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Author: P R Working Publisher: CRC Press ISBN: 9780891165835 Category : Medical Languages : en Pages : 365
Book Description
This reference work focuses on the practice of reproductive toxicology, providing a foundation in basic male and female reproductive physiology for the application and improvement of existing model systems.
Author: National Research Council Publisher: National Academies Press ISBN: 0309036879 Category : Nature Languages : en Pages : 476
Book Description
The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.
Author: P R Working Publisher: CRC Press ISBN: 9780891165835 Category : Medical Languages : en Pages : 365
Book Description
This reference work focuses on the practice of reproductive toxicology, providing a foundation in basic male and female reproductive physiology for the application and improvement of existing model systems.
Author: PK Working (Ed) Publisher: ISBN: Category : Languages : en Pages :
Book Description
Testicular Structure and Physiology, A Toxicologist's View; Regulation of Ovarian Function; Biology of the Gamete, Maturation, Transport, and Fertilization; Mechanisms of Action of Reproductive Toxicants; Design and Use of Multigeneration Breeding Studies for Identification of Reproductive Toxicants; Significance of Cellular End Points in Assessment of Male Reproductive Toxicity; End Points for Assessing Reproductive Toxicology in the Female; Through the Looking Glass, Fact and Artifact in Histopathology; Quantitative Assessment of Spermatogenesis; Association of Sperm, Vaginal Cytology, and Reproductive Organ Weight Data with Fertility of Swiss (CD-1) Mice; Impaired Gamete Function, Implications for Reproductive Toxicology; Germ Cell Genotoxicity, Methods for Assessment of DNA Damage and Mutagenesis; Importance of Assessing Multiple End Points in Reproductive Toxicology Studies; Testis En Plastique, Use and Abuse of In Vitro Systems; Toxic and Mutagenic Effects on Spermatogenesis with Special Reference to Meiotic Micronucleus Induction In Vitro; Interspecies Comparison and Quantitative Extrapolation of Toxicity to the Human Male Reproductive System; Detecting Toxicity to the Human Reproductive System Using Epidemiological Methods; Risk Analysis in Reproductive Toxicology.
Author: Robert W. Kapp Publisher: CRC Press ISBN: 1420073443 Category : Medical Languages : en Pages : 422
Book Description
Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology's contributors are experienced regulatory agency and Clinical Research Organization representatives w
Author: J Witorsch Raphael Publisher: CRC Press ISBN: 9780781702256 Category : Medical Languages : en Pages : 360
Book Description
Presents not only the major principles and current issues in the field but also provides a physiologic basis for the actions and reactions to reproductive toxic agents. The volume is divided into three sections. The first focuses on the current concepts of normal mammalian reproductive function from the systems to subcellular level. The second explains how toxic substances disrupt the normal functioning of elements of the mammalian reproductive system. The third section discusses other issues of long-standing or recent interest to the field, such as clinical aspects, epidemiology, and the toxic effects of low-energy electromagnetic fields and tobacco, alcohol, and other substances of abuse. Annotation copyright by Book News, Inc., Portland, OR
Author: National Research Council (U.S.). Subcommittee on Reproductive and Neurodevelopmental Toxicology Publisher: Routledge ISBN: Category : Medical Languages : en Pages : 424
Author: Ramesh C Gupta Publisher: Academic Press ISBN: 0123820332 Category : Medical Languages : en Pages : 1243
Book Description
Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. Provides a complete, integrated source of information on the key risk stages during reproduction and development Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis
Author: James C. Lamb Publisher: Elsevier ISBN: 1483272079 Category : Medical Languages : en Pages : 283
Book Description
Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to the male sex. Some papers discuss testicular organization, reproductive toxicity testing systems, and germ-cell genetic toxicology. The use of in vitro systems by investigators to dissect the male reproductive toxicants can lead to a more scientific approach toward hazard assessment and the development of safer drugs and chemicals. Other papers explain the fundamental reproductive biology of the testis, the neuroendocrine system, the epididymis and accessory sex organs, and spermatozoal evaluation. Toxicological aspects cover the toxicological evaluation of the complete reproductive system, testicular morphology, sperm assessment, and germ-cell mutagenesis. One paper describes alternative methods in toxicology—by using new in vitro systems that should reduce or eliminate the need for tests conducted on animals. In vitro methodology embraces other systems such as from subcellular fractions to isolated intact organs. In relation to target-organ toxicity, the researcher can focus using primary cell cultures. This collection will prove helpful to toxicologists, graduate students and researchers in biology, particularly in male reproductive toxicology and fertility testing.
Author: P R Working
Author: National Research Council
Author: P R Working
Author: PK Working (Ed)
Author: Robert W. Kapp
Author: Robert E. Chapin
Author: J Witorsch Raphael
Author: National Research Council (U.S.). Subcommittee on Reproductive and Neurodevelopmental Toxicology
Author: Jerrold J. Heindel
Author: Ramesh C Gupta
Author: James C. Lamb