Author: DENNIS. OSTROVSKYPublisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Palladium Catalyzed Hydrostannations of Allenes and 1,6-diynes
Author: DENNIS. OSTROVSKYPalladium Catalyzed Oxidation of Hydrocarbons
Author: P. HenryPublisher: Springer Science & Business Media
ISBN: 940099446X
Category : Science
Languages : en
Pages : 449
Book Description
The field of organometallic chemistry has emerged over the last twenty-five years or so to become one of the most important areas of chemistry, and there are no signs of abatement in the intense current interest in the subject, particularly in terms of its proven and potential application in catalytic reactions involving hydrocarbons. The development of the organometallic/ catalysis area has resulted in no small way from many contributions from researchers investigating palladium systems. Even to the well-initiated, there seems a bewildering and diverse variety of organic reactions that are promoted by palladium(II) salts and complexes. Such homogeneous reactions include oxidative and nonoxidative coupling of substrates such as olefins, dienes, acetylenes, and aromatics; and various isomerization, disproportionation, hydrogenation, dehydrogenation, car bonylation and decarbonylation reactions, as well as reactions involving formation of bonds between carbon and halogen, nitrogen, sulfur, and silicon. The books by Peter M. Maitlis - The Organic Chemistry of Palladium, Volumes I, II, Academic Press, 1971 - serve to classify and identify the wide variety of reactions, and access to the vast literature is available through these volumes and more recent reviews, including those of J. Tsuji [Accounts Chem. Res. , 6, 8 (1973); Adv. in Organometal. , 17, 141 (1979)], R. F. Heck [Adv. in Catat. , 26, 323 (1977)], and ones by Henry [Accounts Chem. Res. , 6, 16 (1973); Adv. in Organometal. , 13, 363 (1975)]. F. R. Hartley's book - The Chemistry of Platinum and Palladium, App!. Sci. Pub!.
Palladium-catalyzed Heteroannulation of Allenes
Author: Yun HePalladium Catalyzed Thiocarbonylation and Related Reactions of Functionally Substituted Alkenes and Alkynes, Allenes, and Enynes
Author: Wen Jing XiaoPalladium Catalyzed Thiocarbonylation and Related Reactions of Functionally Substituted Alkenes and Alkynes, Allenes, and Enynes
Author: Wen Jing XiaoPublisher:
ISBN:
Category : Alkenes
Languages : en
Pages : 566
Book Description
Selective Palladium-catalyzed 1,4-functionalization
Author: Joakim LöfstedtPublisher:
ISBN: 9789172654570
Category :
Languages : en
Pages : 52
Book Description
Palladium Catalysed Reactions of Allenes in Organic Synthesis
Author: Xinjie GaiPalladium Catalysed Reactions Involving Allenes
Author: Catherine TerrierPalladium Catalyzed Transformations of Allenes and Progress Towards the Total Synthesis of Nogalamycin
Author: Logan Vine (Ph.D.)Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Transition metal-catalyzed transformations of allenes are underexplored compared to other unsaturated functional groups. However, the consecutive, orthogonal double bonds of allenes represent an extremely valuable functional handle that can be manipulated to rapidly build molecular complexity. The first section of this work (Chapter 2) describes how targeted changes to the reaction conditions enable control over the mechanism of Pd-catalyzed allene cross-coupling/cyclization and cycloisomerization, irrespective of the allene substitution pattern. Both enantioenriched cyclopropanes and cyclopentenes can be obtained through axis-to-center chirality transfer from the allene precursor at room temperature. The next section (Chapter 4) demonstrates a highly stereoselective Pd-catalyzed Heck-type reaction of allenes to form 1,3-dienes in which the stereochemistry of both olefins is set simultaneously. The stereodetermining factors and a plausible mechanism for this work are proposed and both inter- and intramolecular trapping of the Ï0-allyl intermediate with an oxygen nucleophile are demonstrated. The final portion of this work will be focused on progress towards the total synthesis of Nogalamycin (NOG) (Chapter 6). NOG is a member of the glycosidic anthracyclines and shows a unique dumbbell type binding to DNA. Toxicity and relatively low antineoplastic activity have prevented NOG from clinical use, but semisynthetically accessed derivatives have shown great potential, leading to the need for a highly modular synthetic approach to access new analogs and further probe SARs. A complex bicyclic aminosugar motif creates a significant challenge for the synthesis of NOG, as there are no reliable synthetic methods to install the C℗Ơaryl-Cglycoside bond late stage. In this section, we propose a late-stage chemoenzymatic installation of the C℗Ơaryl-Cglycoside bond inspired by the biosynthetic pathway. The synthesis of the tetracyclic anthracycline core includes a key boron-directed cycloaddition, a novel SmI2 mediated ring opening of an oxanorbornadiene, and a proposed Ni-catalyzed cross electrophile coupling.
Author: Ines Bettina Köppen