Author: Natasa PetronijevicPublisher: Frontiers Media SA
ISBN: 2889760952
Category : Medical
Languages : en
Pages : 147
Book Description
Modulation of NMDA Receptors: From Bench Side to Clinical Applications in Psychiatry
Author: Natasa PetronijevicPublisher: Frontiers Media SA
ISBN: 2889760952
Category : Medical
Languages : en
Pages : 147
Book Description
Pain Management and the Opioid Epidemic
Author: National Academies of Sciences, Engineering, and MedicinePublisher: National Academies Press
ISBN: 0309459575
Category : Medical
Languages : en
Pages : 483
Book Description
Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Cumulated Index Medicus
Author: Genes and Aging: From Bench Side to Bed side
Author: Wael M. Y. MohamedPublisher: Frontiers Media SA
ISBN: 2889749746
Category : Science
Languages : en
Pages : 121
Book Description
Ketamine for Treatment-Resistant Depression
Author: Sanjay J. MathewPublisher: Springer
ISBN: 3319429256
Category : Medical
Languages : en
Pages : 155
Book Description
This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.
Parkinson's Disease: Current and Future Therapeutics and Clinical Trials
Author: Néstor Gálvez-JiménezPublisher: Cambridge University Press
ISBN: 1107053862
Category : Medical
Languages : en
Pages : 385
Book Description
This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.
HUMAN METABOLISM OF ALCOHOL
Author: Kathryn E. CrowPublisher: CRC-Press
ISBN: 9780849345227
Category : Medical
Languages : en
Pages : 288
Book Description
This three-volume text provides a comprehensive review and reference source for those with a teaching, research, or practical involvement in alcohol metabolism in humans. Written by 70 contributing authors from 12 countries, this publication covers a wide range of material, from medicolegal aspects of alcohol metabolism to the structure of enzymes involved in metabolizing alcohol. Although primarily concerned with human alcohol metabolism, information from animal experiments is included where it clarifies results of human studies, or where information for human subjects is not available.
Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders
Author: Maurizio PopoliPublisher: Springer
ISBN: 1493910566
Category : Medical
Languages : en
Pages : 363
Book Description
Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.
Electroconvulsive and Neuromodulation Therapies
Author: Conrad M. SwartzPublisher: Cambridge University Press
ISBN: 1139478869
Category : Medical
Languages : en
Pages : 619
Book Description
Electroconvulsive therapy (ECT) is a psychiatric treatment involving the induction of a seizure through the transmission of electricity in the brain. Because of exploitation movies and greatly heightened drug company promotional activities ECT was used less frequently in the 1980s and 1990s. Eventually these movies were understood as unrealistic. Now these drugs are increasingly recognized as dangers to body health. Because of recent refinements and a far better scientific understanding of the clinical procedures and mechanisms underpinning ECT, this treatment modality has seen a resurgence in use and widespread appreciation of its safety. This book is the new definitive reference on electroconvulsive and neuromodulation therapies. It comprehensively covers the scientific basis and clinical practice of ECT as well as comparisons between ECT and medication therapies including the new generation of antipsychotic drugs. It also provides readers with administrative perspectives and specific details for the management of this modality in clinical practice. The new forms of nonconvulsive electrical and magnetic brain stimulation therapy are also covered in detail, in a separate section. The chapter authors are leading scholars and clinicians.
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