Studies of Bio-active Molecules by Matrix Assisted Laser Desorption/ionization and Electrospray Ionization Mass Spectrometry PDF Download

Author: Ying Cheng
Publisher:
ISBN:
Category : Biomolecules
Languages : en
Pages : 172

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Author: Mingfeng Bai
Publisher:
ISBN:
Category : Biomolecules
Languages : en
Pages : 138

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Author: Ivory Xingyu Peng
Publisher:
ISBN:
Category :
Languages : en
Pages : 314

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Book Description

Author: Rainer Cramer
Publisher: Springer
ISBN: 9783319358017
Category : Science
Languages : en
Pages : 286

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Book Description
This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI (electrospray ionization) • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics

Author: Yongdong Zhu
Publisher:
ISBN:
Category :
Languages : en
Pages : 364

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Author: Moon-Ju Kim
Publisher: Springer Nature
ISBN: 981996878X
Category : Science
Languages : en
Pages : 107

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Book Description
This book presents innovative laser desorption ionization (LDI)-active nanophotonic structures for addressing the challenges that matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) is currently facing and for enhancing LDI efficiency. It presents a variety of cutting-edge nanophotonic structures to satisfy the mass-analytical needs of sensitivity, reproducibility, and quantification. As opposed to the commercialized, conventional organic matrix used in MALDI-MS, these nanostructures are validated to be highly effective in detecting small metabolites and drugs, highlighting their considerable potential in the mass spectrometry field. It also systematically elucidates fundamental LDI processes in terms of the photo-thermal, electronic, and structural characteristics of nanophotonic structures, offering mechanistic knowledge of LDI-MS. Even though LDI-MS performance is heavily influenced by a number of nanostructure parameters, relatively little is known about the LDI processes associated with those characteristics. An in-depth understanding of nanostructure characteristics and LDI mechanisms thus paves the way for more effective, rational design and development of nanostructures with improved LDI capabilities. Further, with a focus on multiple cascades in nanostructure functions in response to laser pulse stimuli, this book provides detailed, step-by-step procedures to design and construct a nanophotonic, LDI-active platform, which may serve as a roadmap for graduate students in the field of mass spectrometry. Readers, including graduate students, researchers, and experts working in the related areas of mass spectrometry, nanophotonics, and material science and material engineering, will find a wealth of useful information in this book.

Author: Pao-Chi Liao
Publisher:
ISBN:
Category : Mass spectrometry
Languages : en
Pages : 354

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Author: Yan-Hui Liu
Publisher:
ISBN:
Category :
Languages : en
Pages : 460

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Author: Joseph Banoub
Publisher: Springer
ISBN: 9401792380
Category : Science
Languages : en
Pages : 290

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Book Description
This NATO-ASI installment is designed to provide an advanced overview for doctoral and post-doctoral candidates of the state-of-the-art technologies for bio-detection. The main objective of the work aims at providing readers with the latest developments necessary to successfully understand the CBRN Agents and their associated biotechnologies. The core methods focused on are mass spectrometry (including chromatographic and electrophoretic separation) and comparisons to spectroscopic, immunological and molecular analysis of chemical, biological and nuclear agents.

Author: Alison E Ashcroft
Publisher: Royal Society of Chemistry
ISBN: 184755119X
Category : Science
Languages : en
Pages : 188

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Book Description
Ionization Methods in Organic Mass Spectrometry is a basic practical guide for scientists of all disciplines who wish to analyse samples by organic mass spectrometry. Concentrating on instrumental operation, this book gives step-by-step instructions on how to set up, and how to achieve the best results, using a range of ionization methods, including atmospheric pressure chemical ionization, electrospray ionization and matrix assisted laser desorption ionization. Ionization Methods in Organic Mass Spectrometry will enable a beginner, or practitioner with limited experience, to choose the most appropriate ionization technique in application areas such as biomolecules, drugs and metabolites, pesticides, polymers and many other organic compounds. It will be a valuable practical guide for technicians, graduates, students or researchers - or indeed anyone new to practical organic mass spectrometry.