The Emperor of All Maladies PDF Download

Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
ISBN: 1439170916
Category : Health & Fitness
Languages : en
Pages : 624

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Book Description
Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
ISBN: 147678485X
Category : Medical
Languages : en
Pages : 96

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Book Description
Essential, required reading for doctors and patients alike: A Pulitzer Prize-winning author and one of the world’s premiere cancer researchers reveals an urgent philosophy on the little-known principles that govern medicine—and how understanding these principles can empower us all. Over a decade ago, when Siddhartha Mukherjee was a young, exhausted, and isolated medical resident, he discovered a book that would forever change the way he understood the medical profession. The book, The Youngest Science, forced Dr. Mukherjee to ask himself an urgent, fundamental question: Is medicine a “science”? Sciences must have laws—statements of truth based on repeated experiments that describe some universal attribute of nature. But does medicine have laws like other sciences? Dr. Mukherjee has spent his career pondering this question—a question that would ultimately produce some of most serious thinking he would do around the tenets of his discipline—culminating in The Laws of Medicine. In this important treatise, he investigates the most perplexing and illuminating cases of his career that ultimately led him to identify the three key principles that govern medicine. Brimming with fascinating historical details and modern medical wonders, this important book is a fascinating glimpse into the struggles and Eureka! moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee’s signature eloquence and passionate prose, The Laws of Medicine is a critical read, not just for those in the medical profession, but for everyone who is moved to better understand how their health and well-being is being treated. Ultimately, this book lays the groundwork for a new way of understanding medicine, now and into the future.

Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
ISBN: 1476733538
Category : Medical
Languages : en
Pages : 624

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Book Description
The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
ISBN: 1982117370
Category : Medical
Languages : en
Pages : 496

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Winner of the 2023 PROSE Award for Excellence in Biological and Life Sciences and the 2023 Chautauqua Prize! Named a New York Times Notable Book and a Best Book of the Year by The Economist, Oprah Daily, BookPage, Book Riot, the New York Public Library, and more! In The Song of the Cell, the extraordinary author of the Pulitzer Prize–winning The Emperor of All Maladies and the #1 New York Times bestseller The Gene “blends cutting-edge research, impeccable scholarship, intrepid reporting, and gorgeous prose into an encyclopedic study that reads like a literary page-turner” (Oprah Daily). Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christened them “cells.” The discovery of cells—and the reframing of the human body as a cellular ecosystem—announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer’s dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia—all could be reconceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies. Filled with writing so vivid, lucid, and suspenseful that complex science becomes thrilling, The Song of the Cell tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. Told in six parts, and laced with Mukherjee’s own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate—a masterpiece on what it means to be human. “In an account both lyrical and capacious, Mukherjee takes us through an evolution of human understanding: from the seventeenth-century discovery that humans are made up of cells to our cutting-edge technologies for manipulating and deploying cells for therapeutic purposes” (The New Yorker).

Author: Jhumpa Lahiri
Publisher: Houghton Mifflin Harcourt
ISBN: 039592720X
Category : Fiction
Languages : en
Pages : 202

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Book Description
Navigating between the Indian traditions they've inherited and a baffling new world, the characters in Lahiri's elegant, touching stories seek love beyond the barriers of culture and generations.

Author: Jonathan Weiner
Publisher: Harper Collins
ISBN: 0062000217
Category : Science
Languages : en
Pages : 322

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“[A] searching and surprisingly witty look at the scientific odds against tomorrow.” —Timothy Ferris Jonathan Weiner—winner of the Pulitzer Prize, the National Book Critics Circle Award, and the Los Angeles Times Book Prize, and one of the most distinguished popular science writers in America—examines “the strange science of immortality” in Long for This World. A fast-paced, sure-to-astonish scientific adventure from “one of our finest science journalists” (Jonah Lehrer), Weiner’s Long for This World addresses the ageless question, “Is there a secret to eternal youth?” And has it, at long last, been found?

Author: Jessica Wapner
Publisher: The Experiment, LLC
ISBN: 1615191658
Category : Health & Fitness
Languages : en
Pages : 345

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One of The Wall Street Journal’s 10 Best Nonfiction Books of the Year Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

Author: Robert A Weinberg
Publisher: Basic Books
ISBN: 0786724013
Category : Science
Languages : en
Pages : 180

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Book Description
Cancer research has reached a major turning point. The quality and quantity of information gathered about this disease in the past twenty years has revolutionized our understanding of its origins and behavior. No one is better qualified to comment on these dramatic leaps forward than molecular biologist Robert A. Weinberg, director of one of the leading cancer research centers in the world. In One Renegade Cell , Weinberg presents an accessible and state-of-the-art account of how the disease begins and how, one day, it will be cured. Weinberg tells how the roots of cancer were uncovered in 1909 and when the first cancer-causing virus was discovered. He then moves forward to the discovery of the role of chemical carcinogens and radiation in triggering cancer, and relates the remarkable story of the discoveries of oncogenes and tumor suppressor genes, the master controllers of normal and malignant cell proliferation. This book, which presumes little prior knowledge of biology, describes the revolution in biomedical research that has finally uncovered the forces driving malignant growth. Drawing on insights that simply were not available until recently, the discoveries presented in One Renegade Cell have already begun to profoundly alter the way that we diagnose and treat human cancers.

Author: David Fajgenbaum
Publisher: Ballantine Books
ISBN: 1524799629
Category : Biography & Autobiography
Languages : en
Pages : 266

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LOS ANGELES TIMES AND PUBLISHERS WEEKLY BESTSELLER • The powerful memoir of a young doctor and former college athlete diagnosed with a rare disease who spearheaded the search for a cure—and became a champion for a new approach to medical research. “A wonderful and moving chronicle of a doctor’s relentless pursuit, this book serves both patients and physicians in demystifying the science that lies behind medicine.”—Siddhartha Mukherjee, New York Times bestselling author of The Emperor of All Maladies and The Gene David Fajgenbaum, a former Georgetown quarterback, was nicknamed the Beast in medical school, where he was also known for his unmatched mental stamina. But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime. Miraculously, Fajgenbaum survived—only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself. More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide. Praise for Chasing My Cure “A page-turning chronicle of living, nearly dying, and discovering what it really means to be invincible in hope.”—Angela Duckworth, #1 New York Times bestselling author of Grit “[A] remarkable memoir . . . Fajgenbaum writes lucidly and movingly . . . Fajgenbaum’s stirring account of his illness will inspire readers.”—Publishers Weekly

Author: Dan Fagin
Publisher: Bantam
ISBN: 0345538617
Category : Science
Languages : en
Pages : 562

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WINNER OF THE PULITZER PRIZE • Winner of The New York Public Library’s Helen Bernstein Book Award • “A new classic of science reporting.”—The New York Times The riveting true story of a small town ravaged by industrial pollution, Toms River melds hard-hitting investigative reporting, a fascinating scientific detective story, and an unforgettable cast of characters into a sweeping narrative in the tradition of A Civil Action, The Emperor of All Maladies, and The Immortal Life of Henrietta Lacks. One of New Jersey’s seemingly innumerable quiet seaside towns, Toms River became the unlikely setting for a decades-long drama that culminated in 2001 with one of the largest legal settlements in the annals of toxic dumping. A town that would rather have been known for its Little League World Series champions ended up making history for an entirely different reason: a notorious cluster of childhood cancers scientifically linked to local air and water pollution. For years, large chemical companies had been using Toms River as their private dumping ground, burying tens of thousands of leaky drums in open pits and discharging billions of gallons of acid-laced wastewater into the town’s namesake river. In an astonishing feat of investigative reporting, prize-winning journalist Dan Fagin recounts the sixty-year saga of rampant pollution and inadequate oversight that made Toms River a cautionary example for fast-growing industrial towns from South Jersey to South China. He tells the stories of the pioneering scientists and physicians who first identified pollutants as a cause of cancer, and brings to life the everyday heroes in Toms River who struggled for justice: a young boy whose cherubic smile belied the fast-growing tumors that had decimated his body from birth; a nurse who fought to bring the alarming incidence of childhood cancers to the attention of authorities who didn’t want to listen; and a mother whose love for her stricken child transformed her into a tenacious advocate for change. A gripping human drama rooted in a centuries-old scientific quest, Toms River is a tale of dumpers at midnight and deceptions in broad daylight, of corporate avarice and government neglect, and of a few brave individuals who refused to keep silent until the truth was exposed. NAMED ONE OF THE BEST BOOKS OF THE YEAR BY NPR AND KIRKUS REVIEWS “A thrilling journey full of twists and turns, Toms River is essential reading for our times. Dan Fagin handles topics of great complexity with the dexterity of a scholar, the honesty of a journalist, and the dramatic skill of a novelist.”—Siddhartha Mukherjee, M.D., author of the Pulitzer Prize–winning The Emperor of All Maladies “A complex tale of powerful industry, local politics, water rights, epidemiology, public health and cancer in a gripping, page-turning environmental thriller.”—NPR “Unstoppable reading.”—The Philadelphia Inquirer “Meticulously researched and compellingly recounted . . . It’s every bit as important—and as well-written—as A Civil Action and The Immortal Life of Henrietta Lacks.”—The Star-Ledger “Fascinating . . . a gripping environmental thriller.”—Kirkus Reviews (starred review) “An honest, thoroughly researched, intelligently written book.”—Slate “[A] hard-hitting account . . . a triumph.”—Nature “Absorbing and thoughtful.”—USA Today