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Author: Ariel Fernández Publisher: Springer ISBN: 3319308521 Category : Science Languages : en Pages : 490
Book Description
This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics. The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective. The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines.
Author: Ariel Fernández Publisher: Springer ISBN: 3319308521 Category : Science Languages : en Pages : 490
Book Description
This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics. The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective. The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines.
Author: Ariel Fernández Stigliano Publisher: Springer ISBN: 3319168509 Category : Science Languages : en Pages : 380
Book Description
The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.
Author: Hans Frauenfelder Publisher: Springer Science & Business Media ISBN: 1441910441 Category : Science Languages : en Pages : 423
Book Description
Provides an introduction to the structure and function of biomolecules --- especially proteins --- and the physical tools used to investigate them The discussion concentrates on physical tools and properties, emphasizing techniques that are contributing to new developments and avoiding those that are already well established and whose results have already been exploited fully New tools appear regularly - synchrotron radiation, proton radiology, holography, optical tweezers, and muon radiography, for example, have all been used to open new areas of understanding
Author: Jean-francois Allemand Publisher: World Scientific ISBN: 9814616494 Category : Science Languages : en Pages : 199
Book Description
Do you often lose your keys? You will find in this book the best strategy to find them, or at least the one deduced from statistical physics. What is the link with biology? Some proteins use the same strategy to find their target inside a living cell. This example illustrates one of the many links between physics and biology. These links result from an intense research activity in the past years at the interface between those two disciplines. This book describes some of the most recent progresses at this interface: from instrumental progresses used in biology to the mechanical description of a cell, to molecular motors, from brain activity mechanisms to auditory or sensory perception. Many fields are covered from the molecular to the scale at the organ level. A few biological notions are presented in the first chapter that may help to access the biological aspects of the others. In the end this book may interest people passionate in science, from the simple amateur to the advanced researcher level.
Author: Henrik Flyvbjerg Publisher: Springer Science & Business Media ISBN: 3540457011 Category : Science Languages : en Pages : 591
Book Description
Aimed at those working to enter this rapidly developing field, this volume on biological physics is written in a pedagogical style by leading scientists giving explanations that take their starting point where any physicist can follow and end at the frontier of research in biological physics. These lectures describe the state-of-the-art physics of biomolecules and cells. In biological systems ranging from single biomolecules to entire cells and larger biological systems, it focuses on aspects that require concepts and methods from physics for their analysis and understanding, such as the mechanics of motor proteins; how the genetic code is physically read and managed; the machinery of protein--DNA interactions; force spectroscopy of biomolecules' velopes, cytoskeletons, and cytoplasms; polymerization forces; listeria propulsion; cell motility; lab-on-a-chip nanotechnology for single-molecule analysis of biomolecules; bioinformatics; and coding and computational strategies of the brain.
Author: Hans Frauenfelder Publisher: Springer ISBN: 9781441910431 Category : Science Languages : en Pages : 448
Book Description
Provides an introduction to the structure and function of biomolecules --- especially proteins --- and the physical tools used to investigate them The discussion concentrates on physical tools and properties, emphasizing techniques that are contributing to new developments and avoiding those that are already well established and whose results have already been exploited fully New tools appear regularly - synchrotron radiation, proton radiology, holography, optical tweezers, and muon radiography, for example, have all been used to open new areas of understanding
Author: Gabor Forgacs Publisher: Cambridge University Press ISBN: 9780521783378 Category : Science Languages : en Pages : 346
Book Description
During development cells and tissues undergo changes in pattern and form that employ a wider range of physical mechanisms than at any other time in an organism's life. This book demonstrates how physics can be used to analyze these biological phenomena. Written to be accessible to both biologists and physicists, major stages and components of the biological development process are introduced and then analyzed from the viewpoint of physics. The presentation of physical models requires no mathematics beyond basic calculus.
Author: Arne Skjeltorp Publisher: Springer Science & Business Media ISBN: 9781402023392 Category : Science Languages : en Pages : 272
Book Description
The book reviews the current experimental and theoretical knowledge of the synergism between modern physics, soft condensed matter and biology, presenting a thorough discussion of the relative role of the various fundamental interactions in such systems: electrostatic, hydrophobic, steric, conformational, van der Waals, etc. These competing interactions influence the form and topology of soft and biological matter, like polymers and proteins, leading to hierarchical structures in self-assembling systems and folding patterns sometimes described in terms of chirality, braids and knots. Finally, the competing interactions influence various bioprocesses like genetic regulation and biological evolution taking place in systems like biopolymers, macromolecules and cell membranes. The authors include theoretical physicists, soft condensed matter experimentalists, biological physicists, and molecular biologists - all leaders in their respective fields. Aside from the need to gain new, fundamental insights, the subject area is also of great importance for many applications, in that self-assembly and hierarchical assembly are important features to achieve functionality on multiple length scales. Applications range from the nanoscopic (e.g., biomolecular material and copolymeric mesophases) to the microscopic (all organic microelectronics) to the macroscopic (high-performance structural composites).
Author: Thomas Andrew Waigh Publisher: John Wiley & Sons ISBN: 0470513160 Category : Science Languages : en Pages : 436
Book Description
This book presents the fundamentals of molecular biophysics, and highlights the connection between molecules and biological phenomena, making it an important text across a variety of science disciplines. The topics covered in the book include: Phase transitions that occur in biosystems (protein crystallisation, globule-coil transition etc) Liquid crystallinity as an example of the delicate range of partially ordered phases found with biological molecules How molecules move and propel themselves at the cellular level The general features of self-assembly with examples from proteins The phase behaviour of DNA The physical toolbox presented within this text will form a basis for students to enter into a wide range of pure and applied bioengineering fields in medical, food and pharmaceutical areas.
Author: Ariel Fernández
Author: Ariel Fernández
Author: Ariel Fernández Stigliano
Author: Hans Frauenfelder
Author: Andreas Hartmann-Ferri
Author: Jean-francois Allemand
Author: Henrik Flyvbjerg
Author: Hans Frauenfelder
Author: Gabor Forgacs
Author: Arne Skjeltorp
Author: Thomas Andrew Waigh