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Author: T. Chiba Publisher: Karger Medical and Scientific Publishers ISBN: 3318024155 Category : Medical Languages : en Pages : 130
Book Description
The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.
Author: T. Chiba Publisher: Karger Medical and Scientific Publishers ISBN: 3318024155 Category : Medical Languages : en Pages : 130
Book Description
The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.
Author: T. Chiba Publisher: Karger Medical and Scientific Publishers ISBN: 3318024163 Category : Medical Languages : en Pages : 130
Book Description
The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.
Author: Lars Olbe Publisher: Birkhäuser ISBN: 3034887957 Category : Medical Languages : en Pages : 245
Book Description
Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specific target - the proton pump. The clinical superiority of the proton pump inhibitors is due not only to their high efficacy but also to the long duration of the acid inhibition in comparison with other antisecretory drugs. At present when drug discovery mostly relies on identification and characterization of potential targets by genome research, molecular biology, combinatorial chemistry and automated screening, it seems worthwhile to present the development of the tITst proton pump inhibitor - omeprazol- starting from a chemical structure with an observed antisecretory effect but also severe toxic effects that had to be eliminated. As always, basic and applied research operate luind in hand to optimize the delicate balance be tween efficacy and safety of a new drug. This goal often involves time and many different specialists.
Author: Ruben Vardanyan Publisher: Academic Press ISBN: 0124115241 Category : Medical Languages : en Pages : 870
Book Description
Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
Author: Publisher: Academic Press ISBN: 0128173173 Category : Medical Languages : en Pages : 288
Book Description
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Author: Irvin M. Modlin Publisher: Lippincott Williams & Wilkins ISBN: 9780781741231 Category : Medical Languages : en Pages : 556
Book Description
This textbook explores the history, biology, and treatment of acid related diseases, including gastric and duodenal ulcer disease, gastroesophageal reflux disease (GERD), and the role of H. pylori. The text offers thorough coverage of the subject matter, with an in-depth historical and biological focus. Equal focus is given to the biology and pharmacology of acid secretion and to the specific disease states of ulcers and GERD. This edition is full of new full-color medical illustrations of all aspects of this topic.
Author: Barbara Parker Publisher: Nova Science Publishers ISBN: 9781634828901 Category : Medical Languages : en Pages : 0
Book Description
Proton pump inhibitors (PPIs) have become a mainstay of therapy not only in the practice of gastroenterology, but also for general medicine and even for the general public. Recently, proton pump inhibitors have been associated with a number of potential complications including impaired vitamin and mineral absorption, altered drug metabolism and increased risk for infections. The outline for the basis for these reported risks are examined in this book, the current clinical evidence is discussed, and the authors offer insight into the likely clinical significance of each complication. Furthermore, the pathophysiology of acid secretion and inhibition, with a specific focus on the pharmacological principles surrounding the use of PPIs are reviewed. Relevant information on the management of acid-related disordered is provided for clinicians. Other chapters explore the current literature on potential complications associated with long-term PPI use, the benefits and risks of routine use of proton pump inhibitors in the intensive care unit (ICU), often associated with adverse events such as a significantly increased risk of infectious complications, and the use and misuse of proton pump inhibitors in the general population.
Author: Anas Rasheed Publisher: Createspace Independent Publishing Platform ISBN: 9781544607733 Category : Languages : en Pages : 46
Book Description
Proton-pump inhibitors (PPIs) have emerged as the drug class of choice for treating patients with acid-related diseases, including gastro esophageal reflux disease (GERD), duodenal ulcer, and gastric ulcer. PPIs are also effective in treating patients with Barrett's esophagus and Zollinger-Ellison syndrome. These agents inhibit gastric acid secretion by targeting the gastric acid pump, H+ K+ adenosine triphosphatase (ATPase), in the canalicular membrane of the parietal cell. The regulation of acid secretion is a complex process involving many cell types, hormones, and mediators, but these processes converge in a final common step involving H+ K+ ATPase. As a result, PPIs effectively inhibit acid secretion in a manner independent of the processes that stimulate the parietal cell. Each member of the PPI class omeprazole, lansoprazole, pantoprazole and rabeprazole has been shown to be effective and well tolerated in randomized, controlled clinical trials.
Author: Anas Rasheed Publisher: Createspace Independent Publishing Platform ISBN: 9781544767093 Category : Languages : en Pages : 72
Book Description
Proton-pump inhibitors (PPIs) have emerged as the drug class of choice for treating patients with acid-related diseases, including gastro esophageal reflux disease (GERD), duodenal ulcer, and gastric ulcer. PPIs are also effective in treating patients with Barrett's esophagus and Zollinger-Ellison syndrome. These agents inhibit gastric acid secretion by targeting the gastric acid pump, H+ K+ adenosine triphosphatase (ATPase), in the canalicular membrane of the parietal cell. The regulation of acid secretion is a complex process involving many cell types, hormones, and mediators, but these processes converge in a final common step involving H+ K+ ATPase. As a result, PPIs effectively inhibit acid secretion in a manner independent of the processes that stimulate the parietal cell. Each member of the PPI class omeprazole, lansoprazole, pantoprazole and rabeprazole has been shown to be effective and well tolerated in randomized, controlled clinical trials.
Author: T. Chiba
Author: T. Chiba
Author: T. Chiba
Author: Richard H. Hunt
Author: Lars Olbe
Author: Ruben Vardanyan
Author: 
Author: Irvin M. Modlin
Author: Barbara Parker
Author: Anas Rasheed
Author: Anas Rasheed