Nitric Oxide and Cytochrome P450 Signaling in Experimental Pulmonary Hypertension PDF Download

Author: Peter Pokreisz
Publisher: Leuven University Press
ISBN: 9789058675668
Category :
Languages : en
Pages : 136

View

Book Description

Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
ISBN: 1615041230
Category : Science
Languages : en
Pages : 309

View

Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Author: An Van Den Bergh
Publisher: Leuven University Press
ISBN: 9789058675811
Category : Medical
Languages : en
Pages : 152

View

Book Description

Author: Ronald D. Miller
Publisher: Elsevier Health Sciences
ISBN: 1437720617
Category : Medical
Languages : en
Pages : 3220

View

Book Description
From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. It is the go-to reference for masterful guidance on the technical, scientific, and clinical challenges you face. Now new chapters, new authors, meticulous updates, an increased international presence, and a new full-color design ensure that the 7th edition continues the tradition of excellence that you depend on. Covers the full scope of contemporary anesthesia practice. Offers step-by-step instructions for patient management and an in-depth analysis of ancillary responsibilities and problems. Incorporates ‘Key Points’ boxes in every chapter that highlight important concepts. Extends the breadth of international coverage with contributions from prominent anesthesiologists from all over the world, including China, India, and Sweden. Features 30 new authors and 13 new chapters such as Sleep, Memory and Consciousness; Perioperative Cognitive Dysfunction; Ultrasound Guidance for Regional Anesthesia; Anesthesia for Correction of Cardiac Arrhythmias; Anesthesia for Bariatric Surgery; Prehospital Emergency and Trauma Care; Critical Care Protocols; Neurocritical Care; and Renal Replacement Therapy. Dedicates an entire section to pediatric anesthesia, to help you address the unique needs of pediatric patients. Presents a new full-color design -- complete with more than 1,500 full-color illustrations -- for enhanced visual guidance.

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 2160

View

Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Author: Ilse Vastiau
Publisher: Leuven University Press
ISBN: 9789058675798
Category : Science
Languages : en
Pages : 110

View

Book Description

Author: Anna-Pia Papageorgiou
Publisher: Leuven University Press
ISBN: 9789058675828
Category : Medical
Languages : en
Pages : 166

View

Book Description

Author: Sofie Janssen
Publisher: Leuven University Press
ISBN: 9789058675729
Category : Medical
Languages : en
Pages : 162

View

Book Description

Author: Maarten Leyssen
Publisher: Leuven University Press
ISBN: 9789058675682
Category : Axons
Languages : en
Pages : 142

View

Book Description

Author: Harald H. H. W. Schmidt
Publisher: Springer Nature
ISBN: 3030685101
Category : Medical
Languages : en
Pages : 425

View

Book Description
Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.