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Author: Michael Aschner Publisher: CRC Press ISBN: 9780849317941 Category : Medical Languages : en Pages : 480
Book Description
Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases. The book is structured to examine the interactions between glial cells and neurons during development, adulthood, and senescence, followed by specific examples of directly mediated glial neurotoxicity. The book also covers miscellaneous topics in glial physiology/biochemistry such as signaling and edema. The book includes coverage of advances in our knowledge and understanding of glial physiology and biochemistry. Discover what's new in the Second Edition: Neuronal-glia metabolic interactions Neuronal-glia interactions (glutamate homeostasis) Zinc transporters in glia Energy deprivation/mitochondrial dysfunction - unique astrocyte susceptibilities Astrocytes and MPTP neurotoxicity Astroglia and food toxins Current understanding of the importance of glia has caused a boom in published information. Yet while many of the published textbooks are multifaceted and multidisciplinary, none includes the role of glia in neurotoxicity. Written by leaders in the field of glial research, this text fills this missing gap in the literature. Broader in scope than the first edition, including contributions from internationally known researchers, this is still the only book dedicated to exploring the role of glial cells in mediating neurotoxicology. Features Summarizes the latest research in glial cell function gleaned from new techniques in imaging and molecular biology Contains tables and figures that give you quick and easy access to precise data Includes a contemporary summary of literature that puts information useful for grant submissions at your fingertips Features new chapters covering metabolic interactions, glutamate homeostasis, transporters, energy deprivation/mitochondrial dysfunction, astrocytes, and food toxins Explores the role of glial cells in mediating neurotoxicity and incorporates information on specific effects of many compounds
Author: Michael Aschner Publisher: CRC Press ISBN: 9780849317941 Category : Medical Languages : en Pages : 480
Book Description
Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases. The book is structured to examine the interactions between glial cells and neurons during development, adulthood, and senescence, followed by specific examples of directly mediated glial neurotoxicity. The book also covers miscellaneous topics in glial physiology/biochemistry such as signaling and edema. The book includes coverage of advances in our knowledge and understanding of glial physiology and biochemistry. Discover what's new in the Second Edition: Neuronal-glia metabolic interactions Neuronal-glia interactions (glutamate homeostasis) Zinc transporters in glia Energy deprivation/mitochondrial dysfunction - unique astrocyte susceptibilities Astrocytes and MPTP neurotoxicity Astroglia and food toxins Current understanding of the importance of glia has caused a boom in published information. Yet while many of the published textbooks are multifaceted and multidisciplinary, none includes the role of glia in neurotoxicity. Written by leaders in the field of glial research, this text fills this missing gap in the literature. Broader in scope than the first edition, including contributions from internationally known researchers, this is still the only book dedicated to exploring the role of glial cells in mediating neurotoxicology. Features Summarizes the latest research in glial cell function gleaned from new techniques in imaging and molecular biology Contains tables and figures that give you quick and easy access to precise data Includes a contemporary summary of literature that puts information useful for grant submissions at your fingertips Features new chapters covering metabolic interactions, glutamate homeostasis, transporters, energy deprivation/mitochondrial dysfunction, astrocytes, and food toxins Explores the role of glial cells in mediating neurotoxicity and incorporates information on specific effects of many compounds
Author: Michael Aschner Publisher: CRC Press ISBN: 1420039741 Category : Medical Languages : en Pages : 477
Book Description
Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases.
Author: Jean Harry G Publisher: CRC Press ISBN: 9781560327202 Category : Medical Languages : en Pages : 404
Book Description
This second edition of Neurotoxicology is valuable for scientists in government and industry who are responsible for public health and for the safe and efficient use of chemicals. This integrated approach to neurotoxicology will aid in the understanding of the sites and mechanisms of neurotoxicity, stimulate the formulation of testable hypotheses about how chemicals affect the nervous system, and help improve the risk assessment process. This edition focuses primarily on the neurobiological basis underlying neurotoxic sites and modes of action. The contents include: *molecular biological and in vitro approaches *potential cellular and molecular sites involving neuron-glia interactions *axonal transport *ion channels *metabolic influences on neurotoxicity *role of free radical formation in neurotoxicity *interaction between chemicals and trophic factors *endocrine disruptors *apoptosis in neurotoxicity *in vivo brain imaging *advances in measuring cognitive function *advances in developing quantitative models for neurotoxicology/risk assessment
Author: National Research Council Publisher: National Academies Press ISBN: 0309045312 Category : Science Languages : en Pages : 167
Book Description
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Author: Beth Stevens Publisher: ISBN: 9781621824640 Category : Neuroglia Languages : en Pages : 0
Book Description
"Glial cells are non-neuronal cells that support and protect neurons in the nervous systems. Once thought to be passive bystanders, they are increasingly appreciated for their active roles in nervous system development, function, and disease. This second edition will explore the major progress made in the field over the past few years"--
Author: Daniel Laskowitz Publisher: CRC Press ISBN: 1498766579 Category : Medical Languages : en Pages : 388
Book Description
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author: Firas H. Kobeissy Publisher: CRC Press ISBN: 1466565993 Category : Medical Languages : en Pages : 718
Book Description
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Author: William M. Reichert Publisher: CRC Press ISBN: 1420009303 Category : Medical Languages : en Pages : 300
Book Description
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
Author: Neurosciences Institute (New York, N.Y.) Publisher: Wiley-Interscience ISBN: Category : Medical Languages : en Pages : 808
Book Description
This book consists of five sections. The first section details methods for analyzing both presynaptic and postsynaptic function and emphasizes the molecular aspects of synapses. It describes ongoing studies of neurotransmitter release, voltage- sensitive ion channels, and electronic transmission at gap junctions. The second section focuses on the growing menagerie of neurotransmitters: their catagorization into chemical families, their relation to ion channels, their modulation by second messenger systems and their role in pharmacologic action. The third section considers the important relationship of transmitter diversity and synaptic types to the behavior of actual cellular networks. All of the studies described in these sections point to the necessity of considering interactions between anatomy, chemistry, physiology and pharmacology if synaptic function is to be understood at any one of these levels of analysis.
Author: Michael Aschner
Author: Michael Aschner
Author: Michael Aschner
Author: Peter Philip Thornton
Author: Jean Harry G
Author: National Research Council
Author: Beth Stevens
Author: Daniel Laskowitz
Author: Firas H. Kobeissy
Author: William M. Reichert
Author: Neurosciences Institute (New York, N.Y.)