Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The MIF Handbook PDF full book. Access full book title The MIF Handbook by Richard Bucala. Download full books in PDF and EPUB format.
Author: Richard Bucala Publisher: World Scientific ISBN: 9814335355 Category : Medical Languages : en Pages : 399
Book Description
The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
Author: Richard Bucala Publisher: World Scientific ISBN: 9814335355 Category : Medical Languages : en Pages : 399
Book Description
The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
Author: Richard Bucala Publisher: World Scientific ISBN: 9814475459 Category : Science Languages : en Pages : 330
Book Description
In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development.
Author: Auerbach Publisher: CRC Press ISBN: 1482287811 Category : Business & Economics Languages : en Pages : 632
Book Description
The Enterprise Operations Management Handbook provides the expert advice and guidance of hundreds of leading computing practitioners and consultants. Covering all major areas of enterprise operations management, this edition provides essential information for managing a modern, evolving data center. Topics include business issues, technology issues
Author: Steve Blanding Publisher: CRC Press ISBN: 1420052160 Category : Business & Economics Languages : en Pages : 632
Book Description
The Enterprise Operations Management Handbook provides the expert advice and guidance of hundreds of leading computing practitioners and consultants. Covering all major areas of enterprise operations management, this edition provides essential information for managing a modern, evolving data center. Topics include business issues, technology issues, and operational issues. This current, practical reference also reviews such critical areas as strategic planning, data center management, data center controls, systems planning, network technology, contingency planning, human resource planning, desktop computing, and future directions. The Enterprise Operations Management Handbook serves as an invaluable tool for designing, building, and maintaining a high-performance, service-oriented data center.
Author: Steven F. Blanding Publisher: CRC Press ISBN: 100015274X Category : Computers Languages : en Pages : 482
Book Description
The Enterprise Operations Management Handbook provides the expert advice and guidance of hundreds of leading computing practitioners and consultants. Covering all major areas of enterprise operations management, this edition provides essential information for managing a modern, evolving data center. Topics include business issues, technology issues, and operational issues. This current, practical reference also reviews such critical areas as strategic planning, data center management, data center controls, systems planning, network technology, contingency planning, human resource planning, desktop computing, and future directions. The Enterprise Operations Management Handbook serves as an invaluable tool for designing, building, and maintaining a high-performance, service-oriented data center.
Author: Krishna B. Misra Publisher: Springer Science & Business Media ISBN: 1848001312 Category : Technology & Engineering Languages : en Pages : 1331
Book Description
Dependability and cost effectiveness are primarily seen as instruments for conducting international trade in the free market environment. These factors cannot be considered in isolation of each other. This handbook considers all aspects of performability engineering. The book provides a holistic view of the entire life cycle of activities of the product, along with the associated cost of environmental preservation at each stage, while maximizing the performance.
Author: Tihamer Tóth Publisher: ISBN: 1108831710 Category : Law Languages : en Pages : 769
Book Description
A unique comparison of the theory and practice of corporate and individual sanctions applied in competition law across five continents.
Author: Frank H. Knight Publisher: Cosimo, Inc. ISBN: 1602060053 Category : Business & Economics Languages : en Pages : 401
Book Description
A timeless classic of economic theory that remains fascinating and pertinent today, this is Frank Knight's famous explanation of why perfect competition cannot eliminate profits, the important differences between "risk" and "uncertainty," and the vital role of the entrepreneur in profitmaking. Based on Knight's PhD dissertation, this 1921 work, balancing theory with fact to come to stunning insights, is a distinct pleasure to read. FRANK H. KNIGHT (1885-1972) is considered by some the greatest American scholar of economics of the 20th century. An economics professor at the University of Chicago from 1927 until 1955, he was one of the founders of the Chicago school of economics, which influenced Milton Friedman and George Stigler.
Author: Donald L. Price Publisher: CRC Press ISBN: 1351358804 Category : Medical Languages : en Pages : 286
Book Description
Procedure Manual for the Diagnosis of Intestinal Parasites is the definitive resource for individuals involved in the collection, preparation, and examination of fecal specimens for microscopic diagnosis of intestinal parasitic infections. The book points out the stages of parasites possibly found in a fecal specimen, how to find them, and how to identify them. Specific details on how to effectively use the microscope for parasitic diagnosis are included. This information is missing from most texts and manuals of this kind. Photomicrographs and original drawings of the various stages and forms of parasites and eggs are used extensively throughout the text, with the photomicrographs printed to a standard scale for easy comparison. More than 400 illustrations in all are included. Biological keys for intestinal amoebae and eggs of various species of helminths are provided. This book is an essential reference for teachers of diagnostic parasitology and their students, physicians who order fecal examinations for intestinal parasites, nurses or health workers who handle or prepare the specimens for the laboratory, and technologists who receive, process, and examine the specimens.
Author: Richard Bucala
Author: Richard Bucala
Author: Richard Bucala
Author: Auerbach
Author: Steve Blanding
Author: Steven F. Blanding
Author: Krishna B. Misra
Author: Tihamer Tóth
Author: Frank H. Knight
Author: Donald L. Price
Author: