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Author: Kenji Sugibayashi Publisher: Springer ISBN: 4431565264 Category : Medical Languages : en Pages : 410
Book Description
This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations. This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.
Author: Kenji Sugibayashi Publisher: Springer ISBN: 4431565264 Category : Medical Languages : en Pages : 410
Book Description
This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations. This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.
Author: Maria Lis-Balchin Publisher: Pharmaceutical Press ISBN: 9780853695783 Category : Health & Fitness Languages : en Pages : 490
Book Description
Aromatherapy is one of the fastest growing forms of alternative medicine in the UK and USA. Essential oils are now sold in pharmacies and aromatherapy is increasingly being used in hospitals and primary care settings.This unique book takes an analytical and scientific approach to aromatherapy practices and principles based on the scientific evidence to date.The monographs cover commonly used essential oils and their therapeutic uses, details of toxicity, bioactivity, contraindications and clinical studies. This book provides pharmacists, GPs, nurses and other healthcare professionals with reliable scientifically based information on this growing discipline.
Author: Meyer Rosen Publisher: William Andrew ISBN: 0080947107 Category : Technology & Engineering Languages : en Pages : 1097
Book Description
Novel delivery systems designed to facilitate the use of ôfountain of youthö and other functional actives is an idea whose time has come. In a rapidly growing global market eager for products that really work, accelerating market pull forces and technology push have set the stage for this foundation text. This ômust haveö book has been carefully designed for training, development and synergistic technology transfer across the personal care, cosmetic and pharmaceutical industries. It is not only intended for scientists and technologists but will also be of high interest to market development and business personnel. This book will cause a breakthrough in effective interaction among technology and marketing. It is a showcase for understanding, using and marketing the technology of why and how delivery systems work as well as current, emerging/potential applications and working formulations. Each chapter is written by one or more experts in the field. A wide range of companies serving the global marketplace are represented. These companies offer numerous types of delivery systems containing highly desirable functional actives, delivery system technology development services, and opportunities for technology licensing, mergers and acquisitions. A unique feature of the book is the use of Mind MapÖ technology to capture and present the essence of the thinking of over 80 authors in a ôBook-at-a-Glanceö Executive Overview section. This section has been specifically designed to empower decision making leading to the development of innovative product differentiation in a global context.
Author: Vitthal S. Kulkarni Publisher: Elsevier ISBN: 0815520263 Category : Science Languages : en Pages : 328
Book Description
With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.
Author: Ali Demir Sezer Publisher: BoD – Books on Demand ISBN: 9535108107 Category : Medical Languages : en Pages : 516
Book Description
This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Author: Heather A. E. Benson Publisher: John Wiley & Sons ISBN: 1119769604 Category : Medical Languages : en Pages : 580
Book Description
A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Author: Nina Dragicevic Publisher: Springer ISBN: 3662478625 Category : Medical Languages : en Pages : 387
Book Description
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.
Author: Heather A. E. Benson Publisher: John Wiley & Sons ISBN: 1118140494 Category : Medical Languages : en Pages : 393
Book Description
Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.
Author: T. Mitsui Publisher: Elsevier ISBN: 0080537499 Category : Medical Languages : en Pages : 523
Book Description
Cosmetic science covers the fields from natural sciences to human and social sciences, and is an important interdisciplinary element in various scientific disciples. New Cosmetic Science is a completely updated comprehensive review of its 35 year old counterpart Cosmetic Science. New Cosmetic Science has been written to give as many people as possible a better understanding of the subject, from scientists and technologists specializing in cosmetic research and manufacturing, to students of cosmetic science, and people with a wide range of interests concerning cosmetics.The relationship between the various disciplines comprising cosmetic science, and cosmetics, is described in Part I. In addition to discussing the safety of cosmetics, the "Usefulness of Cosmetics", rapidly becoming an important theme, is described using research examples. The latest findings on cosmetic stability are presented, as are databases, books and magazines, increasingly used by cosmetic scientists. Part II deals with cosmetics from a usage viewpoint, including skin care cosmetics, makeup cosmetics, hair care cosmetics, fragrances, body cosmetics, and oral care cosmetics. Oral care cosmetics and body cosmetics are presented with product performance, types, main components, prescriptions and manufacturing methods described for each item.This excellent volume enlightens the reader not only on current cosmetics and usage, but indicates future progress enlarging the beneficial effects of cosmetics. Products with better pharmaceutical properties (cosmeceuticals), working both physically and psychologically, are also highlighted.
Author: Emmanuel Opara Publisher: CRC Press ISBN: 0429584652 Category : Medical Languages : en Pages : 369
Book Description
This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.
Author: Kenji Sugibayashi
Author: Kenji Sugibayashi
Author: Maria Lis-Balchin
Author: Meyer Rosen
Author: Vitthal S. Kulkarni
Author: Ali Demir Sezer
Author: Heather A. E. Benson
Author: Nina Dragicevic
Author: Heather A. E. Benson
Author: T. Mitsui
Author: Emmanuel Opara