Author: Robert Kelley
Publisher: Xlibris Corporation
ISBN: 1493129651
Category : Fiction
Languages : en
Pages : 143
Book Description
I'm writing this down in an attempt to make sense of the events that have unfolded. If you are reading this, it is possible you could be at risk. When my grandfather passed away, he left me the house my brother and I were raised in. I thought growing up I had learned every secret of the house, yet I am finding now, I knew very little about my grandfather and a world I never knew existed. If you take this journey with me, I must stress extreme caution. There are those who would stop at nothing to silence me. There from the core of our society. These silencers are on both sides of my gates. The information I am writing is a deep secret we all know. Yet is kept in the recesses of our mind. To keep you blinded to the truth that magic is all around you.
The Life and Times of Alexander Gates
Author: Robert Kelley
Publisher: Xlibris Corporation
ISBN: 1493129651
Category : Fiction
Languages : en
Pages : 143
Book Description
I'm writing this down in an attempt to make sense of the events that have unfolded. If you are reading this, it is possible you could be at risk. When my grandfather passed away, he left me the house my brother and I were raised in. I thought growing up I had learned every secret of the house, yet I am finding now, I knew very little about my grandfather and a world I never knew existed. If you take this journey with me, I must stress extreme caution. There are those who would stop at nothing to silence me. There from the core of our society. These silencers are on both sides of my gates. The information I am writing is a deep secret we all know. Yet is kept in the recesses of our mind. To keep you blinded to the truth that magic is all around you.
Publisher: Xlibris Corporation
ISBN: 1493129651
Category : Fiction
Languages : en
Pages : 143
Book Description
I'm writing this down in an attempt to make sense of the events that have unfolded. If you are reading this, it is possible you could be at risk. When my grandfather passed away, he left me the house my brother and I were raised in. I thought growing up I had learned every secret of the house, yet I am finding now, I knew very little about my grandfather and a world I never knew existed. If you take this journey with me, I must stress extreme caution. There are those who would stop at nothing to silence me. There from the core of our society. These silencers are on both sides of my gates. The information I am writing is a deep secret we all know. Yet is kept in the recesses of our mind. To keep you blinded to the truth that magic is all around you.
The Road Ahead
Author: Bill Gates
Publisher: Penguin Group
ISBN:
Category : Business & Economics
Languages : en
Pages : 356
Book Description
In this clear-eyed, candid, and ultimately reassuring
Publisher: Penguin Group
ISBN:
Category : Business & Economics
Languages : en
Pages : 356
Book Description
In this clear-eyed, candid, and ultimately reassuring
A Gentleman in Moscow
Author: Amor Towles
Publisher: Random House
ISBN: 1448135508
Category : Fiction
Languages : en
Pages : 547
Book Description
The mega-bestseller with more than 2 million readers Soon to be a Showtime/Paramount+ series starring Ewan McGregor as Count Alexander Rostov From the number one New York Times-bestselling author of The Lincoln Highway and Rules of Civility, a beautifully transporting novel about a man who is ordered to spend the rest of his life inside a luxury hotel 'A wonderful book' - Tana French 'This novel is astonishing, uplifting and wise. Don't miss it' - Chris Cleave 'No historical novel this year was more witty, insightful or original' - Sunday Times, Books of the Year '[A] supremely uplifting novel ... It's elegant, witty and delightful - much like the Count himself.' - Mail on Sunday, Books of the Year 'Charming ... shows that not all books about Russian aristocrats have to be full of doom and nihilism' - The Times, Books of the Year On 21 June 1922, Count Alexander Rostov - recipient of the Order of Saint Andrew, member of the Jockey Club, Master of the Hunt - is escorted out of the Kremlin, across Red Square and through the elegant revolving doors of the Hotel Metropol. Deemed an unrepentant aristocrat by a Bolshevik tribunal, the Count has been sentenced to house arrest indefinitely. But instead of his usual suite, he must now live in an attic room while Russia undergoes decades of tumultuous upheaval. Can a life without luxury be the richest of all? A BOOK OF THE DECADE, 2010-2020 (INDEPENDENT) THE TIMES BOOK OF THE YEAR 2017 A SUNDAY TIMES BOOK OF THE YEAR 2017 A MAIL ON SUNDAY BOOK OF THE YEAR 2017 A DAILY EXPRESS BOOK OF THE YEAR 2017 AN IRISH TIMES BOOK OF THE YEAR 2017 ONE OF BARACK OBAMA'S BEST BOOKS OF 2017 ONE OF BILL GATES'S SUMMER READS OF 2019 NOMINATED FOR THE 2018 INDEPENDENT BOOKSELLERS WEEK AWARD
Publisher: Random House
ISBN: 1448135508
Category : Fiction
Languages : en
Pages : 547
Book Description
The mega-bestseller with more than 2 million readers Soon to be a Showtime/Paramount+ series starring Ewan McGregor as Count Alexander Rostov From the number one New York Times-bestselling author of The Lincoln Highway and Rules of Civility, a beautifully transporting novel about a man who is ordered to spend the rest of his life inside a luxury hotel 'A wonderful book' - Tana French 'This novel is astonishing, uplifting and wise. Don't miss it' - Chris Cleave 'No historical novel this year was more witty, insightful or original' - Sunday Times, Books of the Year '[A] supremely uplifting novel ... It's elegant, witty and delightful - much like the Count himself.' - Mail on Sunday, Books of the Year 'Charming ... shows that not all books about Russian aristocrats have to be full of doom and nihilism' - The Times, Books of the Year On 21 June 1922, Count Alexander Rostov - recipient of the Order of Saint Andrew, member of the Jockey Club, Master of the Hunt - is escorted out of the Kremlin, across Red Square and through the elegant revolving doors of the Hotel Metropol. Deemed an unrepentant aristocrat by a Bolshevik tribunal, the Count has been sentenced to house arrest indefinitely. But instead of his usual suite, he must now live in an attic room while Russia undergoes decades of tumultuous upheaval. Can a life without luxury be the richest of all? A BOOK OF THE DECADE, 2010-2020 (INDEPENDENT) THE TIMES BOOK OF THE YEAR 2017 A SUNDAY TIMES BOOK OF THE YEAR 2017 A MAIL ON SUNDAY BOOK OF THE YEAR 2017 A DAILY EXPRESS BOOK OF THE YEAR 2017 AN IRISH TIMES BOOK OF THE YEAR 2017 ONE OF BARACK OBAMA'S BEST BOOKS OF 2017 ONE OF BILL GATES'S SUMMER READS OF 2019 NOMINATED FOR THE 2018 INDEPENDENT BOOKSELLERS WEEK AWARD
Range
Author: David Epstein
Publisher: Penguin
ISBN: 0735214506
Category : Psychology
Languages : en
Pages : 369
Book Description
The #1 New York Times bestseller that has all America talking—with a new afterword on expanding your range—as seen on CNN's Fareed Zakaria GPS, Morning Joe, CBS This Morning, and more. “The most important business—and parenting—book of the year.” —Forbes “Urgent and important. . . an essential read for bosses, parents, coaches, and anyone who cares about improving performance.” —Daniel H. Pink Shortlisted for the Financial Times/McKinsey Business Book of the Year Award Plenty of experts argue that anyone who wants to develop a skill, play an instrument, or lead their field should start early, focus intensely, and rack up as many hours of deliberate practice as possible. If you dabble or delay, you’ll never catch up to the people who got a head start. But a closer look at research on the world’s top performers, from professional athletes to Nobel laureates, shows that early specialization is the exception, not the rule. David Epstein examined the world’s most successful athletes, artists, musicians, inventors, forecasters and scientists. He discovered that in most fields—especially those that are complex and unpredictable—generalists, not specialists, are primed to excel. Generalists often find their path late, and they juggle many interests rather than focusing on one. They’re also more creative, more agile, and able to make connections their more specialized peers can’t see. Provocative, rigorous, and engrossing, Range makes a compelling case for actively cultivating inefficiency. Failing a test is the best way to learn. Frequent quitters end up with the most fulfilling careers. The most impactful inventors cross domains rather than deepening their knowledge in a single area. As experts silo themselves further while computers master more of the skills once reserved for highly focused humans, people who think broadly and embrace diverse experiences and perspectives will increasingly thrive.
Publisher: Penguin
ISBN: 0735214506
Category : Psychology
Languages : en
Pages : 369
Book Description
The #1 New York Times bestseller that has all America talking—with a new afterword on expanding your range—as seen on CNN's Fareed Zakaria GPS, Morning Joe, CBS This Morning, and more. “The most important business—and parenting—book of the year.” —Forbes “Urgent and important. . . an essential read for bosses, parents, coaches, and anyone who cares about improving performance.” —Daniel H. Pink Shortlisted for the Financial Times/McKinsey Business Book of the Year Award Plenty of experts argue that anyone who wants to develop a skill, play an instrument, or lead their field should start early, focus intensely, and rack up as many hours of deliberate practice as possible. If you dabble or delay, you’ll never catch up to the people who got a head start. But a closer look at research on the world’s top performers, from professional athletes to Nobel laureates, shows that early specialization is the exception, not the rule. David Epstein examined the world’s most successful athletes, artists, musicians, inventors, forecasters and scientists. He discovered that in most fields—especially those that are complex and unpredictable—generalists, not specialists, are primed to excel. Generalists often find their path late, and they juggle many interests rather than focusing on one. They’re also more creative, more agile, and able to make connections their more specialized peers can’t see. Provocative, rigorous, and engrossing, Range makes a compelling case for actively cultivating inefficiency. Failing a test is the best way to learn. Frequent quitters end up with the most fulfilling careers. The most impactful inventors cross domains rather than deepening their knowledge in a single area. As experts silo themselves further while computers master more of the skills once reserved for highly focused humans, people who think broadly and embrace diverse experiences and perspectives will increasingly thrive.
The Great Influenza
Author: John M. Barry
Publisher: Penguin
ISBN: 9780143036494
Category : History
Languages : en
Pages : 580
Book Description
#1 New York Times bestseller “Barry will teach you almost everything you need to know about one of the deadliest outbreaks in human history.”—Bill Gates "Monumental... an authoritative and disturbing morality tale."—Chicago Tribune The strongest weapon against pandemic is the truth. Read why in the definitive account of the 1918 Flu Epidemic. Magisterial in its breadth of perspective and depth of research, The Great Influenza provides us with a precise and sobering model as we confront the epidemics looming on our own horizon. As Barry concludes, "The final lesson of 1918, a simple one yet one most difficult to execute, is that...those in authority must retain the public's trust. The way to do that is to distort nothing, to put the best face on nothing, to try to manipulate no one. Lincoln said that first, and best. A leader must make whatever horror exists concrete. Only then will people be able to break it apart." At the height of World War I, history’s most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease.
Publisher: Penguin
ISBN: 9780143036494
Category : History
Languages : en
Pages : 580
Book Description
#1 New York Times bestseller “Barry will teach you almost everything you need to know about one of the deadliest outbreaks in human history.”—Bill Gates "Monumental... an authoritative and disturbing morality tale."—Chicago Tribune The strongest weapon against pandemic is the truth. Read why in the definitive account of the 1918 Flu Epidemic. Magisterial in its breadth of perspective and depth of research, The Great Influenza provides us with a precise and sobering model as we confront the epidemics looming on our own horizon. As Barry concludes, "The final lesson of 1918, a simple one yet one most difficult to execute, is that...those in authority must retain the public's trust. The way to do that is to distort nothing, to put the best face on nothing, to try to manipulate no one. Lincoln said that first, and best. A leader must make whatever horror exists concrete. Only then will people be able to break it apart." At the height of World War I, history’s most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease.
The Vital Question
Author: Nick Lane
Publisher:
ISBN: 9781781250372
Category : Cells
Languages : en
Pages : 0
Book Description
A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.
Publisher:
ISBN: 9781781250372
Category : Cells
Languages : en
Pages : 0
Book Description
A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.
Alexander the Great
Author: Anthony Everitt
Publisher: Random House Trade Paperbacks
ISBN: 0425286533
Category : History
Languages : en
Pages : 505
Book Description
What can we learn from the stunning rise and mysterious death of the ancient world’s greatest conqueror? An acclaimed biographer reconstructs the life of Alexander the Great in this magisterial revisionist portrait. “[An] infectious sense of narrative momentum . . . Its energy is unflagging, including the verve with which it tackles that teased final mystery about the specific cause of Alexander’s death.”—The Christian Science Monitor More than two millennia have passed since Alexander the Great built an empire that stretched to every corner of the ancient world, from the backwater kingdom of Macedonia to the Hellenic world, Persia, and ultimately to India—all before his untimely death at age thirty-three. Alexander believed that his empire would stop only when he reached the Pacific Ocean. But stories of both real and legendary events from his life have kept him evergreen in our imaginations with a legacy that has meant something different to every era: in the Middle Ages he became an exemplar of knightly chivalry, he was a star of Renaissance paintings, and by the early twentieth century he’d even come to resemble an English gentleman. But who was he in his own time? In Alexander the Great, Anthony Everitt judges Alexander’s life against the criteria of his own age and considers all his contradictions. We meet the Macedonian prince who was naturally inquisitive and fascinated by science and exploration, as well as the man who enjoyed the arts and used Homer’s great epic the Iliad as a bible. As his empire grew, Alexander exhibited respect for the traditions of his new subjects and careful judgment in administering rule over his vast territory. But his career also had a dark side. An inveterate conqueror who in his short life built the largest empire up to that point in history, Alexander glorified war and was known to commit acts of remarkable cruelty. As debate continues about the meaning of his life, Alexander's death remains a mystery. Did he die of natural causes—felled by a fever—or did his marshals, angered by his tyrannical behavior, kill him? An explanation of his death can lie only in what we know of his life, and Everitt ventures to solve that puzzle, offering an ending to Alexander’s story that has eluded so many for so long.
Publisher: Random House Trade Paperbacks
ISBN: 0425286533
Category : History
Languages : en
Pages : 505
Book Description
What can we learn from the stunning rise and mysterious death of the ancient world’s greatest conqueror? An acclaimed biographer reconstructs the life of Alexander the Great in this magisterial revisionist portrait. “[An] infectious sense of narrative momentum . . . Its energy is unflagging, including the verve with which it tackles that teased final mystery about the specific cause of Alexander’s death.”—The Christian Science Monitor More than two millennia have passed since Alexander the Great built an empire that stretched to every corner of the ancient world, from the backwater kingdom of Macedonia to the Hellenic world, Persia, and ultimately to India—all before his untimely death at age thirty-three. Alexander believed that his empire would stop only when he reached the Pacific Ocean. But stories of both real and legendary events from his life have kept him evergreen in our imaginations with a legacy that has meant something different to every era: in the Middle Ages he became an exemplar of knightly chivalry, he was a star of Renaissance paintings, and by the early twentieth century he’d even come to resemble an English gentleman. But who was he in his own time? In Alexander the Great, Anthony Everitt judges Alexander’s life against the criteria of his own age and considers all his contradictions. We meet the Macedonian prince who was naturally inquisitive and fascinated by science and exploration, as well as the man who enjoyed the arts and used Homer’s great epic the Iliad as a bible. As his empire grew, Alexander exhibited respect for the traditions of his new subjects and careful judgment in administering rule over his vast territory. But his career also had a dark side. An inveterate conqueror who in his short life built the largest empire up to that point in history, Alexander glorified war and was known to commit acts of remarkable cruelty. As debate continues about the meaning of his life, Alexander's death remains a mystery. Did he die of natural causes—felled by a fever—or did his marshals, angered by his tyrannical behavior, kill him? An explanation of his death can lie only in what we know of his life, and Everitt ventures to solve that puzzle, offering an ending to Alexander’s story that has eluded so many for so long.
Energy and Civilization
Author: Vaclav Smil
Publisher: MIT Press
ISBN: 0262536161
Category : Science
Languages : en
Pages : 564
Book Description
A comprehensive account of how energy has shaped society throughout history, from pre-agricultural foraging societies through today's fossil fuel–driven civilization. "I wait for new Smil books the way some people wait for the next 'Star Wars' movie. In his latest book, Energy and Civilization: A History, he goes deep and broad to explain how innovations in humans' ability to turn energy into heat, light, and motion have been a driving force behind our cultural and economic progress over the past 10,000 years. —Bill Gates, Gates Notes, Best Books of the Year Energy is the only universal currency; it is necessary for getting anything done. The conversion of energy on Earth ranges from terra-forming forces of plate tectonics to cumulative erosive effects of raindrops. Life on Earth depends on the photosynthetic conversion of solar energy into plant biomass. Humans have come to rely on many more energy flows—ranging from fossil fuels to photovoltaic generation of electricity—for their civilized existence. In this monumental history, Vaclav Smil provides a comprehensive account of how energy has shaped society, from pre-agricultural foraging societies through today's fossil fuel–driven civilization. Humans are the only species that can systematically harness energies outside their bodies, using the power of their intellect and an enormous variety of artifacts—from the simplest tools to internal combustion engines and nuclear reactors. The epochal transition to fossil fuels affected everything: agriculture, industry, transportation, weapons, communication, economics, urbanization, quality of life, politics, and the environment. Smil describes humanity's energy eras in panoramic and interdisciplinary fashion, offering readers a magisterial overview. This book is an extensively updated and expanded version of Smil's Energy in World History (1994). Smil has incorporated an enormous amount of new material, reflecting the dramatic developments in energy studies over the last two decades and his own research over that time.
Publisher: MIT Press
ISBN: 0262536161
Category : Science
Languages : en
Pages : 564
Book Description
A comprehensive account of how energy has shaped society throughout history, from pre-agricultural foraging societies through today's fossil fuel–driven civilization. "I wait for new Smil books the way some people wait for the next 'Star Wars' movie. In his latest book, Energy and Civilization: A History, he goes deep and broad to explain how innovations in humans' ability to turn energy into heat, light, and motion have been a driving force behind our cultural and economic progress over the past 10,000 years. —Bill Gates, Gates Notes, Best Books of the Year Energy is the only universal currency; it is necessary for getting anything done. The conversion of energy on Earth ranges from terra-forming forces of plate tectonics to cumulative erosive effects of raindrops. Life on Earth depends on the photosynthetic conversion of solar energy into plant biomass. Humans have come to rely on many more energy flows—ranging from fossil fuels to photovoltaic generation of electricity—for their civilized existence. In this monumental history, Vaclav Smil provides a comprehensive account of how energy has shaped society, from pre-agricultural foraging societies through today's fossil fuel–driven civilization. Humans are the only species that can systematically harness energies outside their bodies, using the power of their intellect and an enormous variety of artifacts—from the simplest tools to internal combustion engines and nuclear reactors. The epochal transition to fossil fuels affected everything: agriculture, industry, transportation, weapons, communication, economics, urbanization, quality of life, politics, and the environment. Smil describes humanity's energy eras in panoramic and interdisciplinary fashion, offering readers a magisterial overview. This book is an extensively updated and expanded version of Smil's Energy in World History (1994). Smil has incorporated an enormous amount of new material, reflecting the dramatic developments in energy studies over the last two decades and his own research over that time.
Under a White Sky
Author: Elizabeth Kolbert
Publisher: Crown
ISBN: 0593136292
Category : Science
Languages : en
Pages : 273
Book Description
NATIONAL BESTSELLER • The Pulitzer Prize–winning author of The Sixth Extinction returns to humanity’s transformative impact on the environment, now asking: After doing so much damage, can we change nature, this time to save it? RECOMMENDED BY PRESIDENT OBAMA AND BILL GATES • SHORTLISTED FOR THE WAINWRIGHT PRIZE FOR WRITING • ONE OF THE TEN BEST BOOKS OF THE YEAR: The Washington Post • ONE OF THE BEST BOOKS OF THE YEAR: Time, Esquire, Smithsonian Magazine, Vulture, Publishers Weekly, Kirkus Reviews, Library Journal • “Beautifully and insistently, Kolbert shows us that it is time to think radically about the ways we manage the environment.”—Helen Macdonald, The New York Times That man should have dominion “over all the earth, and over every creeping thing that creepeth upon the earth” is a prophecy that has hardened into fact. So pervasive are human impacts on the planet that it’s said we live in a new geological epoch: the Anthropocene. In Under a White Sky, Elizabeth Kolbert takes a hard look at the new world we are creating. Along the way, she meets biologists who are trying to preserve the world’s rarest fish, which lives in a single tiny pool in the middle of the Mojave; engineers who are turning carbon emissions to stone in Iceland; Australian researchers who are trying to develop a “super coral” that can survive on a hotter globe; and physicists who are contemplating shooting tiny diamonds into the stratosphere to cool the earth. One way to look at human civilization, says Kolbert, is as a ten-thousand-year exercise in defying nature. In The Sixth Extinction, she explored the ways in which our capacity for destruction has reshaped the natural world. Now she examines how the very sorts of interventions that have imperiled our planet are increasingly seen as the only hope for its salvation. By turns inspiring, terrifying, and darkly comic, Under a White Sky is an utterly original examination of the challenges we face.
Publisher: Crown
ISBN: 0593136292
Category : Science
Languages : en
Pages : 273
Book Description
NATIONAL BESTSELLER • The Pulitzer Prize–winning author of The Sixth Extinction returns to humanity’s transformative impact on the environment, now asking: After doing so much damage, can we change nature, this time to save it? RECOMMENDED BY PRESIDENT OBAMA AND BILL GATES • SHORTLISTED FOR THE WAINWRIGHT PRIZE FOR WRITING • ONE OF THE TEN BEST BOOKS OF THE YEAR: The Washington Post • ONE OF THE BEST BOOKS OF THE YEAR: Time, Esquire, Smithsonian Magazine, Vulture, Publishers Weekly, Kirkus Reviews, Library Journal • “Beautifully and insistently, Kolbert shows us that it is time to think radically about the ways we manage the environment.”—Helen Macdonald, The New York Times That man should have dominion “over all the earth, and over every creeping thing that creepeth upon the earth” is a prophecy that has hardened into fact. So pervasive are human impacts on the planet that it’s said we live in a new geological epoch: the Anthropocene. In Under a White Sky, Elizabeth Kolbert takes a hard look at the new world we are creating. Along the way, she meets biologists who are trying to preserve the world’s rarest fish, which lives in a single tiny pool in the middle of the Mojave; engineers who are turning carbon emissions to stone in Iceland; Australian researchers who are trying to develop a “super coral” that can survive on a hotter globe; and physicists who are contemplating shooting tiny diamonds into the stratosphere to cool the earth. One way to look at human civilization, says Kolbert, is as a ten-thousand-year exercise in defying nature. In The Sixth Extinction, she explored the ways in which our capacity for destruction has reshaped the natural world. Now she examines how the very sorts of interventions that have imperiled our planet are increasingly seen as the only hope for its salvation. By turns inspiring, terrifying, and darkly comic, Under a White Sky is an utterly original examination of the challenges we face.
Breath from Salt
Author: Bijal P. Trivedi
Publisher: BenBella Books
ISBN: 1948836629
Category : Medical
Languages : en
Pages : 744
Book Description
Recommended by Bill Gates and included in GatesNotes "Elaborating on the science as well as the business behind the fight against cystic fibrosis, Trivedi captures the emotions of the families, doctors, and scientists involved in the clinical trials and their 'weeping with joy' as new drugs are approved, and shows how cystic fibrosis, once a 'death sentence,' became, for many, a manageable condition. This is a rewarding and challenging work." —Publishers Weekly Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday. The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease. From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.
Publisher: BenBella Books
ISBN: 1948836629
Category : Medical
Languages : en
Pages : 744
Book Description
Recommended by Bill Gates and included in GatesNotes "Elaborating on the science as well as the business behind the fight against cystic fibrosis, Trivedi captures the emotions of the families, doctors, and scientists involved in the clinical trials and their 'weeping with joy' as new drugs are approved, and shows how cystic fibrosis, once a 'death sentence,' became, for many, a manageable condition. This is a rewarding and challenging work." —Publishers Weekly Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday. The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease. From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.