Transparent Graphene Neural Electrodes and Field-effect Transistors for Bio Applications PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Transparent Graphene Neural Electrodes and Field-effect Transistors for Bio Applications PDF full book. Access full book title Transparent Graphene Neural Electrodes and Field-effect Transistors for Bio Applications by Dong-Wook Park. Download full books in PDF and EPUB format.
Author: Dong-Wook Park Publisher: ISBN: Category : Languages : en Pages : 116
Book Description
Graphene, a novel material made of carbon atoms, has broad wavelength transparency from ultraviolet (UV) to infrared (IR). In addition, the electrical conductivity, mechanical flexibility, and biocompatibility of graphene make it a promising material for next-generation biomedical devices and biosensors. Among various applications of graphene, transparent graphene neural electrodes and graphene field-effect transistors have been studied. A transparent, flexible, and implantable graphene neural electrode array (or simply graphene brain sensor) that is capable of advanced in vivo neural imaging, electrophysiological recordings, optogenetics, and electrical stimulation has been demonstrated. Previous in vivo studies with conventional metal-based electrodes were limited to monitoring the tissue surrounding the electrode sites due to the opaqueness of the metal. Optical stimuli through the electrode sites and traces were also impossible with metal electrodes. The transparent graphene brain sensor implanted over the cerebral cortex in laboratory rodents allowed for chronic investigation of the underlying neural tissue while simultaneously performing electrophysiology. In vivo imaging of the cortical vasculature through the transparent brain sensor has been shown via fluorescence microscopy and 3D optical coherence tomography. Optogenetic activation of focal cortical areas directly beneath the electrode sites has been demonstrated in transgenic Thy1::ChR2 mice. In order to understand the working mechanism of the graphene electrodes and to expand their utility, the electrochemical impedance of the graphene electrode arrays and their demonstration to the electrical stimulation in GCaMP6 mice have been studied. In addition, graphene field-effect transistors (FETs) with a bottom-gate structure either on a rigid or flexible substrate (Parylene C) have been demonstrated. First, for the purpose of minimizing process-induced mobility degradation of graphene, graphene radio frequency (RF) transistors with buried bottom gates have been fabricated and characterized. Second, the fabrication, characterization, and performance improvement of flexible bottom-gate graphene transistors on Parylene C have been discussed. For all of the graphene FETs introduced here, the graphene transferred on top of the devices could be used as a bio sensing material. This study demonstrates an array of abilities of graphene neural electrodes and graphene FETs.
Author: Dong-Wook Park Publisher: ISBN: Category : Languages : en Pages : 116
Book Description
Graphene, a novel material made of carbon atoms, has broad wavelength transparency from ultraviolet (UV) to infrared (IR). In addition, the electrical conductivity, mechanical flexibility, and biocompatibility of graphene make it a promising material for next-generation biomedical devices and biosensors. Among various applications of graphene, transparent graphene neural electrodes and graphene field-effect transistors have been studied. A transparent, flexible, and implantable graphene neural electrode array (or simply graphene brain sensor) that is capable of advanced in vivo neural imaging, electrophysiological recordings, optogenetics, and electrical stimulation has been demonstrated. Previous in vivo studies with conventional metal-based electrodes were limited to monitoring the tissue surrounding the electrode sites due to the opaqueness of the metal. Optical stimuli through the electrode sites and traces were also impossible with metal electrodes. The transparent graphene brain sensor implanted over the cerebral cortex in laboratory rodents allowed for chronic investigation of the underlying neural tissue while simultaneously performing electrophysiology. In vivo imaging of the cortical vasculature through the transparent brain sensor has been shown via fluorescence microscopy and 3D optical coherence tomography. Optogenetic activation of focal cortical areas directly beneath the electrode sites has been demonstrated in transgenic Thy1::ChR2 mice. In order to understand the working mechanism of the graphene electrodes and to expand their utility, the electrochemical impedance of the graphene electrode arrays and their demonstration to the electrical stimulation in GCaMP6 mice have been studied. In addition, graphene field-effect transistors (FETs) with a bottom-gate structure either on a rigid or flexible substrate (Parylene C) have been demonstrated. First, for the purpose of minimizing process-induced mobility degradation of graphene, graphene radio frequency (RF) transistors with buried bottom gates have been fabricated and characterized. Second, the fabrication, characterization, and performance improvement of flexible bottom-gate graphene transistors on Parylene C have been discussed. For all of the graphene FETs introduced here, the graphene transferred on top of the devices could be used as a bio sensing material. This study demonstrates an array of abilities of graphene neural electrodes and graphene FETs.
Author: Omar Azzaroni Publisher: John Wiley & Sons ISBN: 3527843388 Category : Technology & Engineering Languages : en Pages : 453
Book Description
Graphene Field-Effect Transistors In-depth resource on making and using graphene field effect transistors for point-of-care diagnostic devices Graphene Field-Effect Transistors focuses on the design, fabrication, characterization, and applications of graphene field effect transistors, summarizing the state-of-the-art in the field and putting forward new ideas regarding future research directions and potential applications. After a review of the unique electronic properties of graphene and the production of graphene and graphene oxide, the main part of the book is devoted to the fabrication of graphene field effect transistors and their sensing applications. Graphene Field-Effect Transistors includes information on: Electronic properties of graphene, production of graphene oxide and reduced graphene oxide, and graphene functionalization Fundamentals and fabrication of graphene field effect transistors, and nanomaterial/graphene nanostructure-based field-effect transistors Graphene field-effect transistors integrated with microfluidic platforms and flexible graphene field-effect transistors Graphene field-effect transistors for diagnostics applications, and DNA biosensors and immunosensors based on graphene field-effect transistors Graphene field-effect transistors for targeting cancer molecules, brain activity recording, bacterial detection, and detection of smell and taste Providing both fundamentals of the technology and an in-depth overview of using graphene field effect transistors for fabricating bioelectronic devices that can be applied for point-of-care diagnostics, Graphene Field-Effect Transistors is an essential reference for materials scientists, engineering scientists, laboratory medics, and biotechnologists.
Author: Omar Azzaroni Publisher: John Wiley & Sons ISBN: 3527349901 Category : Technology & Engineering Languages : en Pages : 453
Book Description
Graphene Field-Effect Transistors In-depth resource on making and using graphene field effect transistors for point-of-care diagnostic devices Graphene Field-Effect Transistors focuses on the design, fabrication, characterization, and applications of graphene field effect transistors, summarizing the state-of-the-art in the field and putting forward new ideas regarding future research directions and potential applications. After a review of the unique electronic properties of graphene and the production of graphene and graphene oxide, the main part of the book is devoted to the fabrication of graphene field effect transistors and their sensing applications. Graphene Field-Effect Transistors includes information on: Electronic properties of graphene, production of graphene oxide and reduced graphene oxide, and graphene functionalization Fundamentals and fabrication of graphene field effect transistors, and nanomaterial/graphene nanostructure-based field-effect transistors Graphene field-effect transistors integrated with microfluidic platforms and flexible graphene field-effect transistors Graphene field-effect transistors for diagnostics applications, and DNA biosensors and immunosensors based on graphene field-effect transistors Graphene field-effect transistors for targeting cancer molecules, brain activity recording, bacterial detection, and detection of smell and taste Providing both fundamentals of the technology and an in-depth overview of using graphene field effect transistors for fabricating bioelectronic devices that can be applied for point-of-care diagnostics, Graphene Field-Effect Transistors is an essential reference for materials scientists, engineering scientists, laboratory medics, and biotechnologists.
Author: Yichen Lu Publisher: ISBN: Category : Languages : en Pages : 229
Book Description
The advancement of neuroscience research often requires recording of complex neural activities at high spatiotemporal resolution. Electrophysiology, being the backbone of neuroscience for decades, has the advantage of high temporal resolution, yet lacks the high spatial resolution of fluorescent imaging at single cell level. On the other hand, fluorescent imaging suffers from low temporal resolution due to the slow kinetics of the indicators. Recently, optogenetics revolutionized the capacity to control selective neural populations and provides researchers with unprecedented opportunities to investigate the causal relationships among different brain circuits. However, the traditional neural electrode arrays based on silicon and noble metals are opaque and hence not suitable to integrate electrophysiology and optical modalities. This dissertation presents a novel transparent microelectrode array based on graphene that demonstrates crosstalk-free integration of electrophysiology, calcium imaging, and optogenetics in in vivo experiments on mice models. Chapter 1 reviews the recent progress in the field of graphene-based neurotechnology. Graphene is widely used for microelectrode, field effect transistor, chemical sensing, and cell culture owing to its flexibility, transparency, high conductivity, low noise, and biocompatibility. Chapter 2 presents a novel transparent graphene microelectrode array designed for multimodal neural interfaces. The fabrication process was designed to avoid crack formation and organic residue, which is essential to eliminate light-induced artifacts. In vivo experiments were conducted to demonstrate a crosstalk-free integration of electrophysiology, optical imaging, and optogenetics for the first time. Chapter 3 demonstrates that electrochemical impedance of graphene is fundamentally limited by the quantum capacitance. And to overcome such limit, we created an alternative conduction path with electrochemically deposited platinum nanoparticles and reduced the impedance by 100-fold while maintaining high transparency. Chapter 4 presents a flexible implantable transparent microelectrode array that enables simultaneous electrical recordings from hippocampus during optical imaging of neural activity across large areas. Our neural probe has three advantages, flexibility, transparency, and shuttle-free implantation. We demonstrated seamless integration of simultaneous wide-field fluorescence imaging of the cortex with electrical recordings from the hippocampus. Chapter 5 is the conclusion of this dissertation. The outlook and roadmap of graphene-based neurotechnology for both neuroscience research and medical applications are discussed.
Author: Elisa López-Dolado Publisher: Springer Nature ISBN: 3030814009 Category : Medical Languages : en Pages : 327
Book Description
This book describes past and present advances in engineering materials for neural applications, with special emphasis on their usefulness for traumatic brain and spinal cord injuries. The book presents major physio-pathological features of traumatic injuries at the brain and spinal cord as examples of diseases hampering the central nervous tissue. By incorporating knowledge from the perspective of experts with diverse backgrounds, this book gives insight into the understanding of these multifaceted pathologies and the materials science approaches that aim to cure them. The interdisciplinary nature of this book makes it a perfect candidate for the interest of a broad audience, from clinicians working on neural diseases to scientists whose work focuses on the nervous tissue (neuroscientists) and/or materials science. Undergraduate and PhD students can also benefit from the knowledge and discussion included in this book.
Author: Anuj Kumar Publisher: CRC Press ISBN: 1000789470 Category : Technology & Engineering Languages : en Pages : 406
Book Description
Bioelectronics is emerging as a new area of research where electronics can selectively detect, record, and monitor physiological signals. This is a rapidly expanding area of medical research, that relies heavily on multidisciplinary technology development and cutting-edge research in chemical, biological, engineering, and physical science. This book provides extensive information on the (i) fundamental concepts of bioelectronics, (ii) materials for the developments of bioelectronics such as implantable electronics, self-powered devices, bioelectronic sensors, flexible bioelectronics, etc, and (iii) an overview of the trends and gathering of the latest bioelectronic progress. This book will broaden our knowledge about newer technologies and processes used in bioelectronics.
Author: Publisher: Elsevier ISBN: 0128051442 Category : Science Languages : en Pages : 2069
Book Description
Encyclopedia of Biomedical Engineering, Three Volume Set is a unique source for rapidly evolving updates on topics that are at the interface of the biological sciences and engineering. Biomaterials, biomedical devices and techniques play a significant role in improving the quality of health care in the developed world. The book covers an extensive range of topics related to biomedical engineering, including biomaterials, sensors, medical devices, imaging modalities and imaging processing. In addition, applications of biomedical engineering, advances in cardiology, drug delivery, gene therapy, orthopedics, ophthalmology, sensing and tissue engineering are explored. This important reference work serves many groups working at the interface of the biological sciences and engineering, including engineering students, biological science students, clinicians, and industrial researchers. Provides students with a concise description of the technologies at the interface of the biological sciences and engineering Covers all aspects of biomedical engineering, also incorporating perspectives from experts working within the domains of biomedicine, medical engineering, biology, chemistry, physics, electrical engineering, and more Contains reputable, multidisciplinary content from domain experts Presents a ‘one-stop’ resource for access to information written by world-leading scholars in the field
Author: Shiyu Wang Publisher: Springer Nature ISBN: 9811612129 Category : Technology & Engineering Languages : en Pages : 123
Book Description
In this monograph, the graphene-based field-effect transistor (FET) biosensors are shown to be an emerging sensing platform. Divided into two parts the first set of chapters are devoted to basic knowledge of graphene, graphene FET and its biosensing. In the second part of this book the applications of graphene FET biosensors combined with various biotechnologies are presented. As well as discussing the existing technologies the authors also introduce their own ideas and concepts. Finally the remaining problems in graphene FET biosensors are discussed, along with proposed solutions and prospects for future applications. This monograph allows readers to grasp the basic knowledge and future direction of graphene-based FET biosensors.
Author: Akio Yasuda Publisher: Materials Research Forum LLC ISBN: 1644900378 Category : Technology & Engineering Languages : en Pages : 56
Book Description
Novel bio-electronic devices have a great potential for gathering biological information such as vital signs, cell behavior, protein and DNA molecule concentrations. The book presents concrete examples and shows that there are lots of sensing targets still remaining to be handled. Organic materials offer high sensitivity, flexibility and biocompatibility, and can be prepared by novel fabrication methods such as printing and coating at low cost. Part 1: OFET-based sensors. Part 2: Graphene-based materials and sensor device applications. Part 3: Applications of bio-sensing technologies, inkjet printing, tests for stroke monitoring, etc.
Author: E. L. Wolf Publisher: Springer Science & Business Media ISBN: 3319039466 Category : Technology & Engineering Languages : en Pages : 87
Book Description
Graphene is presented and analyzed as a replacement for silicon. The Primary focus is on solar cell and CMOS device technologies, with attention to the fabrication methods, including extensions needed, in each case. Specialized applications for graphene within the existing silicon technology are discussed and found to be promising.
Author: Dong-Wook Park
Author: Dong-Wook Park
Author: Omar Azzaroni
Author: Omar Azzaroni
Author: Yichen Lu
Author: Elisa López-Dolado
Author: Anuj Kumar
Author: 
Author: Shiyu Wang
Author: Akio Yasuda
Author: E. L. Wolf