Nucleophilic Aromatic Displacements in Substituted Pyridine N-oxides PDF Download

Author: R. M. Johnson
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Oleg N. Chupakhin
Publisher: Academic Press
ISBN: 0323140599
Category : Science
Languages : en
Pages : 378

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Nucleophilic aromatic substitution in carbo- and heteroaromatic systems is a subject of considerable interest to chemists. This book uniquely addresses the systematic analysis of a vast range of nucleophilic substitutions of aromatic hydrogen. - Nucleophilic displacement of hydrogen (the S N/H reactions) in pi-deficient aromatics, such as nitroarenes, arene-metal complexes, and the like - Nucleophilic displacement of hydrogen in heterocyclic substrates such as pyridines, their aza and benzo analogs, pyrylium and thiapyrylium cations, and other heterocycles - Mechanisms for the S N/H reactions (S N/H(AE), vicarious nucleophilic substitutions, and radical S N/H substitutions

Author: Valery Charushin
Publisher: Springer
ISBN: 3319070193
Category : Science
Languages : en
Pages : 289

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The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.

Author: Francois Terrier
Publisher: John Wiley & Sons
ISBN: 3527656162
Category : Science
Languages : en
Pages : 488

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This book provides a comprehensive overview of nucleophilic aromatic substitutions, focusing on the mechanistic and synthetic features that govern these reactions. The first chapter presents a detailed mechanistic analysis of the factors determining the feasibility of SNAr substitutions, providing decisive information to predict regioselectivity of many reactions and to define the conditions for concerted SNAr processes. Reflecting the key role played by these species as intermediates in most SNAr reactions, chapter 2 then discusses the chemistry of anionic sigma-complexes. Chapter 3 describes the concept of superelectrophilicity in SNAr substitutions, as it has recently emerged from the reactivity of strongly electron-deficient aromatic and heteroaromatic structures. The numerous synthetic applications are considered in depth in the chapters 4 and 5 that follow on intermolecular and intramolecular nucleophilic aromatic substitutions. Then, chapter 6 focuses on substitutions proceeding formally through displacement of a hydride ion, a hot topic in the field. The final chapter brings together concise yet comprehensive discussions surrounding SNAr photosubstitutions, radical substitutions, and ANRORC substitutions. Authored by a highly respected chemist who has contributed greatly to the field over the past two decades, this is a valuable information source for all organic chemists working in academia or the pharmaceutical and agrochemical industries.

Author: François Terrier
Publisher: Wiley-VCH
ISBN:
Category : Science
Languages : en
Pages : 480

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Author: J. A. Joule
Publisher: Springer
ISBN:
Category : Science
Languages : en
Pages : 556

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1. Structures and main physical properties of aromatic heterocycles 1; 2. Reactivity of aromatic heterocycles 18; 3. synthesis of aromatic heterocycles 56; 4. Typical reactivity of pyridines, quinolines, and isoquinolines 64; 5. Pyridines: reactions and synthesis 72; 6. Quinolines and isoquinolines: reactions and synthesis 120; 7. Typical reactivity of pyrylium and benzopyrylium ions, pyrones and benzopyrones 146; 8. Pyryliums, 2- and 4-pyrones: reactions and synthesis 148; 9. Benzopyryliums and benzopyrones: reactions and synthesis 166; 10. Typical reactivity of the diazines: pyridazine, pyrimidine and pyrazine 185; 11. the diazines: pyridazine, pyrimidine and pyrazine: reactions and synthesis 189; 12. Typical reactivity of pyrroles, thiophenes and furans 225; 13. Pyrroles: reactions and synthesis 229; 14. Thiophenes: reactions and synthesis 259; 15. Furans: reactions and synthesis 278; 16. Reactivity of indoles, benzo[b]thiophenes, benzo[b]furans, isoindoles, benzo[c]thiophenes and isobenzofurans 301; 17. Indoles: reactions and synthesis 305; 18. Benzo[b]thiophenes and benzo[b]furans: reactions and synthesis 350; 19. Isoindoles, benzo[c]thiophenes and isobenzofurans: reactions and synthesis 360; 20. Typical reactivity of 1,3- and 1,2-azoles 367; 21. 1,3-Azoles: imidazoles, thiazoles, and oxazoles: reactions and synthesis 370; 22. 1,2-Azoles: pyrazoles, isothiazoles and isoxazoles: reactions and synthesis 394; 23. Purines: reactions and synthesis 409; 24. Heterocycles containing a ring-junction nitrogen 434; 25. Heterocycles containing more than two hetero atoms 447; 26. Saturated and partially unsaturated heterocyclic compounds: reactions and synthesis 463; 27. Appendix: answers to exercises 479.

Author: Oleg V. Larionov
Publisher: Springer
ISBN: 3319606875
Category : Science
Languages : en
Pages : 163

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Book Description
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Author: Chemical Society (Great Britain)
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 1042

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Author: Peter A. Jacobi
Publisher: John Wiley & Sons
ISBN: 1119417678
Category : Science
Languages : en
Pages : 273

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A unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals Heterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. Introductory Heterocyclic Chemistry offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; π-deficient heterocycles; π-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. Presents a conversational approach to a fundamental topic in organic chemistry teaching Offers a unique look at this core organic chemistry topic via important naturally occurring and/or biologically active heterocycles Based on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses Clear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry Introductory Heterocyclic Chemistry is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology.

Author: A. C. Knipe
Publisher: John Wiley & Sons
ISBN: 1118941799
Category : Science
Languages : en
Pages : 1023

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Organic Reaction Mechanisms 2014, the 50th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2014. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. This volume includes a 5-year cumulative index.