Striatal Signaling: Two Decades of Progress PDF Download

Author: Emmanuel Valjent
Publisher: Frontiers E-books
ISBN: 2889190706
Category :
Languages : en
Pages : 216

View

Book Description
This Research Topic aims to highlight and cover recent understanding on striatal signaling pathways, which are activated by a variety of therapeutic agents or drugs of abuse in physiological and pathological context. The recent development of different mouse models allowing the identification of specific cell types and neuronal circuits in which a given signaling pathway is activated in various physiological and pathological conditions provides essential information and allowed to untangle the complexity of study signal transduction in the brain in vivo.

Author: Gong-Ping Liu
Publisher: Frontiers Media SA
ISBN: 2889744841
Category : Science
Languages : en
Pages : 147

View

Book Description

Author: Naomi A. Fineberg
Publisher: Springer Nature
ISBN: 303075393X
Category : Medical
Languages : en
Pages : 477

View

Book Description
The book highlights important new research approaches of clinical relevance, written by prominent researchers in the field of OCD and related disorders. A broad range of topics is covered, beginning with a description of the phenotypic features of the OCD followed by chapters on developmental aspects, animal models, genetic and biological models including neuro-inflammation, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered including clinical and pharmacogenetic treatment models. In this way the volume brings together the key disciplines involved in the neurobiological understanding of OCD to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators and clinicians interested in the present state of OCD research.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309069882
Category : Social Science
Languages : en
Pages : 610

View

Book Description
How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Author: Jerry J. Buccafusco
Publisher: CRC Press
ISBN: 1420041819
Category : Medical
Languages : en
Pages : 341

View

Book Description
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Author: Ahmed A. Moustafa
Publisher: Frontiers Media SA
ISBN: 2889193888
Category : Basal ganglia
Languages : en
Pages : 495

View

Book Description
The basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders. Most of this research—in both animals and humans—attempt to understand the neural and biochemical substrates of basic motor and learning processes, and how these are affected in human patients as well as animal models of brain disorders. The current volume contains research articles and reviews describing basic, pre-clinical and clinical neuroscience research of the basal ganglia written by attendees of the 11th Triennial Meeting of the International Basal Ganglia Society (IBAGS) that was held March 3-7th, 2013 at the Princess Hotel, Eilat, Israel and by researchers of the basal ganglia. Specifically, articles in this volume include research reports on the biochemistry, computational theory, anatomy and physiology of single neurons and functional circuitry of the basal ganglia networks as well as the latest data on animal models of basal ganglia dysfunction and clinical studies in human patients.

Author: Akhlaq A. Farooqui
Publisher: Springer Science & Business Media
ISBN: 0387730230
Category : Medical
Languages : en
Pages : 299

View

Book Description
Leading researchers offer cutting-edge information on glutamate metabolism in the brain, examining the role of glutamate transporters and the involvement of glutamate receptors in the pathogenesis of acute neural trauma and neurodegenerative diseases. In addition, the authors discuss the treatment of these diseases with endogenous and exogenous antioxidants and glutamate receptor antagonists.

Author: Heinz Steiner
Publisher: Academic Press
ISBN: 0128025263
Category : Medical
Languages : en
Pages : 1038

View

Book Description
Handbook of Basal Ganglia Structure and Function, Second Edition, offers an integrated overview of the structural and functional aspects of the basal ganglia, highlighting clinical relevance. The basal ganglia, a group of forebrain nuclei interconnected with the cerebral cortex, thalamus, and brainstem, are involved in numerous brain functions, such as motor control and learning, sensorimotor integration, reward, and cognition. These nuclei are essential for normal brain function and behavior, and their importance is further emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. This updated edition has been thoroughly revised to provide the most up-to-date account of this critical brain structure. Edited and authored by internationally acclaimed basal ganglia researchers, the new edition contains ten entirely new chapters that offer expanded coverage of anatomy and physiology, detailed accounts of recent advances in cellular/molecular mechanisms and cellular/physiological mechanisms, and critical, deeper insights into the behavioral and clinical aspects of basal ganglia function and dysfunction. Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cellular/molecular and cellular/physiological mechanisms, and behavioral and clinical aspects of function and dysfunction Written by international authors who are preeminent researchers in the field Explores, in full, the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases

Author: Greg Stuart
Publisher: Oxford University Press, USA
ISBN: 0198566565
Category : Medical
Languages : en
Pages : 578

View

Book Description
Dendrites form the major receiving part of neurons. This text presents a survey of knowledge on dendrites, from their morphology and development, through to their electrical chemical, and computational properties.

Author: Jonas H. Ellenberg
Publisher: CRC Press
ISBN: 9780824788230
Category : Medical
Languages : en
Pages : 600

View

Book Description
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.