Toxicological Studies on Beryllium Oxides and Beryllium-containing Exhaust Products PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Toxicological Studies on Beryllium Oxides and Beryllium-containing Exhaust Products PDF full book. Access full book title Toxicological Studies on Beryllium Oxides and Beryllium-containing Exhaust Products by Howard C. Spencer. Download full books in PDF and EPUB format.
Author: Howard C. Spencer Publisher: ISBN: Category : Languages : en Pages : 268
Book Description
Results of long-term studies on rats and rabbits, injected intratracheally with well-characterized key samples of beryllium oxide prepared by calcining beryllium hydroxide for 10 hours at 500, 1100 and 1600 C, respectively, show clearly that there is a definite gradation in biological response depending upon the oxide administered. Thus, the oxide calcined at 500 C was highly active as judged by histopathological examination of the lungs, incidence of tumors, and translocation of beryllium from the lungs to other tissues. In contrast, the oxide calcined at 1600 C showed only minimal effects. Dose-response studies were carried out, using carefully prepared subsamples of 'respirable particle size' (1 to 5 microns) of the three key oxides; results showed a definite gradation in response which diminishes with decreasing dosages of the administered oxide. Investigations on motor exhaust products show that some samples have chemical, physical, and toxicological properties similar to the beryllium oxide calcined at 1600 C. On the other hand, other samples are heterogeneous, contain considerable quantities of water-soluble beryllium, and vary in toxicity. The mechanism of toxic action of beryllium oxide was investigated through study of chemical and physical properties, solubility and adsorption studies, serum electrophoretic analyses, and immunological experiments. Suggestions are made for further studies. (Author).
Author: Howard C. Spencer Publisher: ISBN: Category : Languages : en Pages : 268
Book Description
Results of long-term studies on rats and rabbits, injected intratracheally with well-characterized key samples of beryllium oxide prepared by calcining beryllium hydroxide for 10 hours at 500, 1100 and 1600 C, respectively, show clearly that there is a definite gradation in biological response depending upon the oxide administered. Thus, the oxide calcined at 500 C was highly active as judged by histopathological examination of the lungs, incidence of tumors, and translocation of beryllium from the lungs to other tissues. In contrast, the oxide calcined at 1600 C showed only minimal effects. Dose-response studies were carried out, using carefully prepared subsamples of 'respirable particle size' (1 to 5 microns) of the three key oxides; results showed a definite gradation in response which diminishes with decreasing dosages of the administered oxide. Investigations on motor exhaust products show that some samples have chemical, physical, and toxicological properties similar to the beryllium oxide calcined at 1600 C. On the other hand, other samples are heterogeneous, contain considerable quantities of water-soluble beryllium, and vary in toxicity. The mechanism of toxic action of beryllium oxide was investigated through study of chemical and physical properties, solubility and adsorption studies, serum electrophoretic analyses, and immunological experiments. Suggestions are made for further studies. (Author).
Author: National Research Council Publisher: National Academies Press ISBN: 0309125324 Category : Medical Languages : en Pages : 186
Book Description
Beryllium is a lightweight metal that is used for its exceptional strength and high heat-absorbing capability. Beryllium and its alloys can be found in many important technologies in the defense and aeronautics industries, such as nuclear devices, satellite systems, radar systems, and aircraft bushings and bearings. Pulmonary disease associated with exposure to beryllium has been recognized and studied since the early 1940s, and an occupational guideline for limiting exposure to beryllium has been in place since 1949. Over the last few decades, much has been learned about chronic beryllium disease and factors that contribute to its occurrence in exposed people. Despite reduced workplace exposure, chronic beryllium disease continues to occur. Those developments have led to debates about the adequacy of the long-standing occupational exposure limit for protecting worker health. This book, requested by the U.S. Air Force to help to determine the steps necessary to protect its workforce from the effects of beryllium used in military aerospace applications, reviews the scientific literature on beryllium and outlines an exposure and disease management program for its protecting workers.
Author: Howard C. Spencer
Author: Howard C. Spencer
Author: 
Author: Defense Documentation Center (U.S.)
Author: National Research Council
Author: 
Author: 
Author: 
Author: 
Author: 
Author: