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Book Description
De nouvelles techniques de traitement des spectres de Résonance Magnétique Nucléaire à deux dimensions (RMN-2D) sont présentées, en vue d’aider à la reconstitution de la structure tridimensionnelle des molécules. L’expérience de NOESY-2D étant l’expérience clef dans la détermination des conformations, les problèmes posés par l’interprétation quantitative de l’Effet Nucléaire Overhauser (NOE), sont présentées en détail. Une méthode est proposée pour la détection et l’intégration automatique des pics dans les cartes de RMN-2D. Elle est utilisée dans la détermination de distances internucléaires à partir des cartes NOE, y compris en cas de présence de cohérences zéro-quanta. Les principes de la confrontation entre les données RMN, et celles de méthode de calculs théoriques de conformations, sont exposés. Un exemple d’application est donné par la détermination de la géométrie d’un oligo-nucléotide platiné. Cet exemple constitue un modèle dans l’étude de l’interaction entre l’ADN et une drogue antitumorale : le cisdiamine-dichloro-platine (II). Par ailleurs, l’auteur propose un algorithme de phasage automatique, et une méthode de déconvolution dans le cadre général de la reconstruction inverse des spectres par Maximum Entropie. Ces techniques devraient aider le spectroscopiste dans le traitement et l’interprétation de spectres complexes de macro-molécules.
Book Description
De nouvelles techniques de traitement des spectres de Résonance Magnétique Nucléaire à deux dimensions (RMN-2D) sont présentées, en vue d’aider à la reconstitution de la structure tridimensionnelle des molécules. L’expérience de NOESY-2D étant l’expérience clef dans la détermination des conformations, les problèmes posés par l’interprétation quantitative de l’Effet Nucléaire Overhauser (NOE), sont présentées en détail. Une méthode est proposée pour la détection et l’intégration automatique des pics dans les cartes de RMN-2D. Elle est utilisée dans la détermination de distances internucléaires à partir des cartes NOE, y compris en cas de présence de cohérences zéro-quanta. Les principes de la confrontation entre les données RMN, et celles de méthode de calculs théoriques de conformations, sont exposés. Un exemple d’application est donné par la détermination de la géométrie d’un oligo-nucléotide platiné. Cet exemple constitue un modèle dans l’étude de l’interaction entre l’ADN et une drogue antitumorale : le cisdiamine-dichloro-platine (II). Par ailleurs, l’auteur propose un algorithme de phasage automatique, et une méthode de déconvolution dans le cadre général de la reconstruction inverse des spectres par Maximum Entropie. Ces techniques devraient aider le spectroscopiste dans le traitement et l’interprétation de spectres complexes de macro-molécules.
Author: Helena Dodziuk Publisher: John Wiley & Sons ISBN: 3527608443 Category : Science Languages : en Pages : 507
Book Description
Offering comprehensive and up-to-date know-how in one compact book, an experienced editor and top authors cover every aspect of these important molecules from molecular recognition to cyclodextrins as enzyme models. Chapters include reactivity and chemistry, chromatography, X-ray, NMR plus other physicochemical methods, as well as model calculations, rotaxane and catenane structures, and applications in the pharmaceutical industry. The book also discusses other applications such as in the cosmetics, toiletries, textile and wrapping industries, agrochemistry, electrochemical sensors, and devices. A must for everyone working with these substances.
Author: Guillaume Lecointre Publisher: Harvard University Press ISBN: 9780674021839 Category : Science Languages : en Pages : 568
Book Description
Did you know that you are more closely related to a mushroom than to a daisy? That dinosaurs are still among us? That the terms "fish" and "invertebrates" do not indicate scientific groupings? All this is the result of major changes in classification. This book diagrams the tree of life according to the most recent methods of this system.
Author: Graham A. Webb Publisher: Springer Science & Business Media ISBN: 1402039107 Category : Technology & Engineering Languages : en Pages : 1889
Book Description
A comprehensive collection of the applications of Nuclear Magnetic Resonance (NMR), Magnetic Resonance Imaging (MRI) and Electron-Spin Resonance (ESR). Covers the wide ranging disciplines in which these techniques are used: * Chemistry; * Biological Sciences; * Pharmaceutical Sciences; * Medical uses; * Marine Science; * Materials Science; * Food Science. Illustrates many techniques through the applications described, e.g.: * High resolution solid and liquid state NMR; * Low resolution NMR, especially important in food science; * Solution State NMR, especially important in pharmaceutical sciences; * Magnetic Resonance Imaging, especially important for medical uses; * Electron Spin Resonance, especially important for spin-labelling in food, marine and medical studies.
Author: Edward R. Landa Publisher: Springer Science & Business Media ISBN: 9048129605 Category : Technology & Engineering Languages : en Pages : 524
Book Description
SOIL: beneath our feet / food and fiber / ashes to ashes, dust to dust / dirt!Soil has been called the final frontier of environmental research. The critical role of soil in biogeochemical processes is tied to its properties and place—porous, structured, and spatially variable, it serves as a conduit, buffer, and transformer of water, solutes and gases. Yet what is complex, life-giving, and sacred to some, is ordinary, even ugly, to others. This is the enigma that is soil. Soil and Culture explores the perception of soil in ancient, traditional, and modern societies. It looks at the visual arts (painting, textiles, sculpture, architecture, film, comics and stamps), prose & poetry, religion, philosophy, anthropology, archaeology, wine production, health & diet, and disease & warfare. Soil and Culture explores high culture and popular culture—from the paintings of Hieronymus Bosch to the films of Steve McQueen. It looks at ancient societies and contemporary artists. Contributors from a variety of disciplines delve into the mind of Carl Jung and the bellies of soil eaters, and explore Chinese paintings, African mud cloths, Mayan rituals, Japanese films, French comic strips, and Russian poetry.
Author: Francesca Casadio Publisher: Springer ISBN: 3319906178 Category : Technology & Engineering Languages : en Pages : 433
Book Description
This go-to reference work surveys the current state of knowledge in the field of metal soap-related degradation phenomena in art works. It contains detailed descriptions and images of the different phenomena and addresses the practical aspects of soap formation, preventive conservation, and treatment. The occurrence of metal soaps is one of the defining issues in the conservation of painted surfaces, and one that presently leaves innumerable open questions. It is estimated that around 70% of paintings in museum collections are affected by some form of metal soap-related degradation. In recent years, significant advances have been made in the detection and characterization of these compounds through interdisciplinary approaches including conventional spectroscopy and microscopy as well as emerging synchrotron-based techniques. This book for the first time captures a panoramic overview of the state of knowledge of metal soaps related to both scientific analysis and implications for conservation and treatment. It also critically examines open questions. The book is accessible to audiences with varied backgrounds (e.g. conservators, students of conservation science) while simultaneously presenting the technical details indispensable for academics and researchers active in this field.
Author: Ursula Jakob Publisher: Springer Science & Business Media ISBN: 9400757875 Category : Science Languages : en Pages : 488
Book Description
Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.
Author: Francisco Carrasco Publisher: Springer Science & Business Media ISBN: 3642124860 Category : Science Languages : en Pages : 519
Book Description
The Malaga Symposia Series provides an international forum for scientific debate on the progress made in research into karst environments. The 2010 meeting of the 4th International ISKA presents 80 papers in four key areas: karst hydrogeology and investigations, karst landscape and ecosystems, human interaction with karst environments, and engineering geology in karst areas. This book will be a useful edition to the libraries of consultants, scientists, lecturers, and policy makers concerned with the special issues of karst terrains.
Author: Marco Picichè Publisher: Springer Science & Business Media ISBN: 8847024005 Category : Medical Languages : en Pages : 355
Book Description
The book provides a clear overview of the various research stages of cardiac surgery, interventional cardiology, and cardiac anesthesia. It also deals with recent advances in minimally invasive surgery, robotic surgery, and many other innovations introduced in this field. However, aim of this volume is not only to describe the evolution of the discipline, but also to give the occasion of revisiting old and forgotten ideas that could be used successfully also nowadays if supported by modern technologies. With contributions by renowned international experts, the volume will be a very useful tool for students, residents, cardiac surgery and anesthesia professionals, cardiologists, biomedical engineers, and researchers.
Author: Véronique Stoven
Author: Véronique Stoven
Author: Helena Dodziuk
Author: Ion I. Inculet
Author: Guillaume Lecointre
Author: Graham A. Webb
Author: Edward R. Landa
Author: Francesca Casadio
Author: Ursula Jakob
Author: Francisco Carrasco
Author: Marco Picichè