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Regulation of Carbohydrate Metabolism by Exogenous Glucagon in Lactating Cows

Regulation of Carbohydrate Metabolism by Exogenous Glucagon in Lactating Cows PDF Author: Pengxiang She
Publisher:
ISBN:
Category :
Languages : en
Pages : 280

Book Description
Forty early lactation Holstein cows were assigned to four groups of a 2 x 2 factorial design with two nutritional backgrounds (normal and ketosis-susceptible) and two levels of glucagon (O and 10 mg/d from 21 to 35 days postpartum) to study the regulation of glucose metabolism. In normal cows, plasma glucagon and glucose concentrations increased by about 6-fold and 10 mg/dl, respectively, during glucagon infusions, but plasma nonesterified fatty acids, [Beta]-hydroxybutyrate, and urea nitrogen did not change. Liver glycogen decreased at d 2 of glucagon infusions, but it was restored by d 7 and increased to 169% of baseline at 3 d after cessation of infusions. Milk and milk protein yield, but not milk lactose yield, decreased during glucagon infusions.

Regulation of Carbohydrate Metabolism by Exogenous Glucagon in Lactating Cows

Regulation of Carbohydrate Metabolism by Exogenous Glucagon in Lactating Cows PDF Author: Pengxiang She
Publisher:
ISBN:
Category :
Languages : en
Pages : 280

Book Description
Forty early lactation Holstein cows were assigned to four groups of a 2 x 2 factorial design with two nutritional backgrounds (normal and ketosis-susceptible) and two levels of glucagon (O and 10 mg/d from 21 to 35 days postpartum) to study the regulation of glucose metabolism. In normal cows, plasma glucagon and glucose concentrations increased by about 6-fold and 10 mg/dl, respectively, during glucagon infusions, but plasma nonesterified fatty acids, [Beta]-hydroxybutyrate, and urea nitrogen did not change. Liver glycogen decreased at d 2 of glucagon infusions, but it was restored by d 7 and increased to 169% of baseline at 3 d after cessation of infusions. Milk and milk protein yield, but not milk lactose yield, decreased during glucagon infusions.

Metabolic Responses of Lactating Dairy Cows to Exogenous Glucagon

Metabolic Responses of Lactating Dairy Cows to Exogenous Glucagon PDF Author: Gerd Bobe
Publisher:
ISBN:
Category :
Languages : en
Pages : 320

Book Description
Fatty liver is a major metabolic disorder of dairy cows in early lactation that compromises their health status and reproductive performance and in clinical cases decreases milk production and feed intake. Fatty liver can be treated with 14-d continuous, intravenous infusions of 10 mg/d of glucagon. The objective of the current study was to test whether treatment of fatty liver with 14-d subcutaneous injections of glucagon at 7.5 or 15 mg/d, which is more practical than infusion, would cause similar metabolic responses and improve health status and reproductive performance of dairy cows in early lactation. In the main study, multiparous Holstein cows (n=32) were grouped on the basis of their liver triacylglycerol concentration at d 8 postpartum into "Normal" (n=8; triacylglycerol 1% liver wet wt) and "Susceptible" (n=24; triacylglycerol 1% liver wet wt) cows. "Susceptible" cows were assigned randomly to three groups and beginning at d 8 postpartum received 0 (same for "Normal" cows), 2.5, or 5 mg of glucagon in 60 ml 0.15 M NaCl by subcutaneous injections every 8 h for 14 d. Subcutaneous injections of 15 mg/d of glucagon consistently increased concentrations of plasma glucose and insulin for 4 h, decreased concentrations of liver triacylglycerol in cows older than 3.5 years, and tended to decrease concentrations of plasma NEFA and BHBA. The effects of 15 mg/d of glucagon were not limited to the treatment period, because glucagon decreased the incidence of mastitis and days to first ovarian activity after the injection period. These results document that subcutaneous injections of 15 mg/d or glucagon improve metabolic status throughout the injection period and have the potential to treat fatty liver in older cows. The improved metabolic status in cows treated with 15 mg/d of glucagon in early lactation has long-term beneficial effects by improving health status and reproductive performance during the entire lactation.

Ruminant Physiology

Ruminant Physiology PDF Author: Pierre Cronjé
Publisher: CABI
ISBN: 9780851997124
Category : Electronic books
Languages : en
Pages : 492

Book Description
The International Symposium on Ruminant Physiology (ISRP) is the premier forum for presentation and discussion of advances in knowledge of the physiology of ruminant animals. This book brings together edited versions of the keynote review papers presented at the symposium.

Physiological Aspects of Digestion and Metabolism in Ruminants

Physiological Aspects of Digestion and Metabolism in Ruminants PDF Author: T. Tsuda
Publisher: Academic Press
ISBN: 0323138616
Category : Technology & Engineering
Languages : en
Pages : 806

Book Description
This volume is comprised of invited papers presented at the Seventh International Symposium on Ruminant Physiology, held in Sendai, Japan, in September 1989. Papers are invited on the recommendations of 300 international experts. The proceedings of this symposia provides the most comprehensive coverage available of current research in ruminant physiology.

Aspirin and Related Drugs

Aspirin and Related Drugs PDF Author: Kim D. Rainsford
Publisher: CRC Press
ISBN: 0203646967
Category : Health & Fitness
Languages : en
Pages : 801

Book Description
Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. Highlighting the historical evolution of the salicylates and the commercial development of

Oxford Textbook of Endocrinology and Diabetes

Oxford Textbook of Endocrinology and Diabetes PDF Author: John A.H. Wass
Publisher: Oxford University Press, USA
ISBN: 0199235295
Category : Medical
Languages : en
Pages : 2158

Book Description
Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.

Diabetes Mellitus in Children

Diabetes Mellitus in Children PDF Author: Mark A. Sperling
Publisher:
ISBN: 9781416027539
Category : Children
Languages : en
Pages : 0

Book Description


Environmental Physiology of Livestock

Environmental Physiology of Livestock PDF Author: R. J. Collier
Publisher: John Wiley & Sons
ISBN: 0813811767
Category : Science
Languages : en
Pages : 360

Book Description
Environmental stress is one of the most significant factors affecting livestock performance and health, and it is only expected to increase with effects of global warming. Environmental Physiology of Livestock brings together the latest research on environmental physiology, summarizing progress in the field and providing directions for future research. Recent developments in estimating heat stress loads are discussed, as well as key studies in metabolism, reproduction, and genetic expressions. Environmental Physiology of Livestock begins with a survey of current heat indexing tools, highlighting recent discoveries in animal physiology, changes in productivity levels, and new technologies available to better estimate stress response. Using this synopsis as a point of orientation, later chapters hone in on major effects of heat stress, including changing metabolic pathways and nutrient requirements, endocrine regulation of acclimation to environmental stress, and reduced reproductive performance. The text concludes with a thorough discussion of environmental effects on gene expressions, providing important insight for future breeding practices. Environmental Physiology of Livestock is a globally contributed volume and a key resource for animal science researchers, geneticists, and breeders.

Designing Foods

Designing Foods PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309037956
Category : Medical
Languages : en
Pages : 384

Book Description
This lively book examines recent trends in animal product consumption and diet; reviews industry efforts, policies, and programs aimed at improving the nutritional attributes of animal products; and offers suggestions for further research. In addition, the volume reviews dietary and health recommendations from major health organizations and notes specific target levels for nutrients.

International Textbook of Diabetes Mellitus

International Textbook of Diabetes Mellitus PDF Author: R. A. DeFronzo
Publisher: John Wiley & Sons
ISBN: 1118387678
Category : Medical
Languages : en
Pages : 1200

Book Description
The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.