The Chromosomal Code PDF Download

Author: Lawrence Watt-Evans
Publisher: Avon Books
ISBN: 9780380872053
Category : Fiction
Languages : en
Pages : 204

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Author: Lawrence Watt-Evans
Publisher: Misenchanted Press
ISBN: 161991039X
Category : Fiction
Languages : en
Pages : 179

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A sudden inexplicable ice age has driven Earth's population into the tropics, except for a few die-hards eking out a tenuous existence scavenging the snow-covered ruins of civilization. One such straggler is John Starkman, making his home in the frozen wastes of western Pennsylvania. Already an outcast because of a certain physical peculiarity, he saw no reason to join his neighbors in fleeing south.

Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0

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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309038405
Category : Science
Languages : en
Pages : 128

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There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Author: M. Clark
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 364

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This text presents a concise account of modern cytogenetics. Basic facts are presented together with illustrative examples from plant, animal and medical cytogenetics. Selected references guide the reader to recent literature. New molecular cytogenetics techniques are reviewed.

Author: Adrian T. Sumner
Publisher: John Wiley & Sons
ISBN: 0470695226
Category : Science
Languages : en
Pages : 304

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Integrating classical knowledge of chromosome organisation with recent molecular and functional findings, this book presents an up-to-date view of chromosome organisation and function for advanced undergraduate students studying genetics. The organisation and behaviour of chromosomes is central to genetics and the equal segregation of genes and chromosomes into daughter cells at cell division is vital. This text aims to provide a clear and straightforward explanation of these complex processes. Following a brief historical introduction, the text covers the topics of cell cycle dynamics and DNA replication; mitosis and meiosis; the organisation of DNA into chromatin; the arrangement of chromosomes in interphase; euchromatin and heterochromatin; nucleolus organisers; centromeres and telomeres; lampbrush and polytene chromosomes; chromosomes and evolution; chromosomes and disease, and artificial chromosomes. Topics are illustrated with examples from a wide variety of organisms, including fungi, plants, invertebrates and vertebrates. This book will be valuable resource for plant, animal and human geneticists and cell biologists. Originally a zoologist, Adrian Sumner has spent over 25 years studying human and other mammalian chromosomes with the Medical Research Council (UK). One of the pioneers of chromosome banding, he has used electron microscopy and immunofluorescence to study chromosome organisation and function, and latterly has studied factors involved in chromosome separation at mitosis. Adrian is an Associate Editor of the journal Chromosome Research, acts as a consultant biologist and is also Chair of the Committee of the International Chromosome Conferences. The most up-to-date overview of chromosomes in all their forms. Introduces cutting-edge topics such as artificial chromosomes and studies of telomere biology. Describes the methods used to study chromosomes. The perfect complement to Turner.

Author: Jessica Wapner
Publisher: The Experiment, LLC
ISBN: 1615191658
Category : Health & Fitness
Languages : en
Pages : 345

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One of The Wall Street Journal’s 10 Best Nonfiction Books of the Year Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

Author: N.S. Sharma
Publisher: Mittal Publications
ISBN: 9788182930209
Category : Chromosomes
Languages : en
Pages : 304

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Author: Herman E. Wyandt
Publisher: Springer Science & Business Media
ISBN: 9400708963
Category : Medical
Languages : en
Pages : 216

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Human Chromosome Variation: Heteromorphism and Polymorphism was formerly printed under the title “Atlas of Human Chromosome Heteromorphism”. The Atlas has become a standard reference book in most cytogenetic laboratories and is cited as a significant reference in ISCN 2009. This revised version has updated and retained the most useful pictorial sections of the first edition, including the comprehensive review of normal and “not-so-normal” variations of the human karyotype with summaries and extensive reference lists organized by chromosome number. This updated edition features concise background information on chromosome methods and applications, essential information on heteromorphism frequencies in normal and clinical populations as well as new listing and discussions of euchromatic, subtelomeric and FISH variants. The addition of two new sections make this an even more valuable reference than before. A section on common and rare fragile sites includes a short historical discussion, definitions and an extensive table of officially recognized sites that includes the HUGO name, chromosomal location, methods of induction, genes and references to the most recent molecular characterization. A new section on array CGH discusses the clinical challenge of interpreting copy number variations (CNVs) revealed by this newest technology, gives examples of various levels of interpretation and lists the several most common websites used in this interpretation.

Author: M. Clark
Publisher: Springer
ISBN: 9789400900738
Category : Medical
Languages : en
Pages : 0

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to the expression of oncogenes, which are pivotal in cancer genetics. Accurate delineation and prognosis of a cancer may depend upon careful cytogenetic analysis. Cytogenetics is still of great importance when monitoring changes in somatic cell hybrids. The role of chromosome genetics within modern biology is continually changing and evolving, and thus a knowledge of cytogenetics is of ever-increasing value. Chromatin structure 1 and replication Summary It is now a well-known fact that DNA is the hereditary material and that the vast majority of the DNA of an organism is housed in organelles called chromo somes. However, the length of DNA contained in a cell is far greater than the size of the cell within which it exists; for example, the shortest human chromosome consists of 1. 4 cm of DNA which must be compacted into a cell only a few micrometres across. To achieve this, DNA has to undergo several levels of packing, a process that is a mixture of DNA-DNA and DNA protein interactions. The most compact form of DNA can be seen under the light microscope as a meta phase chromosome during mitotic cell division. DNA must also be faithfully replicated to ensure accurate cell function and maintenance of the organ ism as well as ultimately, the reproduction of the species. Our current knowledge of these complex processes is very limited, with huge gaps, in particular, concern ing the links between the molecular and organelle level of organization.