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Author: Peter A. Jacobi Publisher: John Wiley & Sons ISBN: 1119417686 Category : Science Languages : en Pages : 306
Book Description
A unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals Heterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. Introductory Heterocyclic Chemistry offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; π-deficient heterocycles; π-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. Presents a conversational approach to a fundamental topic in organic chemistry teaching Offers a unique look at this core organic chemistry topic via important naturally occurring and/or biologically active heterocycles Based on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses Clear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry Introductory Heterocyclic Chemistry is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology.
Author: Peter A. Jacobi Publisher: John Wiley & Sons ISBN: 1119417686 Category : Science Languages : en Pages : 306
Book Description
A unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals Heterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. Introductory Heterocyclic Chemistry offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; π-deficient heterocycles; π-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. Presents a conversational approach to a fundamental topic in organic chemistry teaching Offers a unique look at this core organic chemistry topic via important naturally occurring and/or biologically active heterocycles Based on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses Clear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry Introductory Heterocyclic Chemistry is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology.
Author: Alan R. Katritzky Publisher: Elsevier ISBN: 1483274519 Category : Science Languages : en Pages : 199
Book Description
The Principles of Heterocyclic Chemistry presents a unified account of fundamental heterocyclic chemistry with the emphasis placed on the correlations between the methods of preparation and the properties of the various ring systems. This book opens with an introductory chapter that discussesfundamental concepts of the electronic theory of organic chemistry and the relationship of heterocyclic and carbocyclic aromatic compounds. This is followed by separate chapters on the chemistry of the six-membered ring compounds containing one or more heteroatoms, five-membered ring compounds, three- and four-membered rings, and the physical properties of representative heterocyclic compounds. Each chapter begins with introductory section that surveys the various ring types, gives the systems of nomenclature and numbering, and mentions a few important natural and synthetic compounds. Syntheses starting from aliphatic and carbocyclic compounds are then given. The preparation of one heterocyclic compound from another is considered as a reaction of the starting material. The reactions of aromatic and non-aromatic compounds are discussed separately. This book contains the essential heterocyclic chemistry required by an Undergraduate or Graduate student for his course-work, and it is hoped that it will be found stimulating by many a more senior teacher and researcher.
Author: Jie Jack Li Publisher: John Wiley & Sons ISBN: 1118354435 Category : Science Languages : en Pages : 688
Book Description
Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
Author: Shu Kobayashi Publisher: John Wiley & Sons ISBN: 9783527301591 Category : Science Languages : en Pages : 354
Book Description
During the miners' strike in the 1980s, a worker is killed in the striking coalfields of Wales. Some months later, a government minister thought to be connected with the death is also shot. Lewis Redfern—once a radical but now a political analyst and journalist—pursues the sniper, a lonely hunt that leads him through an imbroglio of civil service leaks to a secret organization: a source of insurrection far more powerful than anyone could have suspected known as the Volunteers. In this fast-paced narrative of espionage and intrigue, Redfern, through his obsessive pursuit of justice, finally encounters the truth about himself as the novel discusses the conflict between moral choice and political loyalty.
Author: Alan R. Katritzky Publisher: Elsevier ISBN: 1483293424 Category : Science Languages : en Pages : 568
Book Description
Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.
Author: Joseph E. Rice Publisher: Academic Press ISBN: 0128008326 Category : Science Languages : en Pages : 219
Book Description
Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. - Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding - Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more - Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material
Author: Jie Jack Li Publisher: John Wiley & Sons ISBN: 0470872209 Category : Science Languages : en Pages : 774
Book Description
This book continues the well-established and authoritative series on name reactions in organic chemistry by focusing on name reactions on ring formation. Ring formating reactions have found widespread applicability in traditional organic synthesis, medicinal/pharmaceuticals, agricultural, fine chemicals, and of late, especially in polymer science.
Author: W. Carruthers Publisher: Elsevier ISBN: 008091232X Category : Science Languages : en Pages : 382
Book Description
Demonstrates the wide scope of cycloaddition reactions, including the Diels-Alder reaction, the ene reaction, 1,3-dipolar cycloadditions and [2+2] cycloadditions in organic synthesis. The author, a leading exponent of the subject, illustrates the ways in which they can be employed in the synthesis of a wide range of carbocyclic and heterocyclic compounds, including a variety of natural products of various types. Special attention is given to intramolecular reactions, which often provide a rapid and efficient route to polycyclic compounds, and to the stereochemistry of the reactions, including recent and developing work on enantioselective synthesis.
Author: Peter A. Jacobi
Author: Victor von Richter
Author: Peter A. Jacobi
Author: Alan R. Katritzky
Author: Jie Jack Li
Author: David St. Clair Black
Author: Shu Kobayashi
Author: Alan R. Katritzky
Author: Joseph E. Rice
Author: Jie Jack Li
Author: W. Carruthers