Author: Johan FranzénPublisher:
ISBN: 9789172658639
Category :
Languages : en
Pages : 52
Book Description
Palladium-catalyzed Carbocyclizations of Allenes with Unsaturated Hydrocarbons
Author: Johan FranzénPublisher:
ISBN: 9789172658639
Category :
Languages : en
Pages : 52
Book Description
Studies on Palladium-catalyzed Carbocyclizations of Allene-substituted Olefins and 1,3-dienes
Author: Katja NärhiPublisher:
ISBN: 9789171551986
Category :
Languages : en
Pages : 66
Book Description
Palladium Catalyzed Oxidation of Hydrocarbons
Author: P. HenryPublisher: Springer Science & Business Media
ISBN: 940099446X
Category : Science
Languages : en
Pages : 449
Book Description
The field of organometallic chemistry has emerged over the last twenty-five years or so to become one of the most important areas of chemistry, and there are no signs of abatement in the intense current interest in the subject, particularly in terms of its proven and potential application in catalytic reactions involving hydrocarbons. The development of the organometallic/ catalysis area has resulted in no small way from many contributions from researchers investigating palladium systems. Even to the well-initiated, there seems a bewildering and diverse variety of organic reactions that are promoted by palladium(II) salts and complexes. Such homogeneous reactions include oxidative and nonoxidative coupling of substrates such as olefins, dienes, acetylenes, and aromatics; and various isomerization, disproportionation, hydrogenation, dehydrogenation, car bonylation and decarbonylation reactions, as well as reactions involving formation of bonds between carbon and halogen, nitrogen, sulfur, and silicon. The books by Peter M. Maitlis - The Organic Chemistry of Palladium, Volumes I, II, Academic Press, 1971 - serve to classify and identify the wide variety of reactions, and access to the vast literature is available through these volumes and more recent reviews, including those of J. Tsuji [Accounts Chem. Res. , 6, 8 (1973); Adv. in Organometal. , 17, 141 (1979)], R. F. Heck [Adv. in Catat. , 26, 323 (1977)], and ones by Henry [Accounts Chem. Res. , 6, 16 (1973); Adv. in Organometal. , 13, 363 (1975)]. F. R. Hartley's book - The Chemistry of Platinum and Palladium, App!. Sci. Pub!.
Palladium Catalyzed Thiocarbonylation and Related Reactions of Functionally Substituted Alkenes and Alkynes, Allenes, and Enynes
Author: Palladium Catalyzed Hydrostannations of Allenes and 1,6-diynes
Author: DENNIS. OSTROVSKYHandbook of Organopalladium Chemistry for Organic Synthesis
Author: Ei-ichi NegishiPublisher: John Wiley & Sons
ISBN: 0471473812
Category : Science
Languages : en
Pages : 1657
Book Description
Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Selective Palladium-catalyzed 1,4-functionalization
Author: Joakim LöfstedtPublisher:
ISBN: 9789172654570
Category :
Languages : en
Pages : 52
Book Description
Palladium-catalyzed Nucleophilic Addition to and Substitution of Unsaturated Hydrocarbons
Author: Ylva NilssonPublisher:
ISBN: 9789155434632
Category : Compounds, Unsaturated
Languages : en
Pages : 54
Book Description
Palladium Catalyzed Transformations of Allenes and Progress Towards the Total Synthesis of Nogalamycin
Author: Logan Vine (Ph.D.)Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Transition metal-catalyzed transformations of allenes are underexplored compared to other unsaturated functional groups. However, the consecutive, orthogonal double bonds of allenes represent an extremely valuable functional handle that can be manipulated to rapidly build molecular complexity. The first section of this work (Chapter 2) describes how targeted changes to the reaction conditions enable control over the mechanism of Pd-catalyzed allene cross-coupling/cyclization and cycloisomerization, irrespective of the allene substitution pattern. Both enantioenriched cyclopropanes and cyclopentenes can be obtained through axis-to-center chirality transfer from the allene precursor at room temperature. The next section (Chapter 4) demonstrates a highly stereoselective Pd-catalyzed Heck-type reaction of allenes to form 1,3-dienes in which the stereochemistry of both olefins is set simultaneously. The stereodetermining factors and a plausible mechanism for this work are proposed and both inter- and intramolecular trapping of the Ï0-allyl intermediate with an oxygen nucleophile are demonstrated. The final portion of this work will be focused on progress towards the total synthesis of Nogalamycin (NOG) (Chapter 6). NOG is a member of the glycosidic anthracyclines and shows a unique dumbbell type binding to DNA. Toxicity and relatively low antineoplastic activity have prevented NOG from clinical use, but semisynthetically accessed derivatives have shown great potential, leading to the need for a highly modular synthetic approach to access new analogs and further probe SARs. A complex bicyclic aminosugar motif creates a significant challenge for the synthesis of NOG, as there are no reliable synthetic methods to install the C℗Ơaryl-Cglycoside bond late stage. In this section, we propose a late-stage chemoenzymatic installation of the C℗Ơaryl-Cglycoside bond inspired by the biosynthetic pathway. The synthesis of the tetracyclic anthracycline core includes a key boron-directed cycloaddition, a novel SmI2 mediated ring opening of an oxanorbornadiene, and a proposed Ni-catalyzed cross electrophile coupling.
Palladium in Organic Synthesis
Author: Jiro TsujiPublisher: Springer
ISBN: 9783642063084
Category : Science
Languages : en
Pages : 0
Book Description
Palladium is a remarkable metal. In particular, organopalladium chemistry has made remarkable progress over the last 30 years. That progress is still continuing, without any end in sight. This book presents a number of accounts and reviews on the novel Pd-catalyzed reactions discovered mainly in the last five years. The book covers Pd-catalyzed reactions that are new – entirely different from the more standard ones. Topics such as new reactions involving ß-carbon elimination and formation of palladacycles as key reactions, cross-coupling of unactivated alkyl electrophiles with organometallic compounds, arylation via C-H bond cleavage, Pd/norbornene-catalyzed aromatic functionalizations, three-component cyclizations of allenes, use of N-heterocyclic carbenes as ligands, asymmetric reactions catalyzed by Pd(II) compounds such as Lewis acids, cycloadditions of arynes and alkynes, and nucleophilic attack by Pd species are surveyed in detail by researchers who have made important contributions to these fields. The book addresses graduate students majoring in organic synthesis and researchers in academic and industrial institutes.