Structural Matching Algorithms in Molecular Biology PDF Download

Author: Daniel Fischer
Publisher:
ISBN:
Category :
Languages : en
Pages : 143

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Book Description

Author: Bruce R. Donald
Publisher: MIT Press
ISBN: 0262548798
Category : Science
Languages : en
Pages : 497

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Book Description
An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins.Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.

Author: Moshe Lewenstein
Publisher: Springer
ISBN: 3540354611
Category : Computers
Languages : en
Pages : 425

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Book Description
This book constitutes the refereed proceedings of the 17th Annual Symposium on Combinatorial Pattern Matching, CPM 2006, held in Barcelona, Spain, July 2006. The book presents 33 revised full papers together with 3 invited talks, organized in topical sections on data structures, indexing data structures, probabilistic and algebraic techniques, applications in molecular biology, string matching, data compression, and dynamic programming.

Author: Mourad Elloumi
Publisher: John Wiley & Sons
ISBN: 1118101987
Category : Science
Languages : en
Pages : 1027

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Book Description
This book represents the most comprehensive and up-to-date collection of information on the topic of computational molecular biology. Bringing the most recent research into the forefront of discussion, Algorithms in Computational Molecular Biology studies the most important and useful algorithms currently being used in the field, and provides related problems. It also succeeds where other titles have failed, in offering a wide range of information from the introductory fundamentals right up to the latest, most advanced levels of study.

Author: Carsten Helgesen
Publisher:
ISBN:
Category :
Languages : en
Pages : 132

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Author: Nurit Haspel
Publisher: Springer Nature
ISBN: 303105914X
Category : Science
Languages : en
Pages : 120

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Book Description
The three-dimensional structure and function of molecules present many challenges and opportunities for developing an understanding of biological systems. With the increasing availability of molecular structures and the advancing accuracy of structure predictions and molecular simulations, the space for algorithmic advancement on many analytical and predictive problems is both broad and deep. To support this field, a rich set of methods and algorithms are available, addressing a variety of important problems such as protein-protein interactions, the effect of mutations on protein structure and function, and protein structure determination. Despite recent advancements in the field, in particular in protein folding with the development of AlphaFold, many problems still remain unsolved. In this book we focus on a number of topics in Structural Bioinformatics: Cryo-EM structural detection, protein conformational exploration, elucidation of molecular binding surface using geometry, the effect of mutations, insertions and deletions on protein structural stability, and protein-ligand binding.

Author: Gabriel Valiente
Publisher: CRC Press
ISBN: 1420069748
Category : Computers
Languages : en
Pages : 370

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Book Description
Emphasizing the search for patterns within and between biological sequences, trees, and graphs, Combinatorial Pattern Matching Algorithms in Computational Biology Using Perl and R shows how combinatorial pattern matching algorithms can solve computational biology problems that arise in the analysis of genomic, transcriptomic, proteomic, metabolomic

Author: Philippe Jacquet
Publisher: Cambridge University Press
ISBN: 1316298043
Category : Computers
Languages : en
Pages : 389

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Book Description
How do you distinguish a cat from a dog by their DNA? Did Shakespeare really write all of his plays? Pattern matching techniques can offer answers to these questions and to many others, from molecular biology, to telecommunications, to classifying Twitter content. This book for researchers and graduate students demonstrates the probabilistic approach to pattern matching, which predicts the performance of pattern matching algorithms with very high precision using analytic combinatorics and analytic information theory. Part I compiles known results of pattern matching problems via analytic methods. Part II focuses on applications to various data structures on words, such as digital trees, suffix trees, string complexity and string-based data compression. The authors use results and techniques from Part I and also introduce new methodology such as the Mellin transform and analytic depoissonization. More than 100 end-of-chapter problems help the reader to make the link between theory and practice.

Author: Dan Hirschberg
Publisher: Springer Science & Business Media
ISBN: 9783540612582
Category : Computers
Languages : en
Pages : 408

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Book Description
This book constitutes the refereed proceedings of the 7th Annual Symposium on Combinatorial Pattern Matching, CPM '96, held in Laguna Beach, California, USA, in June 1996. The 26 revised full papers included were selected from a total of 48 submissions; also included are two invited papers. Combinatorial pattern matching has become a full-fledged area of algorithmics with important applications in recent years. The book addresses all relevant aspects of combinatorial pattern matching and its importance in information retrieval, pattern recognition, compiling, data compression, program analysis, and molecular biology and thus describes the state of the art in the area.

Author: Alberto Apostolico
Publisher: Springer Science & Business Media
ISBN: 9783540632207
Category : Computers
Languages : en
Pages : 292

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Book Description
This book constitutes the refereed proceedings of the Eighth Annual Symposium on Combinatorial Pattern Matching, CPM 97, held in Aarhus, Denmark, in June/July 1997. The volume presents 20 revised full papers carefully selected from 32 submissions received; also included are abstracts of two invited contributions. The volume is devoted to the issue of searching and matching strings and more complicated patterns, such as trees, regular expressions, graphs, point sets and arrays. The results presented are particularly relevant to molecular biology, but also to information retrieval, pattern recognition, compiling, data compression and program analysis.