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Author: D. Neil Granger Publisher: Morgan & Claypool Publishers ISBN: 1615041656 Category : Medical Languages : en Pages : 99
Book Description
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Author: D. Neil Granger Publisher: Morgan & Claypool Publishers ISBN: 1615041656 Category : Medical Languages : en Pages : 99
Book Description
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Author: Urs Munzinger Publisher: Springer ISBN: 3642188168 Category : Medical Languages : en Pages : 312
Book Description
Primary knee arthroplasty (PKA) has a long history and modern mobile bearing knee implants are successfully implanted worldwide since 1977. Primary Knee Arthroplasty focuses on basic science, personal surgical experiences, clinical, functional and radiographic outcomes of PKA, with special focus on challenging knees such as severe varus and valgus deformities with associated bone defects, fixed flexion deformities, soft tissue contractures, and arthrodesed knees. Patella treatment with or without resurfacing is addressed in great detail. Early criterion-based rehabilitation and the patient’s return to participating in sports are discussed as is the management of prosthetic or surgery related complications. Lavishly illustrated to complement the text, Primary Knee Arthroplasty is a ‘must-have’ for all practicing knee replacement surgeons, orthopedic surgeons in training, orthopedic nurses, and physiotherapists with a special interest in knee arthroplasty. Tips and tricks provided by experienced knee surgeons are indispensable for daily clinical practice.
Author: Jaime Arias, Maria-Angeles Aller and Jose-Ignacio Arias Publisher: Bentham Science Publishers ISBN: 1608057852 Category : Medical Languages : en Pages : 361
Book Description
This monograph offers the reader an integrated point-of-view about the inflammatory response related to injury, infections and tumors. This integration is based on the hypothesis that the multiple pathophysiological mechanisms making up inflammation represent the re-expression of ontogenic mechanisms during early embryo development as well as the recapitulation of ancestral phylogenetic mechanisms. The relevance of the anti-inflammatory treatments is also highlighted with respect to polytraumatic patients, advances in stem cell research, embryology and the wound healing mechanism. Readers of this book will have the chance of gaining a unique perspective about of the pathophysiological mechanisms involved in the multiple inflammatory conditions. This integrative concept about inflammation can be applied in biological investigation, as well as in clinical research and translational medicine.
Author: Andrew Welsh Publisher: ISBN: 9781904752691 Category : Surgical wound infections Languages : en Pages : 142
Book Description
Infections that occur in the wound created by an invasive surgical procedure are generally referred to as surgical site infections (SSIs). SSIs are one of the most important causes of healthcare-associated infections (HCAIs). A prevalence survey undertaken in 2006 suggested that approximately 8% of patients in hospital in the UK have an HCAI. SSIs accounted for 14% of these infections and nearly 5% of patients who had undergone a surgical procedure were found to have developed an SSI. However, prevalence studies tend to underestimate SSI because many of these infections occur after the patient has been discharged from hospital. SSIs are associated with considerable morbidity and it has been reported that over one-third of postoperative deaths are related, at least in part, to SSI. However, it is important to recognise that SSIs can range from a relatively trivial wound discharge with no other complications to a life-threatening condition. Other clinical outcomes of SSIs include poor scars that are cosmetically unacceptable, such as those that are spreading, hypertrophic or keloid, persistent pain and itching, restriction of movement, particularly when over joints, and a significant impact on emotional wellbeing. SSI can double the length of time a patient stays in hospital and thereby increase the costs of health care. Additional costs attributable to SSI of between £814 and £6626 have been reported depending on the type of surgery and the severity of the infection. The main additional costs are related to re-operation, extra nursing care and interventions, and drug treatment costs. The indirect costs, due to loss of productivity, patient dissatisfaction and litigation, and reduced quality of life, have been studied less extensively.
Author: Robert Fitridge Publisher: University of Adelaide Press ISBN: 1922064009 Category : Medical Languages : en Pages : 589
Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: Gerard Doherty Publisher: McGraw Hill Professional ISBN: 0071635157 Category : Medical Languages : en Pages : 1328
Book Description
To-the-point information on more than 1000 diseases and disorders surgeons are most likely to encounter The leading single-source surgery book for house-staff, students, practitioners, and surgeons A Doody's Core Title for 2011! "This is an excellent source of updated, authoritative, and concise information on diseases encountered in general surgery and the surgical subspecialties of otolaryngology, urology, gynecology, orthopedics, plastic and reconstructive surgery, and pediatrics....This is a wonderful resource for all levels of surgical practitioners as well as nonsurgical practitioners. In my experience, it has provided me with a framework to prepare for both oral and written boards. 3 Stars."--Doody's Review Service Authoritative, concise, and completely up-to-date, CURRENT Diagnosis & Treatment Surgery features: Wide-ranging coverage that encompasses general surgery and all the important subspecialties including otolaryngology, urology, gynecology, orthopedics, plastic and reconstructive surgery, and pediatrics References linked to recent journal articles Logical quick-find organization made even more accessible by a comprehensive index More than 600 informative photographs and illustrations Detailed treatment algorithms NEW CD-ROM with content from Quick Answers: Surgery to speed diagnosis of symptoms and signs NEW Chapter on Training, Communication, Professionalism, and Systems-Based Practice Completely rewritten chapters on Wound Healing, Anesthesia, Otolaryngology/Head & Neck Surgery, The Heart, Neurosurgery, Gynecology, and Orthopedics
Author: Luis M. Rubio-Martinez Publisher: John Wiley & Sons ISBN: 1119190088 Category : Medical Languages : de Pages : 896
Book Description
Complications in Equine Surgery is the first reference to focus exclusively on understanding, preventing, recognizing, managing, and prognosing, technical and post-procedural complications in equine surgery. Edited by two noted experts on the topic, the book presents evidence-based information using a clear approach, organized by body system. Featuring color images, the book contains detailed coverage of the gastrointestinal, respiratory, musculoskeletal, urogenital, and neurological systems. Each chapter contains a short introduction of the procedure with explanations of when and how the procedure is to be performed. All chapters review how to recognize and prevent technical complications and explain how to manage post-operative complications. This important text: Offers the first resource specifically focused on complications encountered in equine surgery Takes a helpful format organized by body system Provides consistently formatted chapters for ease of use Covers clinically relevant information for dealing with technical and post-operative complications Presents more than 350 color images to illustrate the concepts described Written for general practitioners and specialists, Complications in Equine Surgery is an essential resource to decreasing morbidity and mortality and increasing surgical success in horses.
Author: Bo Shen Publisher: Academic Press ISBN: 0128113898 Category : Medical Languages : en Pages : 382
Book Description
Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers. - Incorporates state-of-the-art of research in the area of therapeutic endoscopy in Crohn's Disease and Ulcerative Colitis - Makes the connection between the understanding of the complex nature and disease course of IBD with corresponding advanced endoscopic procedures - Explores endoscopic treatment as the missing link between medical and surgical treatment for complex Crohn's Disease and Ulcerative Colitis - Contains access to videos demonstrating important procedural concepts
Author: World Health Organization Publisher: ISBN: 9789241549882 Category : Medical Languages : en Pages : 184
Book Description
Surgical site infections are caused by bacteria that get in through incisions made during surgery. They threaten the lives of millions of patients each year and contribute to the spread of antibiotic resistance. In low- and middle-income countries, 11% of patients who undergo surgery are infected in the process. In Africa, up to 20% of women who have a caesarean section contract a wound infection, compromising their own health and their ability to care for their babies. But surgical site infections are not just a problem for poor countries. In the United States, they contribute to patients spending more than 400 000 extra days in hospital at a cost of an additional US $10 billion per year. No international evidence-based guidelines had previously been available before WHO launched its global guidelines on the prevention of surgical site infection on 3 November 2016, and there are inconsistencies in the interpretation of evidence and recommendations in existing national guidelines. These new WHO guidelines are valid for any country and suitable to local adaptations, and take account of the strength of available scientific evidence, the cost and resource implications, and patient values and preferences.
Author: D. Neil Granger
Author: D. Neil Granger
Author: Urs Munzinger
Author: Jaime Arias, Maria-Angeles Aller and Jose-Ignacio Arias
Author: Andrew Welsh
Author: Robert Fitridge
Author: Gerard Doherty
Author: René Holzheimer
Author: Luis M. Rubio-Martinez
Author: Bo Shen
Author: World Health Organization