Author: Malcolm Mann
Publisher:
ISBN: 9780230424821
Category :
Languages : en
Pages : 127
Book Description
Laser A2 : [new level]. Class audio CD : includes material for KET
Author: Malcolm Mann
Publisher:
ISBN: 9780230424821
Category :
Languages : en
Pages : 127
Book Description
Publisher:
ISBN: 9780230424821
Category :
Languages : en
Pages : 127
Book Description
Destroyer of Worlds
Author: Larry Niven
Publisher: Macmillan
ISBN: 9780765361776
Category : Fiction
Languages : en
Pages : 452
Book Description
The third book in the trilogy--following "Fleet of Worlds" and "Juggler of Worlds--Destroyer of Worlds" is set 200 years before the discovery of Ringworld.
Publisher: Macmillan
ISBN: 9780765361776
Category : Fiction
Languages : en
Pages : 452
Book Description
The third book in the trilogy--following "Fleet of Worlds" and "Juggler of Worlds--Destroyer of Worlds" is set 200 years before the discovery of Ringworld.
Endoplasmic Reticulum Stress in Health and Disease
Author: Patrizia Agostinis
Publisher: Springer Science & Business Media
ISBN: 9400743513
Category : Medical
Languages : en
Pages : 448
Book Description
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
Publisher: Springer Science & Business Media
ISBN: 9400743513
Category : Medical
Languages : en
Pages : 448
Book Description
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
New Trends in Cancer for the 21st Century
Author: Antonio Llombart Bosch
Publisher: Springer Science & Business Media
ISBN: 9780306477621
Category : Medical
Languages : en
Pages : 312
Book Description
The latest advances in cancer research include basic research and its derived diagnostic, clinical and therapeutic applications. The book New Trends in Cancer for the 21st Century is written by individuals such as: molecular biologists whose tasks are, after sequencing the human genome, to decipher those new genes and pathways involved in the carcinogenesis process; clinical and molecular pathologists, who apply these discoveries for the molecular diagnosis and characterization of the tumour; and clinical oncologists, who treat patients. Pharmacogenetics introduces new perspectives in the translational fields with the design of drugs against specific targets, which are in clinical trials phases in 2003. Several organizations such as the EORTC (European Organization for Research and Treatment of Cancer) and the OECI (Organization of European Cancer Institutes) and comprehensive cancer centres play a crucial role in focusing cancer research on all these areas.
Publisher: Springer Science & Business Media
ISBN: 9780306477621
Category : Medical
Languages : en
Pages : 312
Book Description
The latest advances in cancer research include basic research and its derived diagnostic, clinical and therapeutic applications. The book New Trends in Cancer for the 21st Century is written by individuals such as: molecular biologists whose tasks are, after sequencing the human genome, to decipher those new genes and pathways involved in the carcinogenesis process; clinical and molecular pathologists, who apply these discoveries for the molecular diagnosis and characterization of the tumour; and clinical oncologists, who treat patients. Pharmacogenetics introduces new perspectives in the translational fields with the design of drugs against specific targets, which are in clinical trials phases in 2003. Several organizations such as the EORTC (European Organization for Research and Treatment of Cancer) and the OECI (Organization of European Cancer Institutes) and comprehensive cancer centres play a crucial role in focusing cancer research on all these areas.
Poor Richard's Almanack
Author: Benjamin Franklin
Publisher:
ISBN:
Category : Almanacs
Languages : en
Pages : 68
Book Description
Publisher:
ISBN:
Category : Almanacs
Languages : en
Pages : 68
Book Description
The Four Gospels as Historical Records
The Terrible and Wonderful Reasons Why I Run Long Distances
Author: Matthew Inman
Publisher: Andrews Mcmeel+ORM
ISBN: 1449460992
Category : Humor
Languages : en
Pages : 158
Book Description
This is not just a book about running. It's a book about cupcakes. It's a book about suffering. It's a book about gluttony, vanity, bliss, electrical storms, ranch dressing, and Godzilla. It's a book about all the terrible and wonderful reasons we wake up each day and propel our bodies through rain, shine, heaven, and hell. From #1 New York Times best-selling author, Matthew Inman, AKA The Oatmeal, comes this hilarious, beautiful, poignant collection of comics and stories about running, eating, and one cartoonist's reasons for jogging across mountains until his toenails fall off. Containing over 70 pages of never-before-seen material, including "A Lazy Cartoonist's Guide to Becoming a Runner" and "The Blerch's Guide to Dieting," this book also comes with Blerch race stickers.
Publisher: Andrews Mcmeel+ORM
ISBN: 1449460992
Category : Humor
Languages : en
Pages : 158
Book Description
This is not just a book about running. It's a book about cupcakes. It's a book about suffering. It's a book about gluttony, vanity, bliss, electrical storms, ranch dressing, and Godzilla. It's a book about all the terrible and wonderful reasons we wake up each day and propel our bodies through rain, shine, heaven, and hell. From #1 New York Times best-selling author, Matthew Inman, AKA The Oatmeal, comes this hilarious, beautiful, poignant collection of comics and stories about running, eating, and one cartoonist's reasons for jogging across mountains until his toenails fall off. Containing over 70 pages of never-before-seen material, including "A Lazy Cartoonist's Guide to Becoming a Runner" and "The Blerch's Guide to Dieting," this book also comes with Blerch race stickers.
Wasteland with Words
Author: Sigurður Gylfi Magnússon
Publisher: Reaktion Books
ISBN: 1861897332
Category : History
Languages : en
Pages : 290
Book Description
Iceland is an enigmatic island country marked by contradiction: it’s a part of Europe, yet separated from it by the Atlantic Ocean; it’s seemingly inhospitable, yet home to more than 300,000. Wasteland with Words explores these paradoxes to uncover the mystery of Iceland. In Wasteland with Words Sigurdur Gylfi Magnússon presents a wide-ranging and detailed analysis of the island’s history that examines the evolution and transformation of Icelandic culture while investigating the literary and historical factors that created the rich cultural heritage enjoyed by Icelanders today. Magnússon explains how a nineteenth-century economy based on the industries of fishing and agriculture—one of the poorest in Europe—grew to become a disproportionately large economic power in the late twentieth century, while retaining its strong sense of cultural identity. Bringing the story up to the present, he assesses the recent economic and political collapse of the country and how Iceland has coped. Throughout Magnússon seeks to chart the vast changes in this country’s history through the impact and effect on the Icelandic people themselves. Up-to-date and fascinating, Wasteland with Words is a comprehensive study of the island’s cultural and historical development, from tiny fishing settlements to a global economic power.
Publisher: Reaktion Books
ISBN: 1861897332
Category : History
Languages : en
Pages : 290
Book Description
Iceland is an enigmatic island country marked by contradiction: it’s a part of Europe, yet separated from it by the Atlantic Ocean; it’s seemingly inhospitable, yet home to more than 300,000. Wasteland with Words explores these paradoxes to uncover the mystery of Iceland. In Wasteland with Words Sigurdur Gylfi Magnússon presents a wide-ranging and detailed analysis of the island’s history that examines the evolution and transformation of Icelandic culture while investigating the literary and historical factors that created the rich cultural heritage enjoyed by Icelanders today. Magnússon explains how a nineteenth-century economy based on the industries of fishing and agriculture—one of the poorest in Europe—grew to become a disproportionately large economic power in the late twentieth century, while retaining its strong sense of cultural identity. Bringing the story up to the present, he assesses the recent economic and political collapse of the country and how Iceland has coped. Throughout Magnússon seeks to chart the vast changes in this country’s history through the impact and effect on the Icelandic people themselves. Up-to-date and fascinating, Wasteland with Words is a comprehensive study of the island’s cultural and historical development, from tiny fishing settlements to a global economic power.
The Hunter's Guide to Butchering, Smoking, and Curing Wild Game and Fish
Author: Philip Hasheider
Publisher: Zenith Press
ISBN: 0760343756
Category : Cooking
Languages : en
Pages : 229
Book Description
From field to table, The Hunter's Guide to Butchering, Smoking, and Curing Wild Game and Fish gives you all you need to know to harvest your big game, small game, fowl, and fish.
Publisher: Zenith Press
ISBN: 0760343756
Category : Cooking
Languages : en
Pages : 229
Book Description
From field to table, The Hunter's Guide to Butchering, Smoking, and Curing Wild Game and Fish gives you all you need to know to harvest your big game, small game, fowl, and fish.
Using New Testament Greek in Ministry
Author: David Alan Black
Publisher: Baker Academic
ISBN: 0801010438
Category : Religion
Languages : en
Pages : 128
Book Description
Here are all the tools pastors and teachers need to mine the Greek text and other language resources for the enhancement of personal study and sermon content.
Publisher: Baker Academic
ISBN: 0801010438
Category : Religion
Languages : en
Pages : 128
Book Description
Here are all the tools pastors and teachers need to mine the Greek text and other language resources for the enhancement of personal study and sermon content.