Author: Publisher:
ISBN:
Category : Methyl chloride
Languages : en
Pages : 264
Book Description
Toxicological Profile for Chloromethane
Author: Toxicological Profile for 1,2-dibromoethane
Author: Taking an Exposure History
Author: Arthur L. FrankPublisher:
ISBN:
Category : Environmental monitoring
Languages : en
Pages : 60
Book Description
Toxicological Profile for Chloroethane
Author: Toxicological Profile for Chloroethane
Author: Toxicological Profile for 1,1,2,2-tetrachloroethane
Author: Publisher:
ISBN:
Category : 1,1,2,2-Tetrachloroethane
Languages : en
Pages : 190
Book Description
Toxicological Profile for 1,1,2,2-tetrachloroethane
Author: Mutagenic Impurities
Author: Andrew TeasdalePublisher: John Wiley & Sons
ISBN: 1119551218
Category : Medical
Languages : en
Pages : 548
Book Description
Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.
Toxicological Profile for 1,1,2,2-tetrachloroethane
Author: Publisher:
ISBN:
Category : 1,1,2,2-Tetrachloroethane
Languages : en
Pages : 190
Book Description
Toxicological Profile for Polybrominated Biphenyls (PBBS)
Author: Publisher:
ISBN:
Category : Polybrominated biphenyls
Languages : en
Pages : 286
Book Description