Author: Arthur Mikhno Publisher: ISBN: Category : Languages : en Pages :
Book Description
Recovery of signal from blood vessels and integration with the non-invasive framework is demonstrated. We also show general applicability of this technique for visualization and signal recovery from the raphe, a sub-resolution cluster of nuclei in the brain that were previously not detectible with standard techniques. Our framework can be generalizable to all classes of radioligands, independent of their kinetics and distribution within body. Work presented in this thesis will allow the PET scientific and clinical community to advance towards the ultimate goal of making PET cost-effective and to enable new clinical use cases.
Author: Peter Oehr Publisher: Springer Science & Business Media ISBN: 3642188036 Category : Medical Languages : en Pages : 378
Book Description
PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion, the book offers instructive information and overviews of the basic principles of PET and PET-CT as well as the routine clinical PET scanning procedures for all important oncological indications. It is designed to serve as a reference work for specialists in nuclear medicine and radiology (including therapy planning) and for oncologists. It also provides student and physicians in other medical specialities with a general introduction to the effective integration of this modern technique into routine clinical diagnostics. Above all, this volume illustrates the importance of PET and PET-CT in comparison with other imaging techniques.
Author: Xiujuan Zheng Publisher: ISBN: Category : Tomography, Emission Languages : en Pages : 152
Book Description
Furthermore, the frequent invasive arterial blood sampling to obtain input function poses many challenges and inconvenience for tracer kinetic modeling with dynamic PET imaging. Non-invasive approaches were proposed to address this issue. A simple non-invasive quantification method based on Patlak graphic analysis (PGA) that uses a reference region to obtain the relative influx rate without an input function has recently been proposed. This non-invasive Patlak (nPGA) method was extended to whole-body FDG-PET studies and systematically investigated using a set of mouse studies and computer simulations. In the mouse studies, a high linearity of relative influx rates was observed between the nPGA and PGA for most pairs of reference and target regions, when an appropriate underlying kinetic model was used. The simulation results demonstrated that the accuracy of the nPGA method was similar to that of the PGA method, with a higher reliability for most pairs of reference and target regions. The results proved that the nPGA method could provide a non-invasive and indirect way of quantifying the FDG kinetics in the tissues where the k4 and vascular effect were negligible. The automatic non-invasive approach can further facilitate the analysis of dynamic PET imaging. A novel hybrid clustering method (HCM) was proposed to objectively delineate the regions of interest (ROIs) in dynamic PET images for the automatic estimation of image-derived input function (IDIF) and was demonstrated the application to the mouse FDG-PET studies. The results showed that the HCM achieved accurate ROIs delineation in both computer simulations and experimental mouse studies. In the mouse studies the predicted IDIF had a high correlation with the gold standard, the PTAC derived from invasive blood sampling. The results indicate that the proposed HCM has a great potential in ROI delineation for automatic estimation of IDIF in dynamic FDG-PET studies. In summary, this thesis has significantly contributed to the improvement of several critical quantification approaches for preclinical small-animal studies and clinical patient examinations.
Author: Vincent Turgeon Publisher: ISBN: Category : Languages : en Pages :
Book Description
"Positron emission tomography (PET) is a nuclear medicine imaging modality used to acquire functional images. When several images are acquired at different time frames, the scan is considered dynamic, and the result is a movie showing where and how the imaging agents accumulated inside the patient. Dynamic PET is a valuable tool for staging and diagnosing of cancer, cerebral injuries and neurological disorders. To perform quantitative analysis on dynamic images, the imaging agent concentration in the arteries, known as the arterial input function (AIF), is required. The clinical standard to acquire the AIF is through invasive blood sampling. Unfortunately, the invasive withdrawal of arterial blood causes a significant discomfort to the patient and there is a risk of exposing the medical personnel to large amount of radiation. Since none of the alternative technologies and methods developed in the past 30 years were able to replace the manual blood sampling, dynamic PET imaging is restricted to centers with large financial and technical resources. We have developed a non-invasive and cost effective radiation detector based on plastic scintillating fibers to detect the positrons emerging from the patient’s wrist arteries after the injection of the radiotracers and monitor the AIF. The first aim of this thesis was to characterize the attenuation length of the detector with 137-Cs and ultraviolet (UV) sources. The attenuation length obtained with 137-Cs agrees with the one provided by the scintillating fiber’s manufacturer, but the measurement with UV source over-estimates it. The second aim was to investigate if the bending of the fiber in loops would cause important light losses. With the 137-Cs source, the losses were smaller than the measurement uncertainty. The final aim was to test the detector with 18-F and 11-C. The detector response to a pulse of radioactivity is better for the 11-C, due to its longer positron range. The detector was also able to accurately measure the decay of 11-C from 3.02 MBq/ml to 0.17 MBq/ml. These preliminary measurements demonstrate that plastic scintillating fibers are a suitable detection material to develop a non-invasive detector that could potentially replace invasive blood sampling as the clinical method to determine the AIF in dynamic PET imaging"--
Author: Michael S. Hofman Publisher: Springer ISBN: 3319547410 Category : Medical Languages : en Pages : 73
Book Description
This pocket book provides up-to-date guidance on the use of PET/CT in patients with melanoma, which is of rapidly growing importance due to the emergence of immunotherapy. The role of PET/CT in diagnostic workup, staging, treatment selection, prognostication, and follow-up is clearly explained. Imaging features are described and illustrated with the aid of a series of teaching cases, and attention is drawn to normal variants, artifacts, and pitfalls. Readers will also find explanation of the relation of the clinical and pathological background to imaging and the value of PET/CT compared with conventional radiological imaging. The book is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging (compiled under the auspices of the British Nuclear Medicine Society) and will be an excellent asset for referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings.
Author: Giuliano Mariani Publisher: Springer Science & Business Media ISBN: 0387383271 Category : Medical Languages : en Pages : 319
Book Description
This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.
Author: Eric Nofzinger Publisher: Cambridge University Press ISBN: 1107018633 Category : Medical Languages : en Pages : 445
Book Description
An up-to-date, superbly illustrated practical guide to the effective use of neuroimaging in the patient with sleep disorders. The only book to date to provide comprehensive coverage of this topic. A must for all healthcare workers interested in understanding the causes, consequences and treatment of sleep disorders.
Author: Jose Luis Zamorano Publisher: OUP Oxford ISBN: 0191008435 Category : Medical Languages : en Pages : 661
Book Description
A definitive resource, The ESC Textbook of Cardiovascular Imaging, second edition provides extensive coverage of all cardiovascular imaging modalities. Produced in collaboration with the European Association of Cardiovascular Imaging with contributions from specialists across the globe and edited by a distinguished team of experts, it is a 'state of the art' clinically-orientated imaging reference. Now fully revised and updated with the latest imaging techniques and technology and covering even more conditions than before, it not only discusses the principles of individual modalities but also clearly demonstrates the added value each technique can bring to the treatment of all cardiac diseases. Richly illustrated with colour figures, images, and tables and using a wealth of newly available evidence to link theory to practice, it demonstrates how these techniques can be used in the diagnosis of a range of cardiovascular diseases. Learning how to apply them in practice is made easy with free access to videos and imaging loops online along with the full text so that it is always available, even when on the move. Impressive in scope, The ESC Textbook of Cardiovascular Imaging contains information on cutting-edge technical developments in echocardiography, CT, CMR and hybrid imaging and well imaging's current role in cardiac interventions, such as identifying cardiac structures, helping to guide procedures and exclude possible complications. The application of imaging modalities in conditions such as valvular and coronary heart disease, heart failure, cardiomyopathies, peri-myocardioal disease, adult congenital heart disease and aortic disease, is also extensively considered. From discussion on improved imaging techniques and advances in technology, to guidance and explanation of key practices and theories, this new edition of The ESC Textbook of Cardiovascular Imaging is the ideal reference guide for cardiologists and radiologists alike. This print edition of The ESC Textbook of Cardiovascular Imaging comes with access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables.
Author: Dragana Sobic Saranovic Publisher: Springer Nature ISBN: 3030470091 Category : Medical Languages : en Pages : 159
Book Description
This book covers both the science of PET/CT imaging in tuberculosis and the impact that this technique can have on disease management through the provision of high-quality evidence regarding function and structure. The scientific principles of PET/CT, the radiopharmaceuticals used in the context of tuberculosis (FDG and non-FDG tracers), patient preparation, and imaging protocols are fully explained. Imaging findings obtained in different settings, including pulmonary and extrapulmonary tuberculosis, tuberculosis and HIV co-infection, and evaluation of response to antituberculous therapy, are described with the aid of many high-quality illustrations. Attention is drawn to mimics of tuberculosis, pitfalls, and limitations. The book will be an excellent asset for referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings.
Author: Stephan G. Nekolla Publisher: ISBN: 9783030831684 Category : Languages : en Pages : 0
Book Description
This clinically oriented book provides an up-to-date review on the various hybrid imaging modalities that may be employed for the purpose of cardiac imaging. After discussion of generic aspects of hybrid imaging, SPECT/CT, PET/CT, and PET/MRI are each considered in depth. In addition, information is provided on upcoming technologies, such as dedicated so-called fast cardiac cameras (CZT detector technology) and novel probes and radiotracers. A wide variety of topics are addressed, including important technological aspects, possible applications, imaging protocols, peculiarities of the available modalities, radiation exposure, and dose reduction. Last but not least, an estimation of the cost efficiency of dedicated and hybrid imaging devices in cardiology is provided and possible scenarios with respect to health care economics are envisioned. Hybrid Cardiac Imaging will be of particular value for nuclear medicine specialists, cardiologists, and radiologists and will also be of interest to medical physicists, medical technicians, and cardiothoracic surgeons. .
Author: Arthur Mikhno
Author: Peter Oehr
Author: Xiujuan Zheng
Author: Vincent Turgeon
Author: Michael S. Hofman
Author: Giuliano Mariani
Author: Eric Nofzinger
Author: Jose Luis Zamorano
Author: Dragana Sobic Saranovic
Author: Stephan G. Nekolla