific examination of one of the most fundamental human emotions and what happens when it becomes pathological, and this thorough, persuasive book offers precisely such a probing analysis.Using both clinical data and a variety of case studies, esteemed anger researchers Raymond A. DiGiuseppe and Raymond Chip Tafrate argue for a new diagnostic classification, Anger Regulation and Expression Disorder, that will help bring about clinical improvements and increased scientific understanding of anger. After situating anger in both historical and emotional contexts, they report research that supports the existence of several subtypes of the disorder and review treatment outcome studies and new interventions to improve treatment. The first book that fully explores anger as a clinical phenomenon and provides a reliable set of assessment criteria, it represents a major step toward establishing the clear definitions and scientific basis necessary for assessing, diagnosing, and treating anger disorders.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309158060 Category : Medical Languages : en Pages : 442
Book Description
Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.
Author: Claudia Gonzaga-Jauregui
Author: Claudia Gonzaga-Jauregui
Author: Institute of Medicine
Author: Madeline Drexler
Author: Janet Amundson Romich
Author: Jules J. Berman
Author: Hugh C. Rayner
Author: Moises Velasquez-Manoff
Author: Raymond DiGiuseppe
Author: Henk Lamberts
Author: Institute of Medicine