Author: G. C. King
Publisher:
ISBN:
Category : Amplifiers (Electronics)
Languages : en
Pages : 4

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Book Description

Author: Prashant Kesharwani
Publisher: Woodhead Publishing
ISBN: 0323855768
Category : Technology & Engineering
Languages : en
Pages : 558

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Book Description
Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers – such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy. - Reviews the mechanisms behind multi-drug resistance (MDR) in cancer and how aptamer-mediated novel therapeutic agents and strategies can facilitate MDR reversal - Covers a range of aptamers engineered nanostructures, including PLGA nanoparticles, silica nanoparticles, quantum dots, nucleic acid aptamers, and more - Discusses the challenges associated with using aptamers as cancer therapeutics and how this translates into clinical use

Author: Günter Mayer
Publisher: Humana
ISBN: 9781493931965
Category : Science
Languages : en
Pages : 0

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Book Description
This volume provides protocol references covering recent developments in the aptamer field. Within the last decade, aptamers have become more and more popular, and their sophisticated biophysical properties together with their ability to be easily modified and, thus, adapted to various regimens makes them a very promising class of compounds. Divided into three sections, the book covers selection, a series of analytical methods to assess biophysical properties of aptamer-target interactions, as well as various applications of aptamers. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and easy to follow, Nucleic Acid Aptamers: Selection, Characterization, and Application provides a state-of-the-art summary of recent developments in the aptamer field and will be a helpful resource for scientists in the life sciences working with aptamers as tools to elucidate biological systems.

Author: Kewal K. Jain
Publisher: Humana Press
ISBN: 1493969668
Category : Technology & Engineering
Languages : en
Pages : 661

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Book Description
Nanomedicine is defined as the application of nanobiotechnology in clinical medicine, which is currently being used to research the pathomechanism of disease, refine molecular diagnostics, and aid in the discovery, development, and delivery of drugs. In The Handbook of Nanomedicine, Third Edition, Prof. Kewal K. Jain updates, reorganizes, and replaces information in the comprehensive second edition in order to capture the most recent advances in this dynamic field. Important components of nanomedicine such as drug delivery via nanobiotechnology and nanopharmaceuticals as well as nanooncology, where the greatest number of advances are occurring, are covered extensively. As this text is aimed at nonmedical scientists, pharmaceutical personnel, as well as physicians, descriptions of the technology involved and other medical terminology are kept as clear and simple as possible. In depth and cutting-edge, The Handbook of Nanomedicine, Third Edition informs its readers of the ever-growing field of nanomedicine, destined to play a significant role in the future of healthcare.

Author: Tod W. Speer
Publisher: Lippincott Williams & Wilkins
ISBN: 1451153260
Category : Medical
Languages : en
Pages : 564

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Book Description
Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Author: Robert S. Marks
Publisher: CRC Press
ISBN: 9814364444
Category : Medical
Languages : en
Pages : 518

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Book Description
This book illustrates a variety of challenges that bug hunters try to solve. It is an outstanding collection of the insights and expertise of an interdisciplinary group of researchers from all walks of life: virologists, physicians, immunologists, electrochemists, physicists, computer scientists, biotechnologists, epidemiologists, and molecular bio

Author: Yiyang Dong
Publisher: Springer Nature
ISBN: 9813348380
Category : Science
Languages : en
Pages : 470

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Book Description
This book outlines comprehensively the main medical uses of aptamers, from diagnosis to therapeutics in fourteen chapters. Pioneering topics covered include aptamer pharmaceuticals, aptamers for malign tumors, aptamers for personalized therapeutics and aptamers for point-of-care testing. The book offers an essential guide for medical scientists interested in developing aptamer-based schemes for better theranostics. It is therefore of interest for not only academic researchers, but also practitioners and medical researchers in various fields of medical science, medical research and bio-analytical chemistry.

Author: Alexandru Mihai Grumezescu
Publisher: William Andrew
ISBN: 0128136669
Category : Science
Languages : en
Pages : 631

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Book Description
Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. - Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules - Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration - Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

Author:
Publisher: BoD – Books on Demand
ISBN: 0850141478
Category : Medical
Languages : en
Pages : 136

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Book Description
This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies. Key Features: • Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations • Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies • Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug– drug interactions, and toxicokinetics Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.

Author: Sougata Jana
Publisher: Springer
ISBN: 9811036470
Category : Medical
Languages : en
Pages : 457

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Book Description
The book focuses on novel particulate technologies for the purpose of drug delivery to humans. Nowadays, macro and nano-scale particles are being investigated for targeted delivery of small and large biological macromolecules. The targeting of drugs can minimize the dosage regimen and reduces dose related potential toxicity of drug molecules, which in turn lead to increased potential compliance. Various types of organic, inorganic and polymer particles are currently being investigated. These are attracting the attention of the research workers in the field of drug delivery science and technology. This book covers polymersomes, inorganic- organic composites, gold nanoparticles biopolymer and synthetic polymer particles etc.All aspects of drug delivery in relation to each technology have been described including these advances, Easy to read and understand the content of each chapter Rich in up-to-date information regarding their application.