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Author: Manoj C. Desai Publisher: Royal Society of Chemistry ISBN: 1849737819 Category : Science Languages : en Pages : 551
Book Description
The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is tolerant of manageable side effects and adaptable to inconvenient dosing. Aimed at medicinal chemists and emerging drug discovery scientists, the book is organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. This book focuses on capturing tactical aspects of problem solving in antiviral drug design, an approach that holds special appeal for those engaged in antiviral drug development, but also appeals to the broader medicinal chemistry community based on its focus on tactical aspects of drug design.
Author: Manoj C. Desai Publisher: Royal Society of Chemistry ISBN: 1849737819 Category : Science Languages : en Pages : 551
Book Description
The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is tolerant of manageable side effects and adaptable to inconvenient dosing. Aimed at medicinal chemists and emerging drug discovery scientists, the book is organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. This book focuses on capturing tactical aspects of problem solving in antiviral drug design, an approach that holds special appeal for those engaged in antiviral drug development, but also appeals to the broader medicinal chemistry community based on its focus on tactical aspects of drug design.
Author: M. Necmettin Pamir Publisher: Springer Science & Business Media ISBN: 3211996516 Category : Medical Languages : en Pages : 253
Book Description
Intraoperative imaging technologies have taken an ever-increasing role in the daily practice of neurosurgeons and the increasing attention and interest necessitated international interaction and collaboration. The Intraoperative Imaging Society was formed in 2007. This book brings together highlights from the second meeting of the Intraoperative Imaging Society, which took place in Istanbul-Turkey from June 14 to 17, 2009. Included within the contents of the book is an overview of the emergence and development of the intraoperative imaging technology as well as a glimpse on where the technology is heading. This is followed by in detail coverage of intraoperative MRI technology and sections on intraoperative CT and ultrasonography. There are also sections on multimodality integration, intraoperative robotics and other intraoperative technologies. We believe that this book will provide an up-to date and comprehensive general overview of the current intraoperative imaging technology as well as detailed discussions on individual techniques and clinical results.
Author: Simon Jungblut Publisher: Springer Nature ISBN: 3030203891 Category : Animal culture Languages : en Pages : 378
Book Description
This open access book summarizes peer-reviewed articles and the abstracts of oral and poster presentations given during the YOUMARES 9 conference which took place in Oldenburg, Germany, in September 2018. The aims of this book are to summarize state-of-the-art knowledge in marine sciences and to inspire scientists of all career stages in the development of further research. These conferences are organized by and for young marine researchers. Qualified early-career researchers, who moderated topical sessions during the conference, contributed literature reviews on specific topics within their research field. .
Author: Sean Cubitt Publisher: MIT Press ISBN: 0262318334 Category : Art Languages : en Pages : 395
Book Description
Leading historians of the media arts define a new materialist media art history, discussing temporality, geography, ephemerality, and the future. In Relive, leading historians of the media arts grapple with this dilemma: how can we speak of “new media” and at the same time write the histories of these arts? These scholars and practitioners redefine the nature of the field, focusing on the materials of history—the materials through which the past is mediated. Drawing on the tools of media archaeology and the history and philosophy of media, they propose a new materialist media art history. The contributors consider the idea of history and the artwork's moment in time; the intersection of geography and history in regional practice, illustrated by examples from eastern Europe, Australia, and New Zealand; the contradictory scales of evolution, life cycles, and bodily rhythms in bio art; and the history of the future—how the future has been imagined, planned for, and established as a vector throughout the history of new media arts. These essays, written from widely diverse critical perspectives, capture a dynamic field at a moment of productive ferment. Contributors Susan Ballard, Brogan Bunt, Andrés Burbano, Jon Cates, John Conomos, Martin Constable, Sean Cubitt, Francesca Franco, Darko Fritz, Zhang Ga, Monika Gorska-Olesinska, Ross Harley, Jens Hauser, Stephen Jones, Douglas Kahn, Ryszard W. Kluszczynski, Caroline Seck Langill, Leon Marvell, Rudy Rucker, Edward A. Shanken, Stelarc, Adele Tan, Paul Thomas, Darren Tofts, Joanna Walewska
Author: Justin Martell Publisher: Jawbone Press ISBN: 9781908279873 Category : Music Languages : en Pages : 0
Book Description
As Bing Crosby once put it, Tiny Tim represents 'one of the most phenomenal success stories in show business'. In 1968, after years of playing dive bars and lesbian cabarets on the Greenwich Village scene, rubbing shoulders with the likes of Bob Dylan and Lenny Bruce, the forty-something falsetto-voiced, ukulele-playing Tiny Tim landed a recording contract with Sinatra's Reprise label and an appearance on NBC's Laugh-In. The resulting album, God Bless Tiny Tim, and its single, 'Tip-toe Thru' The Tulips With Me', catapulted him to the highest levels of fame. Soon, Tiny was playing to huge audiences in the USA and Europe, while his marriage to the seventeen-year-old 'Miss' Vicki was broadcast on The Tonight Show in front of an audience of fifty million. Before long, however, his star began to fade. Miss Vicki left him, his earnings evaporated, and the mainstream turned its back on him. He would spend the rest of his life trying to revive his career, with many of those attempts taking a turn toward the absurd. But while he is often characterized as an oddball curio, Tiny Tim was a master interpreter and student of early American popular song, and his story is one of Shakespearean tragedy framed around a bizarre yet loveable public persona. Here, drawing on dozens of new interviews, never-before-seen diaries, and years of original research, author Justin Martell brings that story to life with the first serious biography of one of the most fascinating yet misunderstood figures in popular music.
Author: Panayiotis Varelas Publisher: Springer Science & Business Media ISBN: 1592598412 Category : Medical Languages : en Pages : 391
Book Description
A panel of international ICU and epilepsy physicians and researchers detail the epileptic phenomena that occur in the complex environment of the ICU. Focusing on the central nervous system, the authors systematically examine the most up-to-date evidenced-based data regarding ICU seizures, including their most frequent causes, their pathophysiology, their clinical presentation, and the diagnostic evaluation needed to confirm their presence. They also discuss the challenges and specifics of the management of ICU seizures, reviewing the new antiepileptics and their interaction with other ICU medications, drugs with epileptogenic properties used in the ICU, and the role of the new enterally available antiepileptics in treating seizures. Numerous tables summarize drug interactions, neuroimages reveal common ICU seizure etiologies, and multiple electroencephalographic recordings demonstrate clinical or subclinical seizures in ICU patients.
Author: Manoj C. Desai
Author: Manoj C. Desai
Author: M. Necmettin Pamir
Author: Simon Jungblut
Author: Adelola Adeloye
Author: Sean Cubitt
Author: Edwin Walter Kemmerer
Author: Clinton Hartley Grattan
Author: American Economic Association
Author: Justin Martell
Author: Panayiotis Varelas