Author: I.S. Krull Publisher: Elsevier ISBN: 0080858546 Category : Science Languages : en Pages : 319
Book Description
The aim of this volume is to describe the most recent advances in areas of analytical chemistry that relate to the trace determination of metals and inorganics, as well as their distribution and forms (species) present, sample dependent. Analytical approaches are described that encompass a number of separation methods, such as gas and high performance liquid chromatography, interfaced with selective and sensitive detection methods that become unique for metal species/forms present in various samples. Hyphenated techniques are emphasized, such as interfacing HPLC with plasma induced emission spectroscopy, electrochemistry, post-column reaction chemistry, etc. Each chapter describes the latest instrumental and methodology advances that utilize some form of chromatography together with element-specific detection or mass spectrometry to provide absolute identification of the specific species of a metal present in various samples. The book will be of value to those concerned with the determination of trace levels of individual metal species present or suspected present in any given sample and to those involved in trace metal toxicology, metabolism of metal-containing drugs or chemicals, environmental exposures to metals and chemical speciation of real world samples. Government regulatory laboratories striving to detect and determine absolute levels of a metal species in any regulated sample will be interested in this volume, as will academic institutes involved in environmental toxicology, environmental chemistry, metal-DNA/protein interactions and researchers working with metal species.
Author: Yuanyuan Yang Publisher: ISBN: Category : Chemistry, Analytic Languages : en Pages : 139
Book Description
Detection of trace metals has great importance in environmental and biological applications. While traditional electrochemical techniques have played critical roles in this field, their usefulness is limited by temporal resolution, Hg toxicity and stability concerns. Recently, we developed a method using fast-scan cyclic voltammetry (FSCV) at carbon-fiber microelectrodes (CFMs) to achieve rapid measurement of metal ions with high sensitivity, selectivity, and stability. Through optimizations this method showed strengths in real-time trace metal analysis. Analytical selectivity was improved via covalent functionalization on CFMs. We employed diazonium electrochemical reduction followed by click chemistry to create robust covalent attachments. We showcased its application through grafting Cu(II) ionophores onto CFMs. The selectivity was further reinforced via inhibition of other species' adsorption at surface oxygen groups. This stepwise functionalization approach served as a universal platform for elevating CFMs' selectivity, while retaining sensitivity, response, stability, and lifetime. In parallel work, pyrolyzed photoresist film (PPF) microelectrode arrays (MEAs) were fabricated to extend the borderlines of FSCV towards simultaneous multi-analyte analysis. The PPF MEAs maintained CFM's carbon-fiber structures but provided more sensing channels. We employed a two-step pyrolysis process and a dual oxygen plasma treatment to improve fabrication repeatability, surface reactivity, and spatial geometry. Our technique has evident potential to achieve real-time simultaneous detection of various electroactive molecules and be employed for numerous applications in complex biological and environmental systems.
Author: Mario Alfonso Murillo-Tovar Publisher: BoD – Books on Demand ISBN: 1838803319 Category : Languages : en Pages : 285
Book Description
The occurrence of heavy metals in the environment, even in traces, represents a severe risk for the ecosystems and can be dangerous to human health. However, a better understanding of the main aspects involved is still needed to reduce its negative impact on the environment and health. This book covers the recent methods used for the evaluation of heavy metal pollution and the identification of its sources, descriptions of some of the processes involved in its mobility and transport, attempts to address health and environmental effects of heavy metals pollution, and presents alternative technologies for its removal and remediation from environmental samples. Therefore, this book is recommended for experts in the comprehensive management of metal contamination in different environmental compartments.
Author: Jerome O. Nriagu Publisher: MIT Press ISBN: 0262552485 Category : Medical Languages : en Pages : 501
Book Description
Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang
Author: National Research Council Publisher: National Academies Press ISBN: 0309039940 Category : Medical Languages : en Pages : 765
Book Description
Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.
Author: I.S. Krull
Author: Yuanyuan Yang
Author: Mario Alfonso Murillo-Tovar
Author: Christopher J. Thompson
Author: National Institute of Law Enforcement and Criminal Justice
Author: Anne Tamnai Maghasi
Author: National Institute of Law Enforcement and Criminal Justice
Author: Stevan Bauer Saban
Author: Jerome O. Nriagu
Author: National Research Council