Author: Maria Stefania Sinicropi
Publisher: Mdpi AG
ISBN: 9783036512990
Category : Science
Languages : en
Pages : 218
Book Description
The book explores issues concerning the design, synthetic methods and biological evaluation of molecules of pharmaceutical interest.
The Design, Synthesis and Biological Evaluation of Compounds with Medicinal Value
Author: Maria Stefania Sinicropi
Publisher: Mdpi AG
ISBN: 9783036512990
Category : Science
Languages : en
Pages : 218
Book Description
The book explores issues concerning the design, synthetic methods and biological evaluation of molecules of pharmaceutical interest.
Publisher: Mdpi AG
ISBN: 9783036512990
Category : Science
Languages : en
Pages : 218
Book Description
The book explores issues concerning the design, synthetic methods and biological evaluation of molecules of pharmaceutical interest.
The Design, Synthesis, and Biological Evaluation of Compounds with Medicinal Value
Author: Maria Sinicropi
Publisher:
ISBN: 9783036513003
Category :
Languages : en
Pages : 218
Book Description
The book explores issues concerning the design, synthetic methods and biological evaluation of molecules of pharmaceutical interest.
Publisher:
ISBN: 9783036513003
Category :
Languages : en
Pages : 218
Book Description
The book explores issues concerning the design, synthetic methods and biological evaluation of molecules of pharmaceutical interest.
The Design, Synthesis, and Biological Evaluation of Compounds with Medicinal Value
Author: Maria Sinicropi
Publisher:
ISBN: 9783036513003
Category :
Languages : en
Pages : 218
Book Description
The book explores issues concerning the design, synthetic methods and biological evaluation of molecules of pharmaceutical interest.
Publisher:
ISBN: 9783036513003
Category :
Languages : en
Pages : 218
Book Description
The book explores issues concerning the design, synthetic methods and biological evaluation of molecules of pharmaceutical interest.
The Design, Synthesis, and Biological Evaluation of Novel Taxotere Analogs
Privileged Scaffolds in Medicinal Chemistry
Author: Stefan Bräse
Publisher: Royal Society of Chemistry
ISBN: 1782620303
Category : Medical
Languages : en
Pages : 486
Book Description
This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.
Publisher: Royal Society of Chemistry
ISBN: 1782620303
Category : Medical
Languages : en
Pages : 486
Book Description
This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.
Modern Green Chemistry and Heterocyclic Compounds
Author: Ravindra S. Shinde
Publisher:
ISBN: 9780429328602
Category : Green chemistry
Languages : en
Pages :
Book Description
"This book covers the general properties of heterocyclic compounds and methods for their preparation to use in applications of green chemistry. Heterocyclic compounds are an important class of molecules in organic chemistry due to their presence in natural products and their use in pharmaceuticals and new materials. They also play a vital role in the metabolism of living cells. Heterocyclic compounds have a wide range of applications in agrochemicals, pharmaceuticals, veterinary products, etc. This research-oriented volume, Modern Green Chemistry and Heterocyclic Compounds: Molecular Design, Synthesis, and Biological Evaluation, is ideal for readers who want to fully realize the almost limitless potential of heterocyclic compounds and to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features several case studies and step-by-step descriptions of synthetic methods and practical techniques. It also serves as a guide for chemists, offering them new insights and new paths to explore for effective drug discovery"--
Publisher:
ISBN: 9780429328602
Category : Green chemistry
Languages : en
Pages :
Book Description
"This book covers the general properties of heterocyclic compounds and methods for their preparation to use in applications of green chemistry. Heterocyclic compounds are an important class of molecules in organic chemistry due to their presence in natural products and their use in pharmaceuticals and new materials. They also play a vital role in the metabolism of living cells. Heterocyclic compounds have a wide range of applications in agrochemicals, pharmaceuticals, veterinary products, etc. This research-oriented volume, Modern Green Chemistry and Heterocyclic Compounds: Molecular Design, Synthesis, and Biological Evaluation, is ideal for readers who want to fully realize the almost limitless potential of heterocyclic compounds and to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features several case studies and step-by-step descriptions of synthetic methods and practical techniques. It also serves as a guide for chemists, offering them new insights and new paths to explore for effective drug discovery"--
Molecular Diversity in Drug Discovery
Anticancer Agents
Author: Qiao-Hong Chen
Publisher: MDPI
ISBN: 3036501401
Category : Business & Economics
Languages : en
Pages : 606
Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Publisher: MDPI
ISBN: 3036501401
Category : Business & Economics
Languages : en
Pages : 606
Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Bioactive Heterocycles
Author: K. L. Ameta
Publisher: Nova Science Publishers
ISBN: 9781622576364
Category : Bioactive compounds
Languages : en
Pages : 0
Book Description
This book is a critical and lucid account of various synthetic methodologies and biological activities of different sized bioactive heterocyclic compounds. In effect, this book imparts a great deal of comprehensive reviews about the chemistry and biology of selected groups of heterocycles and natural products including important pharmaceuticals as well as agrochemical pesticides in one handy project. Besides, this compendious effort encompasses different methods of synthesis and biological evaluation of heterocyclic compounds. The main purpose of this book is to share the recent advances and scope of Bioactive Heterocycles for the future avenues in the field. It has specifically been designed by keeping in mind the wide interests of individuals engaged in the design and synthesis of biologically active heterocyclic compounds as well as research scientists in academia and industry. The authors expect this book to be a standard reference in Universities and industrial libraries.
Publisher: Nova Science Publishers
ISBN: 9781622576364
Category : Bioactive compounds
Languages : en
Pages : 0
Book Description
This book is a critical and lucid account of various synthetic methodologies and biological activities of different sized bioactive heterocyclic compounds. In effect, this book imparts a great deal of comprehensive reviews about the chemistry and biology of selected groups of heterocycles and natural products including important pharmaceuticals as well as agrochemical pesticides in one handy project. Besides, this compendious effort encompasses different methods of synthesis and biological evaluation of heterocyclic compounds. The main purpose of this book is to share the recent advances and scope of Bioactive Heterocycles for the future avenues in the field. It has specifically been designed by keeping in mind the wide interests of individuals engaged in the design and synthesis of biologically active heterocyclic compounds as well as research scientists in academia and industry. The authors expect this book to be a standard reference in Universities and industrial libraries.