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Author: Caleb Daniel Martin Publisher: ISBN: Category : Languages : en Pages : 270
Book Description
The chemistry of the main group elements with nitrogen based ligands has been an area that has received little attention in comparison to transition metals. The preliminary investigations have focused on groups 13 and 14 revealing new bonding motifs and interesting reactivity. This has motivated us to synthesize group 15 and 16 derivatives in new bonding arrangements capable of activating small molecules. In pursuit of isolating such species, the reactivity of sulfur dichloride and S(OTf)2 with a series of diazabutadiene (DAB) ligands was explored. The substitution on the ligand was extremely influential on the outcome of the reaction. Alkyl groups on the nitrogen atom resulted in the production of 1,2,5-thiadiazolium heterocycles by loss of an alkyl group whereas methyl groups on the backbone carbon atom led to reaction with the eneamine tautomer of the ligand to give N, C-bound heterocycles. This could be avoided with aryl groups or hydrogen atoms on the backbone carbons and aryl groups on the nitrogen centres. The latter reactions produced dicationic analogues of the N-Heterocyclic carbene, the first examples for sulfur. The chemistry of the chalcogen halides and bistriflate synthons with the diiminopyridine (DIMPY) ligand showed similar trends. Methyl groups on the backbone carbon resulted in bonding through a methyl carbon whereas phenyl groups or hydrogen atoms in the same position produced N, N', N''-chelated cations or dications. The dicationic triflate salts are stable in the open atmosphere, a remarkable feature for highly charged cations. The chemistry was also extended to phosphorus. Collectively these species represent the first DIMPY complexes for phosphorus, sulfur, selenium and tellurium. Sulfur(II) dications with amine donors, namely pentamethyldiethylenetriamine could also be prepared. The complex was highly unstable indicating imine and pyridine groups offer greater stabilization. In addition to the chelate complexes, monodentate pyridine ligands coordinate to a dicationic sulfur centre. The monodentate species displayed reactivity with a variety of unsaturated organic substrates. Altering the group on the para position of the pyridine proved to have a significant effect on the reactivity indicating potential tuneability for the system.
Author: Caleb Daniel Martin Publisher: ISBN: Category : Languages : en Pages : 270
Book Description
The chemistry of the main group elements with nitrogen based ligands has been an area that has received little attention in comparison to transition metals. The preliminary investigations have focused on groups 13 and 14 revealing new bonding motifs and interesting reactivity. This has motivated us to synthesize group 15 and 16 derivatives in new bonding arrangements capable of activating small molecules. In pursuit of isolating such species, the reactivity of sulfur dichloride and S(OTf)2 with a series of diazabutadiene (DAB) ligands was explored. The substitution on the ligand was extremely influential on the outcome of the reaction. Alkyl groups on the nitrogen atom resulted in the production of 1,2,5-thiadiazolium heterocycles by loss of an alkyl group whereas methyl groups on the backbone carbon atom led to reaction with the eneamine tautomer of the ligand to give N, C-bound heterocycles. This could be avoided with aryl groups or hydrogen atoms on the backbone carbons and aryl groups on the nitrogen centres. The latter reactions produced dicationic analogues of the N-Heterocyclic carbene, the first examples for sulfur. The chemistry of the chalcogen halides and bistriflate synthons with the diiminopyridine (DIMPY) ligand showed similar trends. Methyl groups on the backbone carbon resulted in bonding through a methyl carbon whereas phenyl groups or hydrogen atoms in the same position produced N, N', N''-chelated cations or dications. The dicationic triflate salts are stable in the open atmosphere, a remarkable feature for highly charged cations. The chemistry was also extended to phosphorus. Collectively these species represent the first DIMPY complexes for phosphorus, sulfur, selenium and tellurium. Sulfur(II) dications with amine donors, namely pentamethyldiethylenetriamine could also be prepared. The complex was highly unstable indicating imine and pyridine groups offer greater stabilization. In addition to the chelate complexes, monodentate pyridine ligands coordinate to a dicationic sulfur centre. The monodentate species displayed reactivity with a variety of unsaturated organic substrates. Altering the group on the para position of the pyridine proved to have a significant effect on the reactivity indicating potential tuneability for the system.
Author: Astrid Sigel Publisher: Springer Science & Business Media ISBN: 9400721722 Category : Science Languages : en Pages : 386
Book Description
Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.
Author: Alberto Pais Publisher: Elsevier ISBN: 0323972519 Category : Medical Languages : en Pages : 298
Book Description
Artificial Intelligence for Drug Product Lifecycle Applications explains the use of artificial intelligence (AI) in drug discovery and development paths, including the clinical and postapproval phases. This book gives methods for each of the drug development steps, from the fundamentals to postapproval drug product. AI is a synergistic assembly of enhanced optimization strategies with particular applications in pharmaceutical development and advanced tools for promoting cost-effectiveness throughout the drug lifecycle. Specifically, AI brings together the potential to improve drug approval rates, reduce development costs, get medications to patients faster, and help patients comply with their treatments. Accelerated pharmaceutical development and drug product approval rates will enable larger profits from patent-protected market exclusivity. This book offers the tools and knowledge to create the right AI strategy to extend the landscape of AI applications across the drug lifecycle. It is especially useful for pharmaceutical scientists, health care professionals, and regulatory scientists, as well as advanced students and postgraduates actively involved in pharmaceutical product and process development involving the use of artificial intelligence in drug delivery applications. Classifies AI methodologies and application examples into different categories representing the various steps of the drug development cycle Combines timely literature review with clear artworks to improve understanding Examines deep learning and machine learning in drug discovery
Author: David Scheschkewitz Publisher: Springer ISBN: 331903734X Category : Science Languages : en Pages : 239
Book Description
The series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves. Issues associated with the development of bonding models and generalizations that illuminate the reactivity pathways and rates of chemical processes are also relevant. The individual volumes in the series are thematic. The goal of each volume is to give the reader, whether at a university or in industry, a comprehensive overview of an area where new insights are emerging that are of interest to a larger scientific audience. Thus each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years should be presented using selected examples to illustrate the principles discussed. A description of the physical basis of the experimental techniques that have been used to provide the primary data may also be appropriate, if it has not been covered in detail elsewhere. The coverage need not be exhaustive in data, but should rather be conceptual, concentrating on the new principles being developed that will allow the reader, who is not a specialist in the area covered, to understand the data presented. Discussion of possible future research directions in the area is welcomed. Review articles for the individual volumes are invited by the volume editors. Readership: research scientists at universities or in industry, graduate students Special offer for all customers who have a standing order to the print version of Structure and Bonding, we offer free access to the electronic volumes of the Series published in the current year via SpringerLink.
Author: Kenneth Berendzen Publisher: Bentham Science Publishers ISBN: 1608054926 Category : Science Languages : en Pages : 225
Book Description
A major goal of integrative research is understanding regulatory networks to such an extent as to allow researchers to model developmental and stress responses. Regulatory networks of living systems include complex and vast interactions between proteins, metabolites, RNA, various signaling molecules and DNA. One aspect of systems biology is understanding the dynamics of protein-DNA interactions affecting gene expression that are caused by transcription factors (TFs) and chromatin remodeling factors. This e-book provides a resource for summarizing current knowledge eukaryotic transcription and explores cis-elements and methods for their analysis, prediction and discovery. The book also presents an overview of exploring gene regulatory networks, chromatin, and miRNAs. Information about state-of-the-art techniques for the determination of TF - cis-element interactions in vivo and in silico give cutting edge insights on how genomic-scale research is being approached. The Analysis of Regulatory DNA provides readers with both the necessary background knowledge and provocative, up-to-date insights aimed at sparking new and vibrant experimental designs for understanding and predicting cis-elements in the eukaryotic genome.
Author: Emilio M. Pérez Publisher: John Wiley & Sons ISBN: 3527828966 Category : Science Languages : en Pages : 309
Book Description
Mechanically Interlocked Materials Comprehensive one-stop resource on the emerging world of mechanically interlocked materials (MIMats) Mechanically Interlocked Materials provides a thorough overview of the new emerging field in supramolecular chemistry. Edited by one of the leading researchers in the field, Mechanically Interlocked Materials includes information on: Types of MIMats, such as metal organic frameworks, polymers, carbon nanotubes, nanoparticles, and others Main advantages/disadvantages of the mechanical bond of MIMats with respect to covalent or supramolecular alternatives Mechanically interlocked (MI) electronics, molecular materials, nano and micro particles, nucleic acids, and proteins Force in MIMs, MIMs on surfaces, polycatenanes, sliding ring gels, and potential applications of MIMats as molecular switches and binary materials With comprehensive coverage of an important emerging field, Mechanically Interlocked Materials is an essential resource for students and professionals in a variety of scientific fields, including organic, inorganic, supramolecular, and physical chemistry, physics, materials science, and nanotechnology.
Author: Tong Li Publisher: John Wiley & Sons ISBN: 1119046343 Category : Science Languages : en Pages : 578
Book Description
An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.
Author: Mark Stradiotto Publisher: John Wiley & Sons ISBN: 1118839773 Category : Science Languages : en Pages : 448
Book Description
The design of ancillary ligands used to modify the structural and reactivity properties of metal complexes has evolved into a rapidly expanding sub-discipline in inorganic and organometallic chemistry. Ancillary ligand design has figured directly in the discovery of new bonding motifs and stoichiometric reactivity, as well as in the development of new catalytic protocols that have had widespread positive impact on chemical synthesis on benchtop and industrial scales. Ligand Design in Metal Chemistry presents a collection of cutting-edge contributions from leaders in the field of ligand design, encompassing a broad spectrum of ancillary ligand classes and reactivity applications. Topics covered include: Key concepts in ligand design Redox non-innocent ligands Ligands for selective alkene metathesis Ligands in cross-coupling Ligand design in polymerization Ligand design in modern lanthanide chemistry Cooperative metal-ligand reactivity P,N Ligands for enantioselective hydrogenation Spiro-cyclic ligands in asymmetric catalysis This book will be a valuable reference for academic researchers and industry practitioners working in the field of ligand design, as well as those who work in the many areas in which the impact of ancillary ligand design has proven significant, for example synthetic organic chemistry, catalysis, medicinal chemistry, polymer science and materials chemistry.
Author: N. Sneha Vasundara Publisher: Notion Press ISBN: Category : Fiction Languages : en Pages : 180
Book Description
In "Unveiling Bonds: Journeys of Love, Truth, and Family" Saraswati's life unfurls amidst societal expectations and the weight of tradition. As she treads the tightrope between individual dreams and familial duty, a shadowy secret from the past engulfs her world. Rishi, the man at the epicenter of this whirlwind, faces revelations that challenge everything he believed in. But when heartache, betrayal, and an unquenchable thirst for vengeance converge, can they find redemption? Dive deep into a narrative that unravels the intricate dance of love, choices, and consequence, set against the vibrant backdrop of modern India. With suspense that grips and emotions that tug, "Unveiling Bonds: Journeys of Love, Truth, and Family" is a poignant journey through dreams deferred, promises broken, and the enduring spirit of hope.
Author: Caleb Daniel Martin
Author: Caleb Daniel Martin
Author: Astrid Sigel
Author: Alberto Pais
Author: David Scheschkewitz
Author: Dacher Keltner
Author: Kenneth Berendzen
Author: Emilio M. Pérez
Author: Tong Li
Author: Mark Stradiotto
Author: N. Sneha Vasundara