Translational Approaches to Autism Spectrum Disorder PDF Download

Author: Maria de los Angeles Robinson-Agramonte
Publisher: Springer
ISBN: 3319163213
Category : Medical
Languages : en
Pages : 222

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Book Description
This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Among the topic addressed are neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.

Author: Maria de los Angeles Robinson-Agramonte
Publisher:
ISBN: 9783319163222
Category :
Languages : en
Pages :

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Book Description
This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Topics addressed in this book include neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.

Author: Paolo Sassone-Corsi
Publisher: Springer
ISBN: 3319270699
Category : Medical
Languages : en
Pages : 141

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Book Description
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Author: Michael J. Schmeisser
Publisher: Springer
ISBN: 3319524984
Category : Medical
Languages : en
Pages : 216

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Book Description
Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.

Author: Detlev Boison
Publisher: Oxford University Press
ISBN: 0199322295
Category : Medical
Languages : en
Pages : 657

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Book Description
Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Author: Elena Choleris
Publisher: Cambridge University Press
ISBN: 0521190355
Category : Medical
Languages : en
Pages : 409

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Book Description
A comparative overview of the effects of neuropeptides on behavior, examining parallel findings in both humans and non-human animals.

Author: Alessandro Grecucci
Publisher: Frontiers Media SA
ISBN: 2889453162
Category :
Languages : en
Pages : 143

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Book Description
In the last twenty years, many attempts have been made to provide neurobiological models of autism. Functional, structural and connectivity analyses have highlighted reduced responses in key social areas, such as amygdala, medial prefrontal cortex, cingulate cortex, and superior temporal sulcus. However, these studies present discrepant results and some of them have been questioned for methodological limitations. The aim of this research topic is to present advanced neuroimaging methods able to capture the complexity of the neural deficits displayed in autism. This special issue presents new studies using structural and functional MRI, as well as magnetoencephalography, and novel protocols to analyze data (Analysis of Cluster Variability, Noise Reduction Strategies, Source-based Morphometry, Functional Connectivity Density, Restriction Spectrum Imaging and the others). We believe it is time to integrate data provided by different techniques and methodologies in order to have a better understanding of autism.

Author: Eric Hollander, M.D.
Publisher: American Psychiatric Pub
ISBN: 1615373047
Category : Medical
Languages : en
Pages : 744

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Book Description
More than 40 years after the official recognition of infantile autism in DSM-III, advances continue to be made in our understanding of the possible causes, assessment and evaluation, and treatment of autism spectrum disorder (ASD). With contributions by dozens of experts in the field, this second edition of the Textbook of Autism Spectrum Disorders has been updated to reflect the latest research in ASD. Unrivaled in its thoroughness, this volume discusses issues of assessment and evaluation; examines the etiology of ASD and its recognized associations with other medical conditions; analyzes standard and experimental treatments; and delves into social policy issues pertinent to individuals with ASD and those who treat them. With summary points in each chapter and copious lists of recommended readings, this is an indispensable resource for psychiatrists, psychologists, neurologists, social workers, speech therapists, educators, and all others in the continuum of care.

Author: Laurie K McLay
Publisher: Springer Nature
ISBN: 3030991342
Category : Psychology
Languages : en
Pages : 301

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Book Description
This handbook provides an overview of the nature, prevalence, and causes of sleep problems in children with autism spectrum disorder (ASD) and examines the process of using functional behavior assessment (FBA) to treat sleep disorders. It describes several evidence-based treatments and explores how these align with the outcomes of the FBA process, including case illustrations of the assessment and treatment process. The handbook discusses the application of FBA in family contexts, including: The effects on children and families of successful interventions with sleep. How to conduct FBA with clinically complex families. Including the child in the intervention. The evidence of efficacy of other treatment approaches. The handbook addresses sleep problems that are highly prevalent among children and young people with ASD, including sleep onset delay, frequent and prolonged night waking, and unwanted co-sleeping. It explores the profound secondary effects that sleep problems may have on children’s daytime functioning as well as child and parent health and wellbeing. The handbook discusses the causes of sleep problems in individuals with ASD, which may be multifaceted and complex and include physiological, environmental, cognitive etiologies yet almost always have a behavioral or learned component. It examines how FBA can be used to characterize challenging behaviors and identify the antecedents (e.g., environmental context) and consequences that affect such behaviors. The volume details the process of using FBA to assess and treat sleep problems in children with ASD. Clinical Handbook of Behavioural Sleep Treatment in Autism is a must-have resource for clinicians, therapists, and other practitioners as well as researchers and graduate students in clinical child and school psychology, behavioral therapy, social work, public health, developmental psychology, pediatrics, family studies, and child and adolescent psychiatry.

Author: Stephen Deutsch
Publisher: BoD – Books on Demand
ISBN: 9533074957
Category : Science
Languages : en
Pages : 214

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Book Description
Estimated prevalence rates of autism spectrum disorders (ASDs) have increased at an alarming rate over the past decade; current estimates stand as high as 1 in 110 persons in the population with a higher ratio of affected males to females. In addition to their emotional impact on the affected persons and their family members (in fact, the latter are often unrecognized unaffected “patients” themselves), the economic and social impacts of ASDs on society are staggering. Persons with ASDs will need interdisciplinary approaches to complex treatment and life planning, including, but not limited to, special education, speech and language therapy, vocational skills training and rehabilitation, social skills training and cognitive remediation, in addition to pharmacotherapy. The current book highlights some of the recent research on nosology, etiology, and pathophysiology. Additionally, the book touches on the implications of new research for treatment and genetic counseling. Importantly, because the field is advancing rapidly, no book can be considered the final word or finished product; thus, the availability of open access rapid publication is a mechanism that will help to assure that readers remain current and up-to-date.