Spectroscopic and Theroretical Definition of Binuclear Non-heme Iron Active Sites PDF Download

Author: Yi-Shan Yang
Publisher:
ISBN:
Category :
Languages : en
Pages : 558

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Author: Jennifer Kathleen Schwartz
Publisher:
ISBN:
Category :
Languages : en
Pages : 568

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Author: Kristoffer Andersson
Publisher: Nova Publishers
ISBN: 9781604561999
Category : Science
Languages : en
Pages : 236

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Book Description
The subject of this book is the amazing enzyme ribonucleotide reductase (RNR), the enzyme responsible for the conversion of ribonucleotides to deoxyribonucleotides. The prerequisite for DNA-synthesis and DNA-repair in all living cells is the supply of the four deoxyribonucleotides. Such molecules result from the enzymatically difficult radical-induced reduction of ribonucleotides, a multistep chemical process catalyzed by RNR. RNR was the first enzyme in which the presence of an amino acid radical (a tyrosyl) in E. coli Class Ia RNR has been proven; since then several other biological amino acid radical species have been found on e.g. tryptophan, glycine, cysteine, lysine residues and on amino acid derived small cofactors like 2 tryptophanes in thryptophan-trypthanyl-radical or cysteine-tyrosyl-radical in other enzymes. As all known cellular life forms store their genetic information as DNA, RNR is likely to be found in all growing cells of every living organism, a fact that is confirmed by a rapidly increasing number of genomic screenings.

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 2520

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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Author: Bernhard Grimm
Publisher: Springer Science & Business Media
ISBN: 1402045166
Category : Science
Languages : en
Pages : 603

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The first dedicated new work since 1991, this book reviews recent progress and current studies in the chemistry, metabolism and spectroscopy of chlorophylls, bacteriochlorophylls and their protein complexes. Also discussed is progress on the applications of chlorophylls as photosensitizers in photodynamic therapy of cancerous tumours, and as molecular probes in biochemistry, medicine, plant physiology, ecology and geochemistry. Each section offers an introductory overview followed by concise, focused and fully-referenced chapters written by experts.

Author: L. I. Simándi
Publisher: Elsevier Publishing Company
ISBN:
Category : Science
Languages : en
Pages : 748

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Dioxygen activation is a rapidly developing field in which research is directed at (1) modelling of biological oxidations, (2) design and utilization of new catalysts for oxidative transformations of organic substrates, (3) application of O 2 (and H 2 O 2 ) as a cheap oxidant in the manufacture of fine and bulk chemicals. Provided here is a collection of both review and original papers covering all aspects of dioxygen activation. All papers provide background information of previous work. Reactions mechanisms are extensively treated and a keyword index facilitates quick orientation. The book should prove invaluable to organic, bioinorganic and coordination chemists as well as biochemists interested in homogeneous catalysis.

Author: Edward I. Solomon
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 488

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Book Description
This volume contains recent advances in spectrographic methods, including EPR, magnetic Mossbauer, paramagnetic and multi-D NMR, metalloprotein crystallography, EAS, magnetic circular dichroism, resonance Raman, X-ray absorption spectroscopy, and electron structure calculations. The book concentrates on topics where spectrographic methods have had a major impact, such as electron transfer, cluster interactions, intermediates, and definition of active site structure, and it includes a thorough tutorial on basic methods.

Author: Bunshi Kagaku Kenkyūjo
Publisher:
ISBN:
Category : Chemical bonds
Languages : en
Pages : 618

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Author: American Chemical Society. Committee on Professional Training
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 1932

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Book Description
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.

Author: Christopher J Schofield
Publisher: Royal Society of Chemistry
ISBN: 1849739501
Category : Science
Languages : en
Pages : 508

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Book Description
Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.