Statistical Analysis of Matrix-assisted Laser Desorption/ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Data with Applications to Cancer Biomarker Detection PDF Download

Author: Donald Anthony Barkauskas
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 9

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The recent development of matrix-assisted UV laser desorption (LD) mass spectrometry has made possible the ionization and detection of extremely large molecules (with molecular weights exceeding 100,000 Daltons). This technique has generated enormous interest in the biological community for the direct examination of large peptides and oligonucleotides. Although this matrix-assisted ionization method has been developed and used almost exclusively with time-of-flight (TOF) mass spectrometers, research is currently in progress to demonstrate this technique with trapped ion mass spectrometers, such as Fourier transform ion cyclotron resonance mass spectrometry (FTMS). The potential capabilities of FTMS for wide mass range, high resolution measurement, and ion trapping experiments suggest that this instrumental technique should be useful for the detailed structural characterization of large ions generated by the matrix-assisted technique. We have recently demonstrated that matrix-assisted ultraviolet laser desorption can be successfully used with FTMS for the ionization of small peptides. The objective of this report is to summarize the application and current limitations of matrix-assisted laser desorption FTMS for the characterization of peptides and oligonucleotides at the isomeric level. 4 refs., 3 figs., 2 tabs.

Author: Dominique Heymann
Publisher: Academic Press
ISBN: 0080953883
Category : Medical
Languages : en
Pages : 501

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The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Author: Mehmed Kantardzic
Publisher: Wiley-IEEE Press
ISBN:
Category : Computers
Languages : en
Pages : 704

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Discover the next generation of data-mining tools and technology This book brings together an international team of eighty experts to present readers with the next generation of data-mining applications. Unlike other publications that take a strictly academic and theoretical approach, this book features authors who have successfully developed data-mining solutions for a variety of customer types. Presenting their state-of-the-art methodologies and techniques, the authors show readers how they can analyze enormous quantities of data and make new discoveries by connecting key pieces of data that may be spread across several different databases and file servers. The latest data-mining techniques that will revolutionize research across a wide variety of fields including business, science, healthcare, and industry are all presented. Organized by application, the twenty-five chapters cover applications in: Industry and business Science and engineering Bioinformatics and biotechnology Medicine and pharmaceuticals Web and text-mining Security New trends in data-mining technology And much more . . . Readers from a variety of disciplines will learn how the next generation of data-mining applications can radically enhance their ability to analyze data and open the doors to new opportunities. Readers will discover: New data-mining tools to automate the evaluation and qualification of sales opportunities The latest tools needed for gene mapping and proteomic data analysis Sophisticated techniques that can be engaged in crime fighting and prevention With its coverage of the most advanced applications, Next Generation of Data-Mining Applications is essential reading for all researchers working in data mining or who are tasked with making sense of an ever-growing quantity of data. The publication also serves as an excellent textbook for upper-level undergraduate and graduate courses in computer science, information management, and statistics.

Author: Xiaodong Wang
Publisher: Frontiers Media SA
ISBN: 2832534031
Category : Science
Languages : en
Pages : 114

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Author:
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ISBN:
Category : Medicine
Languages : en
Pages : 1892

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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Author: S. Mariccor Andresa Banluta Batoy
Publisher:
ISBN:
Category : Fourier transform spectroscopy
Languages : en
Pages : 314

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Author: Touradj Solouki
Publisher:
ISBN:
Category :
Languages : en
Pages : 362

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Author: Rainer Cramer
Publisher: Springer
ISBN: 3319048198
Category : Science
Languages : en
Pages : 287

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This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI (electrospray ionization) • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics

Author: John Anthony Castoro
Publisher:
ISBN:
Category : Electron-stimulated desorption
Languages : en
Pages : 492

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