Multidimensional Solid-state Nuclear Magnetic Resonance Spectroscopy of Pharmaceuticals and Polymers PDF Download

Author: Mark Thomas Zell
Publisher:
ISBN:
Category :
Languages : en
Pages : 432

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Author: Navnit Shah
Publisher: Springer
ISBN: 1493915983
Category : Medical
Languages : en
Pages : 702

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Book Description
This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.

Author: Klaus Schmidt-Rohr
Publisher: Elsevier
ISBN: 0080925626
Category : Science
Languages : en
Pages : 501

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Book Description
NMR spectroscopy is the most valuable and versatile analytical tool in chemistry. While excellent monographs exist on high-resolution NMR in liquids and solids, this is the first book to address multidimensional solid-state NMR. Multidimensional techniques enable researchers to obtain detailed information about the structure, dynamics, orientation, and phase separation of solids, which provides the basis of a better understanding of materials properties on the molecular level.Dramatic progress-much of it pioneered by the authors-has been achieved in this area, especially in synthetic polymers. Solid-state NMR now favorably competes with well-established techniques, such as light, x-ray, or neutron scattering, electron microscopy, and dielectric and mechanical relaxation.The application of multidimensional solid-state NMR inevitably involves use of concepts from different fields of science. This book also provides the first comprehensive treatment of both the new experimental techniques and the theoretical concepts needed in more complex data analysis. The text addresses spectroscopists and polymer scientists by treating the subject on different levels; descriptive, technical, and mathematical approaches are used when appropriate. It presents an overview of new developments with numerous experimental examples and illustrations, which will appeal to readers interested in both the information content as well as the potential of solid-state NMR. The book also contains many previously unpublished details that will be appreciated by those who want to perform the experiments. The techniques described are applicable not only to the study of synthetic polymers but to numerous problems in solid-state physics, chemistry, materials science, and biophysics. - Presents original theories and new perspectives on scattering techniques - Provides a systematic treatment of the whole subject - Gives readers access to previously unpublished material - Includes extensive illustrations

Author: Paul Hodgkinson
Publisher: Royal Society of Chemistry
ISBN: 1839163917
Category : Science
Languages : en
Pages : 299

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Book Description
Applications of nuclear magnetic resonance span a wide range of scientific disciplines, from physics to medicine. For those wanting to become acquainted with NMR or seasoned practitioners, this is a valuable source of current methods and applications.

Author: H.N. Cheng
Publisher: OUP USA
ISBN: 9780841226678
Category : Science
Languages : en
Pages : 0

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Book Description
Includes review and papers on the latest advances by acknowledged leaders and active researchers in nuclear magnetic resonance (NMR) spectroscopy

Author: Iwona Wawer
Publisher: Elsevier
ISBN: 008095152X
Category : Science
Languages : en
Pages : 525

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Book Description
For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples. Combines theory, techniques, and concrete applications—all of which closely resemble the laboratory experience Considers international pharmacopoeias, addressing the concern for licensing Features the work of academics and researchers, appealing to a broad readership

Author: The Nuclear Magnetic Resonance Society of Japan
Publisher: Springer
ISBN: 9811059667
Category : Science
Languages : en
Pages : 634

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Book Description
This book describes the advanced developments in methodology and applications of NMR spectroscopy to life science and materials science. Experts who are leaders in the development of new methods and applications of life and material sciences have contributed an exciting range of topics that cover recent advances in structural determination of biological and material molecules, dynamic aspects of biological and material molecules, and development of novel NMR techniques, including resolution and sensitivity enhancement. First, this book particularly emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of NMR spectroscopy. Second, the book is designed for those who are involved in either developing the technique or expanding the NMR application fields by applying them to specific samples. Third, the Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.

Author: Gareth A. Morris
Publisher: John Wiley & Sons
ISBN: 1118589084
Category : Science
Languages : en
Pages : 877

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Book Description
The content of this volume has been added to eMagRes (formerly Encyclopedia of Magnetic Resonance) - the ultimate online resource for NMR and MRI. The literature of multidimensional NMR began with the publication of three papers in 1975, then nine in 1976 and fifteen in 1977, and now contains many tens of thousands of papers. Any attempt to survey the field must therefore necessarily be very selective, not to say partial. In assembling this handbook, the Editors have sought to provide both the new researcher and the established scientist with a solid foundation for the understanding of multidimensional NMR, a representative if inevitably limited survey of its applications, an authoritative account of classic techniques such as COSY, NOESY and TOSCY, and an account of the latest progress in the development of multidimensional techniques. This handbook is structured in four parts. The first opens with an historical introduction to, and a brief account of, the practicalities and applications of multidimensional NMR methods, followed by a definitive survey of their conceptual basis and a series of articles setting out the generic principles of methods for acquiring and processing multidimensional NMR data. In the second part, the main families of multidimensional techniques, arranged in approximate order of increasing complexity, are described in detail, from simple J-resolved spectroscopy through to the powerful heteronuclear 3D and 4D methods that now dominate the study of structural biology in solution. The third part offers and illustrative selection from the very wide range of applications of multidimensional NMR methods, including some of the most recent developments in protein NMR. Finally, the fourth part introduces the idea of multidimensional spectra containing non-frequency dimensions, in which properties such as diffusion and relaxation are correlated. About EMR Handbooks / eMagRes Handbooks The Encyclopedia of Magnetic Resonance (up to 2012) and eMagRes (from 2013 onward) publish a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of EMR Handbooks / eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of articles from eMagRes. In consultation with the eMagRes Editorial Board, the EMR Handbooks / eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written (together with updates of some already existing articles) to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this Handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes View other eMagRes publications here

Author: G A Webb
Publisher: Royal Society of Chemistry
ISBN: 1847553826
Category : Science
Languages : en
Pages : 628

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Book Description
As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Author: Tawfik Abdo Saleh
Publisher: William Andrew
ISBN: 0128132957
Category : Technology & Engineering
Languages : en
Pages : 356

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Book Description
Polymer Hybrid Materials and Composites: Fundamentals and Applications presents an introduction to the principles behind polymeric hybrid materials, providing both theoretical and practical information on the synthesis and application of these materials. It documents the latest innovations, ranging from materials development and characterization of properties, to applications. Sections cover the route from laboratory to industry, providing practical, actionable guidance to assist the scaling up process for applications in areas including energy technology, solar cells, water purification, medical devices, optical and electrical devices, and more. It is an essential introduction to the emerging technologies that are made possible by these advanced materials. - Documents the latest innovations in the technology, thus enabling new applications - Provides significant and detailed information on the engineering of hybrid materials for a wide range of areas, including energy, medical, and electronics, among others