Sex Determination, Differentiation and Intersexuality in Placental Mammals PDF Download

Author: R. H. F. Hunter
Publisher: Cambridge University Press
ISBN: 9780521462181
Category : Medical
Languages : en
Pages : 360

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Book Description
How do males become male and females become female? And what are the consequences if the decision is not incisive? Drawing upon interests in animal genetics and molecular biology, the author endeavours to answer these difficult yet fascinating questions. Originally published in 1995, this book describes the genetic determination of sex and examines how sexual organs are differentiated. Using examples of intersexuality, chimaeras and asymmetries, the book describes the underlying molecular basis of sex determination and sexual differentiation, and focuses on the critical role of the rate of embryonic development in these vital processes. Male precocity is a recurrent theme, as is the involvement of Sertoli cells and their secretion of anti-Müllerian hormone. An invaluable book for reproductive physiologists, geneticists and developmental biologists whose interests may extend from animal science through veterinary medicine to human clinical medicine.

Author: Stanley J. Robboy
Publisher: Elsevier Health Sciences
ISBN: 0443074771
Category : Medical
Languages : en
Pages : 1105

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Book Description
Thoroughly revised and updated to bring you state-of-the-art assistance in diagnosing pathologies of the female reproductive tract. It covers more than 1100 common, rare, benign, and malignant lesions, and tackles the questions so often asked and not answered elsewhere. All entities are illustrated by well-chosen photographs of outstanding quality. The updated text provides the latest advances in immunohistochemistry, molecular biology, and cytogenetics, as well as the most current concepts, classification and staging systems for all diseases and disorders of the female genital tract. "Road maps" at the beginning of each chapter help you navigate the book more quickly. Integrates histopathologic features with data from ancillary techniques such as immunohistochemistry and cytogenetics and discussions of the relevant clinical manifestations of gynecological diseases.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309132975
Category : Medical
Languages : en
Pages : 287

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Book Description
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Author: Leo Beukeboom
Publisher: OUP Oxford
ISBN: 0191631396
Category : Science
Languages : en
Pages : 243

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Book Description
Sexual reproduction is a fundamental aspect of life. It is defined by the occurrence of meiosis and the fusion of two gametes of different sexes or mating types. Sex-determination mechanisms are responsible for the sexual fate and development of sexual characteristics in an organism, be it a unicellular alga, a plant, or an animal. In many cases, sex determination is genetic: males and females have different alleles or different genes that specify their sexual morphology. In animals, this is often accompanied by chromosomal differences. In other cases, sex may be determined by environmental (e.g. temperature) or social variables (e.g. the size of an organism relative to other members of its population). Surprisingly, sex-determination mechanisms are not evolutionarily conserved but are bewilderingly diverse and appear to have had rapid turnover rates during evolution. Evolutionary biologists continue to seek a solution to this conundrum. What drives the surprising dynamics of such a fundamental process that always leads to the same outcome: two sex types, male and female? The answer is complex but the ongoing genomic revolution has already greatly increased our knowledge of sex-determination systems and sex chromosomes in recent years. This novel book presents and synthesizes our current understanding, and clearly shows that sex-determination evolution will remain a dynamic field of future research. The Evolution of Sex Determination is an advanced, research level text suitable for graduate students and researchers in genetics, developmental biology, and evolution.

Author: Manuela Simoni
Publisher: Springer
ISBN: 9783319444406
Category : Medical
Languages : en
Pages : 1364

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Book Description
This book provides a comprehensive overview of endocrinology of the male reproductive system, explaining how it works and how, sometimes, it fails to work. World-class specialists present state of the art knowledge on all aspects, including anatomy, physiology, molecular biology, genetics, pathophysiology, clinical manifestations of testicular diseases, endocrine aspects of andrological and sexual diseases, and therapy. Extensive consideration is given to sexual development, testicular function, the clinical approach to disorders of male reproduction, male hypogonadism, sexual dysfunction, and male infertility. In addition, sociodemographic, psychological, and ethical aspects of male reproductive disorders are discussed. The book is intended as a major reference for endocrinologists, andrologists, and sexologists, as well as basic and clinical scientists. It is published as part of the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.

Author: George L. Mutter
Publisher: Elsevier Health Sciences
ISBN: 0702055441
Category : Medical
Languages : en
Pages : 905

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Book Description
Covering a comprehensive range of common, rare, benign and malignant lesions, Pathology of the Female Reproductive Tract, 3rd Edition, authored by an international panel of subspecialty experts, brings you the latest scientific and diagnostic information for diseases of the female reproductive tract. From basic concepts of pathophysiology and diagnostic criteria to clinical correlation, this updated medical reference book delivers an integrated and practical approach to diagnosis and management of women with reproductive tract disorders. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Quickly and easily access key information with user-friendly bullet points, diagnostic flowcharts, decision-making algorithms, summary tables, and take-home messages, as well as a "Road Map" at the beginning of each chapter for effortless navigation. - Avoid diagnostic errors with the help of practical, expert advice on common pitfalls in differential diagnosis. - Take optimal advantage of the most recent and clinically useful ancillary diagnostic methods, including molecular biomarkers, immunohistochemistry, and genetic studies. - Provide the most accurate and up-to-date diagnostic and prognostic indicators possible by familiarizing yourself with the latest classification and staging systems for all diseases and disorders of the female genital tract. - Stay completely current on the latest histological and molecular standards for diagnosis and prognosis. - Clearly visualize the appearance of each tumor or tumor-like lesion being discussed through improved and updated images.

Author:
Publisher:
ISBN:
Category : Electronic journals
Languages : en
Pages : 674

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Book Description

Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 9780470843468
Category : Science
Languages : en
Pages : 286

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Book Description
Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice. This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms. By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.

Author: Kazuya Kobayashi
Publisher: Springer
ISBN: 4431566090
Category : Science
Languages : en
Pages : 783

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Book Description
This book provides new insights into the universality of biological systems in animal reproduction and development by a comparative study of a variety of mechanisms in animals ranging from basal invertebrates to vertebrates, including mammals. Animals accomplish genetic diversity through meiosis and fertilization, and during embryogenesis animals must produce specialized cell types, including germ cells, in accordance with their individual body plan. This series of phenomena is essential to the continuity of life in the animal kingdom, and animals show various reproductive and developmental strategies. This volume, comprising four parts, reviews animal kingdom diversity, including reproductive strategies and germ cell differentiation mechanisms (Part 1), sex determination and differentiation (Part2), the mechanisms of fertilization (Part 3), and body axis formation (Part 4). Readers will find descriptions of the reproduction or development of 180 species, 13 phyla, 35 classes, 74 orders, 117 families, and 151 genera in this book. Of particular interest is the diversity of molecules and mechanisms used to achieve the same biological purpose in different animals. Undergraduates, graduate students, and professional scientists who want a deeper understanding of animal reproductive and developmental mechanisms will find this book to be of great value.

Author: R.S. Verma
Publisher: Elsevier
ISBN: 0080526179
Category : Medical
Languages : en
Pages : 387

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Book Description
The Genetical Theory of Natural Selection by R.A. Fisher (1930) dictated that sexual dimorphisms may depend upon a single medelian factor. This could be true for some species but his suggestion could not take off the ground as gender in Drosophila is determined by the number of X chromosomes. Technical advances in molecular biology have revived the initial thinking of Fisher and dictate that TDF or SRY genes in humans or Tdy in mice are sex determining genes. The fortuitous findings of XX males and XY female, which are generally termed sex reversal phenomenon, are quite bewildering traits that have caused much amazement concerning the pairing mechanism(s) of the pseudoautosomal regions of human X and Y chromosomes at meiosis. These findings have opened new avenues to explore further the genetic basis of sex determination at the single gene level.The aim of the fourth volume, titled Genetics of Sex Determination is to reflect on the latest advances and future investigative directions, encompassing 10 chapters. Commissioned several distinguished scientists, all pre-eminent authorities in each field to shed their thoughts concisely but epitomise their chapters with an extended bibliography. Obviously, during the past 60 years, the metoric advances are voluminous and to cover every account of genes, chromosomes, and sex in a single volume format would be a herculean task. Therefore, a few specific topics are chosen, which may be of great interest to scientists and clinicians. The seasoned scientists who love to inquire about the role of genes in sex determination should find the original work of these notable contributors very enlightening. This volume is intended for advanced students who want to keep abreast as well as for those who indulge in the search for genes of sex determination.