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Author: Dr. Shahid Sami Siddique Publisher: AG PUBLISHING HOUSE (AGPH Books) ISBN: 8119025768 Category : Study Aids Languages : en Pages : 270
Book Description
Modern pharmacology and toxicology is a branch of medicine, biology, and the pharmaceutical sciences that studies how drugs and medicines work. A drug can be any molecule, whether it's made in a lab, found in nature, or made by the body itself. To describe any species, either endogenous or foreign, that influences the biochemistry or physiology of a cell, tissue, organ, or organism, the term "pharmacon" is occasionally used. The study of interactions between living things and substances that influence both normal and aberrant biochemical activity is what it is known as in more particular terms. Pharmaceuticals are any compounds that may be used to treat or prevent disease. Toxicology is a field that draws from many other scientific disciplines, hence the work and interests of toxicologists span many areas. As we now know that all compounds may cause toxicity according to the exposure time and dosage, toxicologists are primarily interested in the mechanisms of action of various agents. Nonetheless, scientists are currently trying to determine the routes or endogenous molecules that are affected by even the most well-known and ancient substances, which results in toxicity.
Author: Dr. Shahid Sami Siddique Publisher: AG PUBLISHING HOUSE (AGPH Books) ISBN: 8119025768 Category : Study Aids Languages : en Pages : 270
Book Description
Modern pharmacology and toxicology is a branch of medicine, biology, and the pharmaceutical sciences that studies how drugs and medicines work. A drug can be any molecule, whether it's made in a lab, found in nature, or made by the body itself. To describe any species, either endogenous or foreign, that influences the biochemistry or physiology of a cell, tissue, organ, or organism, the term "pharmacon" is occasionally used. The study of interactions between living things and substances that influence both normal and aberrant biochemical activity is what it is known as in more particular terms. Pharmaceuticals are any compounds that may be used to treat or prevent disease. Toxicology is a field that draws from many other scientific disciplines, hence the work and interests of toxicologists span many areas. As we now know that all compounds may cause toxicity according to the exposure time and dosage, toxicologists are primarily interested in the mechanisms of action of various agents. Nonetheless, scientists are currently trying to determine the routes or endogenous molecules that are affected by even the most well-known and ancient substances, which results in toxicity.
Author: Alan Woolf Publisher: Academic Press ISBN: 0128222190 Category : Medical Languages : en Pages : 648
Book Description
History of Modern Clinical Toxicology describes the extraordinary advances in the practice of clinical toxicology within the past 70 years and brings together stories of the people – the champions of clinical toxicology - who contributed to these advances, discovered new therapies and antidotes, and made change happen. This book lays out the poison control system they built and the fascinating story of how they created a new and evolving medical specialty. With the participation of renowned international experts as authors, the book showcases the development of poison control centers around the world and the growth of the professional societies that represent and support them today. This book also tells the stories of the modern-day toxic disasters and recent toxic exposures that gained worldwide attention and notoriety. It outlines the public health responses to such calamities which have led to improvements in our understanding of the science and changes in public health policies and regulations to forestall future such events. Finally, the book covers key policies and agencies affecting poison control centers, addresses the challenges facing clinical toxicologists of today, and predicts advances and future innovations in the field. History of Modern Clinical Toxicology is a unique resource that provides the historical and international perspective that will help students, practitioners, scientists, and health policy makers put current issues and methods in perspective. It will help them understand how infrastructure and processes in clinical toxicology have evolved and why poison control systems are configured as they are. - Offers descriptions of the key regulatory advances affecting clinical toxicology - Provides synopses of modern-day poisoning disasters - Outlines the development of modern antidotes and future directions in clinical toxicology - Describes the origins and development of the U.S. poison control system - Includes the origins and features of professional clinical toxicology societies from around the world - Includes descriptions of the history of clinical toxicology and poison control in more than 35 countries
Author: Andreas Luch Publisher: Springer Science & Business Media ISBN: 3764383380 Category : Medical Languages : en Pages : 620
Book Description
Clinical Toxicology is the second volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.
Author: Philip C. Burcham Publisher: Springer Science & Business Media ISBN: 144715553X Category : Medical Languages : en Pages : 338
Book Description
This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text.
Author: Abialbon Paul Publisher: Springer Nature ISBN: 9813360097 Category : Medical Languages : en Pages : 1156
Book Description
This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.
Author: Ernest Hodgson Publisher: McGraw-Hill Medical Publishing ISBN: Category : Medical Languages : en Pages : 518
Book Description
This revised edition reflects changes in the core curriculum subjects covered in the basic toxicology course for graduate students. Designed as an introductory textbook, it emphasizes the fundamental basis of toxic action at the cellular and molecular levels and lays the foundation for specialized courses in toxicology. Additional topics include metabolic activation and cellular protection, clinical toxicology diagnosis and treatment, ecosystems, environmental toxicology, ecotoxicology, case histories, and future consideration for environmental and human health.
Author: Alan Kolok Publisher: Island Press ISBN: 1610913825 Category : Health & Fitness Languages : en Pages : 224
Book Description
Modern Poisons bridges the gap between traditional toxicology textbooks and journal articles on cutting-edge science. This accessible book explains basic principles in plain language while illuminating the most important issues in contemporary toxicology. Kolok begins by exploring age-old precepts such as the dose-response relationship and goes on to show exactly how chemicals enter the body and elicit their toxic effect. Kolok then traces toxicology's development, from studies of endocrine-disrupting chemicals in toiletries to the emerging science on prions and epigenetics. Whether studying toxicology itself, public health, or environmental science, readers will develop a core understanding of--and curiosity about--this fast-changing field.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309292492 Category : Medical Languages : en Pages : 107
Book Description
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Author: H. Rašková Publisher: Elsevier ISBN: 1483157202 Category : Medical Languages : en Pages : 113
Book Description
Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.
Author: Dr. Shahid Sami Siddique
Author: Dr. Shahid Sami Siddique
Author: Alan Woolf
Author: Andreas Luch
Author: Philip C. Burcham
Author: Abialbon Paul
Author: Ernest Hodgson
Author: P. Gopalakrishnakone
Author: Alan Kolok
Author: Institute of Medicine
Author: H. Rašková