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Author: G. Bradley Schaefer Publisher: McGraw Hill Professional ISBN: 0071819282 Category : Medical Languages : en Pages : 385
Book Description
A complete introductory text on how to integrate basic genetic principles into the practice of clinical medicine Medical Genetics is the first text to focus on the everyday application of genetic assessment and its diagnostic, therapeutic, and preventive implications in clinical practice. It is intended to be a text that you can use throughout medical school and refer back to when questions arise during residency and, eventually, practice. Medical Genetics is written as a narrative where each chapter builds upon the foundation laid by previous ones. Chapters can also be used as stand-alone learning aids for specific topics. Taken as a whole, this timely book delivers a complete overview of genetics in medicine. You will find in-depth, expert coverage of such key topics as: The structure and function of genes Cytogenetics Mendelian inheritance Mutations Genetic testing and screening Genetic therapies Disorders of organelles Key genetic diseases, disorders, and syndromes Each chapter of Medical Genetics is logically organized into three sections: Background and Systems – Includes the basic genetic principles needed to understand the medical application Medical Genetics – Contains all the pertinent information necessary to build a strong knowledge base for being successful on every step of the USMLE Case Study Application – Incorporates case study examples to illustrate how basic principles apply to real-world patent care Today, with every component of health care delivery requiring a working knowledge of core genetic principles, Medical Genetics is a true must-read for every clinician.
Author: G. Bradley Schaefer Publisher: McGraw Hill Professional ISBN: 0071819282 Category : Medical Languages : en Pages : 385
Book Description
A complete introductory text on how to integrate basic genetic principles into the practice of clinical medicine Medical Genetics is the first text to focus on the everyday application of genetic assessment and its diagnostic, therapeutic, and preventive implications in clinical practice. It is intended to be a text that you can use throughout medical school and refer back to when questions arise during residency and, eventually, practice. Medical Genetics is written as a narrative where each chapter builds upon the foundation laid by previous ones. Chapters can also be used as stand-alone learning aids for specific topics. Taken as a whole, this timely book delivers a complete overview of genetics in medicine. You will find in-depth, expert coverage of such key topics as: The structure and function of genes Cytogenetics Mendelian inheritance Mutations Genetic testing and screening Genetic therapies Disorders of organelles Key genetic diseases, disorders, and syndromes Each chapter of Medical Genetics is logically organized into three sections: Background and Systems – Includes the basic genetic principles needed to understand the medical application Medical Genetics – Contains all the pertinent information necessary to build a strong knowledge base for being successful on every step of the USMLE Case Study Application – Incorporates case study examples to illustrate how basic principles apply to real-world patent care Today, with every component of health care delivery requiring a working knowledge of core genetic principles, Medical Genetics is a true must-read for every clinician.
Author: Lee Know Publisher: Chelsea Green Publishing ISBN: 1603587675 Category : Health & Fitness Languages : en Pages : 274
Book Description
With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.
Author: Lawrence H. Lash Publisher: Elsevier ISBN: 1483218619 Category : Science Languages : en Pages : 527
Book Description
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author: Derek A. Applegarth Publisher: CRC Press ISBN: 9780412549106 Category : Medical Languages : en Pages : 480
Book Description
Many inherited diseases are due to enzyme deficiencies located within the subcellular `organelles'. Such diseases can have devastating effects such as mental impairment, muscle wasting or retarded growth. Early and correct diagnosis is vital so that appropriate care can be given. This book will be the first to provide a comprehensive coverage of these conditions with emphasis both on clinical and laboratory recognition. This unique book provides a compendium of how to recognize organelle diseases and how to confirm their diagnosis using clinical, medical and laboratory procedures. The chapters on basic biology explain the basic function of each organelle and explains how each group of diseases may be caused.
Author: Stine Helene Falsig Pedersen Publisher: Springer Nature ISBN: 3031225953 Category : Science Languages : en Pages : 278
Book Description
This book sheds light on how dysregulated organelle functions contribute to the pathology and progression of human diseases. To offer a broad perspective, they discuss basic, translational, and clinical aspects across scales, from molecules to cells, tissues and organisms. Rather than providing a comprehensive introduction to the field, the authors focus on recent advances in organelle research, with each chapter inviting readers to consider today’s key questions in the respective field. This book reviews the endoplasmic reticulum, Golgi Appartus, Lysosomes and other membrane-enclosed organelles, demonstrating how their dysregulated function contributes to various pathologies. The chapters not only offer a platform for new perspectives but also stimulate further investigations. Given the translational nature of this subject, this book is a valuable resource for physiologists and clinicians alike. Chapter "Lipid Droplets in Cancer" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Chris Mullins Publisher: Springer Science & Business Media ISBN: 0387268677 Category : Medical Languages : en Pages : 191
Book Description
The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.
Author: Frederick R. Maxfield Publisher: John Wiley & Sons ISBN: 1118978315 Category : Medical Languages : en Pages : 586
Book Description
Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development
Author: G. Bradley Schaefer
Author: G. Bradley Schaefer
Author: Lee Know
Author: Lawrence H. Lash
Author: Derek A. Applegarth
Author: 
Author: J. Gordon Betts
Author: Stine Helene Falsig Pedersen
Author: Norman F. Cheville
Author: Chris Mullins
Author: Frederick R. Maxfield