Superparamagnetic Iron Oxide Nanoparticles Development, Characterization, Cupper-64 Labeling and Cellular Tracking PDF Download

Author: Nazanin Hoshyar Masoodzadehgan
Publisher:
ISBN:
Category : Diagnostic imaging
Languages : en
Pages :

View

Book Description

Author: Suelin Chen (Ph.D.)
Publisher:
ISBN:
Category :
Languages : en
Pages : 158

View

Book Description
One of the most versatile and safe materials used in medicine are polymer-coated iron oxide nanoparticles. This dissertation describes several formulations for in vivo imaging applications. The paramagnetic polymer-coated iron oxide nanoparticle aminoSPARK is used as a fluorescence-mediated tomography (FMT) imaging agent for stratification of prostate cancer tumors. This is achieved by conjugating it to a peptide that targets SPARC (secreted protein acidic rich in cysteine), a biomarker protein associated with aggressive forms of prostate cancer. Several types of polymer coatings for iron oxide nanoparticles have been systematically explored using a novel high-throughput screening technique to optimize coating chemistries and synthetic conditions to produce nanoparticles with maximum stability and ability to lower T2 contrast for MR imaging (R2, or relaxivity). Carboxymethyl dextran emerged from the screen as an ideal coating for superparamagnetic iron oxide nanoparticles. A commercially available, FDA-approved nanoparticle with similar surface chemistry, Feraheme, was chosen as a platform nanoparticle for further development. This work presents the first instance of chemical modification of Feraheme, making it more amenable to bioconjugation by converting its free carboxyl groups to free amine groups. This amine-functionalized Feraheme nanoparticle (amino-FH) is then used as a base nanoparticle to which various targeting and reporting functionalities can be added. A FH-based nanoparticle that can be used for cell loading is synthesized by covalently combining Feraheme with protamine, a pharmaceutical that also acts as a membrane translocating agent. A rhodamine-protamine conjugate is synthesized and then covalently bound to amino-FH using carbodiimide (CDI) chemistry. This results in a magnetofluorescent cell-labeling nanoparticle (ProRho-FH) that is readily taken up by mouse mesenchymal stem cells and U87 glioma cells. ProRho-FH can be used to non-invasively track cells for development and monitoring of cell-based therapies or for further investigation of biological mechanisms such as cell migration, tumor growth, and metastasis. This combination of two FDA-approved, commercially available materials to yield a superparamagnetic and fluorescent cell labeling nanoparticle is an excellent alternative to the recently discontinued Feridex. All polymer-coated iron oxide nanoparticles used in this dissertation were thoroughly characterized to fully understand their physicochemical and magnetic properties.

Author: David C. Hess
Publisher: Springer
ISBN: 3319150634
Category : Science
Languages : en
Pages : 371

View

Book Description
Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the "big pharma" perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.

Author: J. Ping Liu
Publisher: Springer Science & Business Media
ISBN: 0387856005
Category : Science
Languages : en
Pages : 731

View

Book Description
Nanoscale Magnetic Materials and Applications covers exciting new developments in the field of advanced magnetic materials. Readers will find valuable reviews of the current experimental and theoretical work on novel magnetic structures, nanocomposite magnets, spintronic materials, domain structure and domain-wall motion, in addition to nanoparticles and patterned magnetic recording media. Cutting-edge applications in the field are described by leading experts from academic and industrial communities. These include new devices based on domain wall motion, magnetic sensors derived from both giant and tunneling magnetoresistance, thin film devices in micro-electromechanical systems, and nanoparticle applications in biomedicine. In addition to providing an introduction to the advances in magnetic materials and applications at the nanoscale, this volume also presents emerging materials and phenomena, such as magnetocaloric and ferromagnetic shape memory materials, which motivate future development in this exciting field. Nanoscale Magnetic Materials and Applications also features a foreword written by Peter Grünberg, recipient of the 2007 Nobel Prize in Physics.

Author: Vinod Kumar Yata
Publisher: Springer Nature
ISBN: 3030471209
Category : Technology & Engineering
Languages : en
Pages : 340

View

Book Description
This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Author: Sophie Laurent
Publisher: Elsevier
ISBN: 9780081019252
Category : Technology & Engineering
Languages : en
Pages : 0

View

Book Description
Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine.

Author: Anton Ficai
Publisher: Elsevier
ISBN: 0323461514
Category : Science
Languages : en
Pages : 724

View

Book Description
Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. - Shows how nanoantibiotics can be used to more effectively treat disease - Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs - Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area

Author: Brian M. Dale
Publisher: John Wiley & Sons
ISBN: 1119013038
Category : Medical
Languages : en
Pages : 246

View

Book Description
This fifth edition of the most accessible introduction to MRI principles and applications from renowned teachers in the field provides an understandable yet comprehensive update. Accessible introductory guide from renowned teachers in the field Provides a concise yet thorough introduction for MRI focusing on fundamental physics, pulse sequences, and clinical applications without presenting advanced math Takes a practical approach, including up-to-date protocols, and supports technical concepts with thorough explanations and illustrations Highlights sections that are directly relevant to radiology board exams Presents new information on the latest scan techniques and applications including 3 Tesla whole body scanners, safety issues, and the nephrotoxic effects of gadolinium-based contrast media

Author: Roderick A. Slavcev
Publisher: Springer
ISBN: 3319782592
Category : Science
Languages : en
Pages : 129

View

Book Description
This work was compiled to serve as a convenient source that covers a number of techniques (and details of their use) in the rather large field of nanomedicine, with special attention paid to gene delivery. As principal investigators working in the field of nanomedicine, we sought to put together the most current and relevant topics in gene delivery, imaging and evaluation systems. We expect the work to serve very well for scientists and graduate students in the nanomedicine field.

Author: Beth A. Goins
Publisher: CRC Press
ISBN: 9814267090
Category : Science
Languages : en
Pages : 308

View

Book Description
The first resource of its kind, this book covers cutting-edge research on the use of nanoparticles for in vivo diagnostic medical imaging and therapy. It discusses a variety of nanoparticles, including quantum dots, carbon nanotubes, dendrimers, gold nanoshells, metal nanorods, micelles, liposomes, polymers, MRI iron oxide particles, and microbubbles. Examples in the book include multifunctional nanoparticles that designed for multimodality imaging and simultaneous diagnostic and therapy (theranostic) applications.