Portal Hypertension in the 21st Century PDF Download

Author: R. J. Groszmann
Publisher:
ISBN: 9789400710436
Category :
Languages : en
Pages : 392

View

Book Description

Author: R.J. Groszmann
Publisher: Springer Science & Business Media
ISBN: 9400710429
Category : Medical
Languages : en
Pages : 366

View

Book Description
Portal hypertension is the most important complication of a great variety of both acute and chronic liver diseases. Nevertheless, hepatic cirrhosis is the most frequent cause of portal hypertension. Gastrointestinal bleeding due to rupture of oesophageal varices is, without doubt, the most severe complication of portal hypertension. At present, great advances are being made in the pathophysiology and in the development of new therapeutic tools for controlling and preventing this severe clinical event. This book contains the papers presented and discussed during the Symposium on 'Portal Hypertension in the 21st Century', held in Montréal, Canada, in April 2004, and sponsored by Axcan Pharma Inc. and NicOx S.A. There are eight sections covering basic mechanisms, new drugs, prevention and current treatment of variceal bleeding, prevention of recurrent bleeding and hepatic hemodynamic monitoring. An international faculty of authors have contributed chapters at an outstanding scientific level which will be vital reading for scientists and clinicians alike.

Author: Arun J. Sanyal
Publisher:
ISBN:
Category :
Languages : en
Pages : 297

View

Book Description

Author: Gerond V. Lake-Bakaar
Publisher:
ISBN: 9781536120523
Category : HEALTH & FITNESS
Languages : en
Pages : 150

View

Book Description
Book Description:The cirrhotic liver is significantly more vulnerable to injury. This vulnerability is particularly evident after the advent of portal hypertension. In the normal liver, up to 75 percent can be resected without decompensation. By contrast, in the cirrhotic liver with portal hypertension, liver decompensation can occur even after less than 50 percent of the liver is resected.This book, "Portal Hypertension: New Insights" begins with an attempt to provide insights into this unanswered puzzle. The normal liver is soft and elastic. By contrast, the cirrhotic liver is inelastic and rigid. Flow in rigid tubes is governed by the Hagen-Poiseuille law. The law dictates that pressure gradient increases exponentially by the fourth power of the radius of the rigid sinusoid. This makes the cirrhotic liver virtually incapable of accommodating any increase in flow. The increase in pressure gradient is equivalent to the fourth power of the vessel radius.The first chapter explores the major new insight that decompensation in the cirrhotic liver is related to the loss of elasticity and the development of vessel wall rigidity, which thereafter subjects flow in the hepatic sinusoids to the Hagen-Poiseuille law.The rest of the book addresses portal hypertension in its clinical context. It invites the reader to survey multiple avenues associated with portal hypertension, including idiopathic non-cirrhotic portal hypertension, INCPH and non-alcoholic fatty liver disease, NAFLD. It also includes chapters on relationships between portal hypertension, the gastrointestinal system and the renal system. In general, the book provides several new insights into portal hypertension.

Author: Roberto de Franchis
Publisher: John Wiley & Sons
ISBN: 1405173122
Category : Medical
Languages : en
Pages : 424

View

Book Description
Current recommendations for diagnosis and management of portal hypertension This book presents the proceedings from the 'Baveno IV International Consensus Workshop: Methodology of diagnosis and treatment in portal hypertension' which was held on April 28-29, 2005 in Baveno, Italy. These meetings are important to raise awareness of difficulties and defining some key events related to portal hypertension and variceal bleeding. They also help to produce guidelines aimed at improving trials conducted in this field. Since the Baveno III meeting, new diagnostic tools, new drugs and new treatment strategies for portal hypertension have been developed. Therefore this book updates recommendations for diagnosis and management. It includes evidence from the workshop on pathophysiology, natural history, methods of evaluation and established treatments of portal hypertension. In addition, this books looks at important emerging topics such as the role of coagulation disturbances, portopulmonary hypertension and the hepatopulmonary syndrome, hepato-renal syndrome, spontaneous bacterial peritonitis, and infections. This gives clinicians and investigators current evidence and helps to inform treatment decisions.

Author: Stefano Guandalini
Publisher: Springer
ISBN: 3319171690
Category : Medical
Languages : en
Pages : 889

View

Book Description
This textbook provides a comprehensive and state-of-the-art overview of the major issues specific to the field of pediatric gastroenterology, hepatology, and nutrition. The first part of the book, Gastroenterology and Nutrition, presents in a systematic way the overall scope of issues encountered by children (newborn to teenagers) suffering from disorders of the gastrointestinal tract, pancreas and/or presenting nutritional issues. These chapters are structured in logical sections to facilitate consultation and include major topics ranging from congenital disorders to gastrointestinal problems of the newborn, infectious diseases of the gastrointestinal tract, and approach to nutritional problems in the various pediatric ages. The second part of the book, Hepatology, is articulated in a series of chapters which present a comprehensive review of congenital and acquired disorders of the biliary tract and liver. This section also includes a critical analysis of available diagnostic and therapeutic procedures and future perspectives. Written by experts in the field, Textbook of Pediatric Gastroenterology, Hepatology and Nutrition: A Comprehensive Guide to Practice constitutes a much needed, innovative resource combining updated, reliable and comprehensive information with agile consultation for a streamlined approach to the care of children with such disorders.

Author: Lorenzo D'Antiga
Publisher: Springer
ISBN: 3319964003
Category : Medical
Languages : en
Pages : 829

View

Book Description
This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers.

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309452961
Category : Medical
Languages : en
Pages : 583

View

Book Description
In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

Author: Thomas D. Boyer
Publisher: Saunders
ISBN:
Category : Medical
Languages : en
Pages : 852

View

Book Description
Long considered the defining work in Hepatology, this trusted 2-volume masterwork has been refocused to zero in on just the clinical knowledge you need to provide today's best patient care. The most comprehensive text on the subject, this book is still thoroughly grounded in basic science-but now that science is focused on the most clinically relevant developments. Find definitive coverage of all aspects of liver disease in a new full-color format that keeps pace with your evolving practice. Log on to www.hepatologytext.com to find the entire contents of the 2-volume set online and fully searchable for speedy consultation wherever you go, plus a downloadable image collection for your presentations. Covers all liver diseases currently seen in clinical practice-in two clinically focused volumes. Replaces previous editions' basic science section with the new, more concise "Pathophysiology of Therapeutic Targets" section. Highlights key references, all current and up to date, to help you get straight to the significant literature. Contains new contributions from recognized experts worldwide. Presents hundreds of detailed illustrations, now in full color! Includes access to the entire contents online, completely searchable, plus hundreds of downloadable illustrations, review questions and answers, and more! A new full-color format and a totally new organization make reference much easier and faster. Includes access to the entire contents online, completely searchable, with an electronic image collection full of more than 400 illustrations (many in color) downloadable into presentation software, and review questions and answers.

Author: Frederick J. Suchy
Publisher: Cambridge University Press
ISBN: 1108911374
Category : Medical
Languages : en
Pages : 875

View

Book Description
Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.