Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels PDF Download
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Author: Publisher: Academic Press ISBN: 0128026316 Category : Science Languages : en Pages : 379
Book Description
This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field. - Presents a comprehensive overview of the latest research into GIRK potassium channels - Serves as a perfect starting point for researchers and practitioners entering the field - Expands the literature and field of neurobiology
Author: Publisher: Academic Press ISBN: 0128026316 Category : Science Languages : en Pages : 379
Book Description
This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field. - Presents a comprehensive overview of the latest research into GIRK potassium channels - Serves as a perfect starting point for researchers and practitioners entering the field - Expands the literature and field of neurobiology
Author: Publisher: Academic Press ISBN: 0128029544 Category : Science Languages : en Pages : 243
Book Description
RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. - Brings together information on the current state of the RGS protein field - Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking - Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery
Author: Enrico Cherubini Publisher: Frontiers Media SA ISBN: 2889196313 Category : Hippocampus (Brain) Languages : en Pages : 167
Book Description
The CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low probability of release and pronounced frequency-dependent facilitation. In addition MF terminals are endowed with mGluRs that regulate their own release. We will describe the intrinsic membrane properties of pyramidal cells, which can sometimes fire in bursts, together with the geometry of their dendritic arborization. The single layer of pyramidal cells is quite distinct from the six-layered neocortical arrangement. The resulting aligned dendrites provides the substrate for laminated excitatory inputs. They also underlie a precise, diversity of inhibitory control which we will also describe in detail. The CA3 region has an especially rich internal connectivity, with recurrent excitatory and inhibitory loops. In recent years both in vivo and in vitro studies have allowed to better understand functional properties of the CA3 auto-associative network and its role in information processing. This circuit is implicated in encoding spatial representations and episodic memories. It generates physiological population synchronies, including gamma, theta and sharp-waves that are presumed to associate firing in selected assemblies of cells in different behavioral conditions. The CA3 region is susceptible to neurodegeneration during aging and after stresses such as infection or injury. Loss of some CA3 neurones has striking effects on mossy fiber inputs and can facilitate the generation of pathologic synchrony within the CA3 micro-circuit. The aim of this special topic is to bring together experts on the cellular and molecular mechanisms regulating the wiring properties of the CA3 hippocampal microcircuit in both physiological and pathological conditions, synaptic plasticity, behavior and cognition.We will particularly emphasize the dual glutamatergic and GABAergic phenotype of MF-CA3 synapses at early developmental stages and the steps that regulate the integration of newly generated neurons into the adult dentate gyrus-CA3 circuit.
Author: Duane E. Haines Publisher: Elsevier Health Sciences ISBN: 145573327X Category : Medical Languages : en Pages : 504
Book Description
Turn to Fundamental Neuroscience for a thorough, clinically relevant understanding of this complicated subject! Integrated coverage of neuroanatomy, physiology, and pharmacology, with a particular emphasis on systems neurobiology, effectively prepares you for your courses, exams, and beyond. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Easily comprehend and retain complex material thanks to the expert instruction of Professor Duane Haines, recipient of the Henry Gray/Elsevier Distinguished Teacher Award from the American Association of Anatomists and the Distinguished Teacher Award from the Association of American Colleges. Your purchase of this book entitles you to access www.studentconsult.com at no extra charge. This innovative web site offers you an interactive center with a wealth of additional resources. Grasp important anatomical concepts and their clinical applications thanks to correlated state-of-the-art imaging examples, anatomical diagrams, and histology photos. Retain key information and efficiently study for your exams with clinical highlights integrated and emphasized within the text.
Author: Per Hellman Publisher: Springer Science & Business Media ISBN: 1493905090 Category : Medical Languages : en Pages : 242
Book Description
Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene – KCNJ5 – in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.
Author: David W. Marshak Publisher: Frontiers Media SA ISBN: 2832553516 Category : Medical Languages : en Pages : 261
Book Description
This is a remarkable time to study the vertebrate retina, either as a model for the brain or to understand the first steps in vison. We have known about the diversity of retinal neurons and glia for more than one hundred years, and we are now extending these findings and making new discoveries about retinal cell types by analyzing gene expression in single cells. We have made significant progress toward our ultimate goals of describing the neural circuits in the retinas at the level of connections between identified populations of neurons and understanding neuronal and glial cell function at the molecular level. We have also made great strides toward understanding retinal development and the etiology of retinal diseases. Physiologists are now using more realistic stimuli and modern analytical methods to analyze the mechanisms underlying light responses of retinal neurons, and this has led to more accurate computational models of neural circuits in the retina. My colleague at the McGovern Medical School in Houston, Steve Massey, has made many important contributions to this field, both as a researcher and as a mentor, and he is planning his retirement. Judith Ogilvie, Christophe Ribelayga, Chai-an Mao and I will dedicate this issue to him and plan to publish some of his latest work. This Research Topic will include mini-reviews and brief communications about neurons and neural circuits in vertebrate retinas. The scope will be very broad, including anatomical, physiological, psychophysical and computational approaches to this topic. Potential topics include, but are not restricted to: • Development. morphology and synaptic connections of neuronal types • Light responses, spontaneous activity and membrane properties of retinal neurons • Gene expression and other aspects of cell biology of identified retinal neurons • Release of neurotransmitters and modulators and their effects in the retina • Structure and function of electrical synapses in the retina • Neural circuits that mediate responses to color, contrast and movement • Roles of neuroglia in retinal development, homeostasis and light responses • Contributions of neural circuits in the retina to visual perception • Evolution of neuronal types and neural circuits in the retina • Novel techniques for analyzing retinal neurons and neural circuits • Non-invasive methods to analyze retinal structure and function • Etiology of retinal diseases and potential new therapies • Directions for future research on the vertebrate retina
Author: Angelika Böttger Publisher: Springer ISBN: 3319995464 Category : Medical Languages : en Pages : 222
Book Description
This textbook provides a structured, easy to understand and thorough insight into the mode of function of plant secondary metabolites in plants and humans. It explains the biosynthesis and molecular action of nicotine, cannabis, caffeine and Co, describes the effects of these drugs on signal transduction at receptors and ion channels in animals, their relevance for human health and their potential for recreational use and abuse. It also offers a broad and comprehensive understanding on the role and function of these diverse molecules for the plants that make them. This textbook is written for master students and scientist in biochemistry and biology as well as for pharmaceutical and medical students. It will be a valuable study tool for teachers and students alike.
Author: Jie Zheng Publisher: CRC Press ISBN: 1466551429 Category : Medical Languages : en Pages : 682
Book Description
The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Author: Publisher: Academic Press ISBN: 0080585175 Category : Medical Languages : en Pages : 522
Book Description
This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins. Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal hypertension. Written by leading scientists in the field, this volume offers readers a comprehensive update of this field in the understanding of the genes, molecular structure, function and diseases of potassium ion channels.Key Features* The first comprehensive volume on potassium ion channels in all aspects of genes, molecular structure, function, and diseases* Completely up-to-date information* Written by leading scientists in the field
Author: Michel Félétou Publisher: Morgan & Claypool Publishers ISBN: 1615041230 Category : Science Languages : en Pages : 309
Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
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Author: Enrico Cherubini
Author: Duane E. Haines
Author: Per Hellman
Author: David W. Marshak
Author: Angelika Böttger
Author: Jie Zheng
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Author: Michel Félétou