Nitric Acid in Experimental Sepsis PDF Download

Author: Pieter Lee Dahm
Publisher:
ISBN:
Category : Nitric oxide
Languages : en
Pages : 152

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Author: Robert D. Stevens
Publisher: Cambridge University Press
ISBN: 1107434424
Category : Medical
Languages : en
Pages : 457

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Book Description
Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.

Author: René Holzheimer
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 880

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Author: Lawrence H. Lash
Publisher: Elsevier
ISBN: 1483218619
Category : Science
Languages : en
Pages : 527

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Book Description
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Author: Michael R. Pinsky
Publisher: Springer Science & Business Media
ISBN: 3540373632
Category : Medical
Languages : en
Pages : 367

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Book Description
Te practice of intensive care medicine is at the very forefront of titration of treatment andmonitoringresponse. Te substrateofthiscareisthe criticallyill patientwho,by defnition, is at the limits of his or her physiologic reserve. Such patients need immediate, aggressive but balanced life-altering interventions to minimize the detrimental aspects of acute illness and hasten recovery. Treatmentdecisionsandresponsetotherapyareusually assessed by measures of physiologic function, such as assessed by cardio-respiratory monitoring. However, how one uses such information is ofen unclear and rarely supported by prospective clinical trials. In reality, the bedside clinician is forced to rely primarily on physiologic principles in determining the best treatments and response to therapy. However, the physiologic foundation present in practicing physicians is uneven and occasionally supported more by habit or prior training than science. A series of short papers published in Intensive Care Medicine since 2002 under the heading Physiologic Notes attempts to capture the essence of the physiologic perspectives that underpin both our understanding of disease and response to therapy. Tis present volume combines the complete list of these Physiologic Notes up until July 2006 with the ass o cia t ed r e vie w a r tic les o v er t h e s a m e in t er val t ha t a ls o addr ess e d t hes e cen tral issues.

Author: W. Joost Wiersinga
Publisher: Springer
ISBN: 3319735063
Category : Medical
Languages : en
Pages : 264

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Book Description
This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.

Author: Jack Lancaster Jr.
Publisher: Elsevier
ISBN: 0080537545
Category : Science
Languages : en
Pages : 373

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Book Description
This unique sourcebook serves as a comprehensive reference, bridging the well-established chemistry of nitric oxide and the new and exciting role of nitric oxide as an effector and signaling molecule in numerous biological systems. Nitric Oxide: Principles and Actions relates the chemical properties of the molecule to its possible effects on biological systems, under both normal physiological and pathophysiological conditions. Combining the chemistry and analysis of nitric oxide with newer studies of the relevance of the molecule gives this book a long life, making it extremely useful to researchers in a number of areas. - Provides a much needed compilation of what is known about nitric oxide and its properties - Enables researchers to understand the importance and use of nitric oxide in systems of study - Covers an area of tremendous growth in research - Provides the first collection of the roles of nitric oxide in microbial and mammalian systems and as a probe of metalloenzymes - Presents the historically important role of nitric oxide in food preservation

Author: Louis J. Ignarro
Publisher: Academic Press
ISBN: 0080525032
Category : Medical
Languages : en
Pages : 1023

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Book Description
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. - Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide - Authored by world experts on nitric oxide - Includes an overview of basic principles of biology and chemical biology - Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense

Author: John Barker
Publisher: Routledge
ISBN: 0429523432
Category : Education
Languages : en
Pages : 513

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Book Description
First published in 1995: Clinically Applied Microcirculation Research combines state-of-the-art microcirculation technology with present and potential applications in clinical medicine. This comprehensive guide unites the expertise of clinicians and basic researchers from around the world. Many of the chapters are authored by scientist/physician teams. The book provides a broad overview of how microcirculation is involved in clinical research. This is also a valuable reference source for both the history of and latest developments in microcirculation research.

Author: Konrad Reinhart
Publisher: Springer Science & Business Media
ISBN: 3642850367
Category : Medical
Languages : en
Pages : 573

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Book Description
The comprehensive coverage of the incidence, etiology, pathophysiology, definition, and therapy of sepsis and septic shock gives you the knowledge you need to keep up with modern therapeutic strategies. The authors are either basic scientists or clinical researchers whose goal is to present the newest aspects of their work in comprehensible language. They clearly show the new perspectives that are emerging in the treatment of sepsis and septic shock.