The Discovery of the Cellular Sodium Pump in the 20th Century PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Discovery of the Cellular Sodium Pump in the 20th Century PDF full book. Access full book title The Discovery of the Cellular Sodium Pump in the 20th Century by Beatrice Maier Anner. Download full books in PDF and EPUB format.
Author: Beatrice Maier Anner Publisher: GRIN Verlag ISBN: 3963558636 Category : Science Languages : en Pages : 49
Book Description
Document from the year 2024 in the subject Chemistry - Bio-chemistry, , language: English, abstract: During her doctoral and postdoctoral studies, Beatrice Maier Anner became familiar with a fascinating biological system, called sodium pump by the physiologists and Na,K-ATPase by the biochemists; it is a sort of biomotor located in the cell membrane, which constantly expulses sodium (Na) ions from the cell interior and replaces them by potassium (K) ions, at the expense of chemical energy provided by adenosine-triphosphate (ATP) which is cleaved to adenosine-diphosphate (ADP) by the Na,K-ATPase, which gets its pump energy from the cleavage of this chemical bond. There would be no life without this fundamental biological system. Interestingly, it is also a pharmacological receptor, i.e. compounds extracted from the Digitalis plant of from the toad bind to the pump and block it, hence the toxicity of e.g. digitoxin or the toad's bufotoxins. The author has acquired extensive practical and theoretical knowledge of this biological system, acquired at the Baylor College of Medicine, Houston, TX, USA consisting in inserting purified functional Na,K-ATPase into artificial membranes (liposomes) in order to study the pump activity on a molecular level. The present book is a unique historical overview from the discovery and purification of the sodium pump to its reconstitution in artificial membranes in the 20th century. This short book permits to become rapidly familiar with this fascinating biomotor and to find unique historical sources.
Author: Beatrice Maier Anner Publisher: GRIN Verlag ISBN: 3963558636 Category : Science Languages : en Pages : 49
Book Description
Document from the year 2024 in the subject Chemistry - Bio-chemistry, , language: English, abstract: During her doctoral and postdoctoral studies, Beatrice Maier Anner became familiar with a fascinating biological system, called sodium pump by the physiologists and Na,K-ATPase by the biochemists; it is a sort of biomotor located in the cell membrane, which constantly expulses sodium (Na) ions from the cell interior and replaces them by potassium (K) ions, at the expense of chemical energy provided by adenosine-triphosphate (ATP) which is cleaved to adenosine-diphosphate (ADP) by the Na,K-ATPase, which gets its pump energy from the cleavage of this chemical bond. There would be no life without this fundamental biological system. Interestingly, it is also a pharmacological receptor, i.e. compounds extracted from the Digitalis plant of from the toad bind to the pump and block it, hence the toxicity of e.g. digitoxin or the toad's bufotoxins. The author has acquired extensive practical and theoretical knowledge of this biological system, acquired at the Baylor College of Medicine, Houston, TX, USA consisting in inserting purified functional Na,K-ATPase into artificial membranes (liposomes) in order to study the pump activity on a molecular level. The present book is a unique historical overview from the discovery and purification of the sodium pump to its reconstitution in artificial membranes in the 20th century. This short book permits to become rapidly familiar with this fascinating biomotor and to find unique historical sources.
Author: Jean-Daniel Horisberger Publisher: R. G. Landes ISBN: Category : Medical Languages : en Pages : 148
Book Description
This text addresses the question, How does the sodium pump pump'. A variety of primary structure information is available, and progress has been made in the functional characterization of the Na, K-pump, making the answer to this question possible, within reach of currently used techniques
Author: Ernst Bamberg Publisher: Springer Science & Business Media ISBN: 3642725112 Category : Medical Languages : en Pages : 924
Book Description
The sodium of animal cell membranes converts the chemical energy obtained from the hydrolysis of adenosine 5' -triphosphate into a movement of the cations Na + and K + against an electrochemical gradient. The gradient is used subse quently as an energy source to drive the uptake of metabolic substrates in polar epithelial cells and to use it for purposes of communications in excitable cells. The biological importance of the sodium pump is evident from the fact that be tween 20-70% of the cell's metabolic energy is consumed for the pumping pro cess. Moreover, the sodium pump is an important biological system involved in regulatory processes like the maintenance of the cells' and organism's water me tabolism. It is therefore understandable that special cellular demands are han dled better by special isoforms of the sodium pump, that the expression of the sodium pump and their isoforms is regulated by hormones as is the activity of the sodium pump via hormone-regulated protein kinases. Additionally, the sodium pump itself seems to be a receptor for a putative new group of hormones, the endogenous digitalis-like substances, which still have to be defined in most cases in their structure. This group of substances has its chemically well known coun terpart in steroids from plant and toad origin which are generally known as "car diac glycosides". They are in medical use since at least 200 years in medicine in the treatment of heart diseases.
Author: Andrei I. Ivanov Publisher: Springer Science & Business Media ISBN: 1588298655 Category : Medical Languages : en Pages : 407
Book Description
In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.
Author: Michel Félétou Publisher: Morgan & Claypool Publishers ISBN: 1615041230 Category : Science Languages : en Pages : 309
Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author: Bertil Hille Publisher: Sinauer Associates, Incorporated ISBN: Category : Medical Languages : en Pages : 638
Book Description
This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
Author: Michael Bliss Publisher: University of Toronto Press ISBN: 1487516746 Category : Medical Languages : en Pages : 320
Book Description
The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.
Author: Irwin B. Levitan Publisher: Oxford University Press, USA ISBN: 9780195145236 Category : Molecular neurobiology Languages : en Pages : 640
Book Description
Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.
Author: Charles Tanford Publisher: OUP Oxford ISBN: 0191578517 Category : Science Languages : en Pages : 312
Book Description
Proteins are amazingly versatile molecules. They make the chemical reactions happen that form the basis for life, they transmit signals in the body, they identify and kill foreign invaders, they form the engines that make us move, and they record visual images. All of this is now common knowledge, but it was not so a hundred years ago. Nature's Robots is an authoritative history of protein science, from the origins of protein research in the nineteenth century, when the chemical constitution of 'protein' was first studied and heatedly debated and when there was as yet no glimmer of the functional potential of substances in the 'protein' category, to the determination of the first structures of individual proteins at atomic resolution - when positions of individual atoms were first specified exactly and bonding between neighbouring atoms precisely defined. Tanford and Reynolds, who themselves made major contributions to the golden age of protein science, have written a remarkably vivid account of this history. It is a fascinating story, involving heroes from the past, working mostly alone or in small groups, usually with little support from formal research groups. It is also a story that embraces a number of historically important scientific controversies. Written in clear and accessible prose, Nature's Robots will appeal to general readers with an interest in popular science, in addition to professional scientists and historians of science.
Author: Beatrice Maier Anner
Author: Beatrice Maier Anner
Author: Jean-Daniel Horisberger
Author: Ernst Bamberg
Author: Andrei I. Ivanov
Author: Michel Félétou
Author: Bruce Alberts
Author: Bertil Hille
Author: Michael Bliss
Author: Irwin B. Levitan
Author: Charles Tanford