Author: K.C. MarshallPublisher: Springer Science & Business Media
ISBN: 364270137X
Category : Science
Languages : en
Pages : 423
Book Description
Microbial Adhesion and Aggregation
Author: K.C. MarshallPublisher: Springer Science & Business Media
ISBN: 364270137X
Category : Science
Languages : en
Pages : 423
Book Description
Microbial Adhesion and Aggregation
Author: MICROBIAL ADHESION AND AGGREGATION.
Author: Microbial Adhesion and Aggregation
Author: K.C. MarshallPublisher: Springer
ISBN: 9783540139966
Category : Science
Languages : en
Pages : 426
Book Description
Microbial Aggregation
Author: CallejaPublisher: CRC Press
ISBN: 1351082973
Category : Science
Languages : en
Pages : 282
Book Description
This text covers in detail bacteria and yeasts, including an overall perspective of microbial aggregation as fundamental form and function, which is presented here to include systems still to be treated in detail.
Microbial Adhesion and Aggregation
Author: Microbial Adhesion to Surfaces
Author: R. C. W. BerkeleyPublisher:
ISBN:
Category : Adhesion
Languages : en
Pages : 566
Book Description
Microbial Biofilms
Author: Mahmoud GhannoumPublisher: John Wiley & Sons
ISBN: 1683673336
Category : Science
Languages : en
Pages : 608
Book Description
An examination of the research and translational application to prevent and treat biofilm-associated diseases In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense. Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically, Microbial Biofilms provides state-of-the-art research in the field of bacterial and fungal biofilms detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms future areas of research and their translational and clinical applications Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.
Bacterial Adhesion to Cells and Tissues
Author: Itzhak OfekPublisher: Springer Science & Business Media
ISBN: 1468464353
Category : Science
Languages : en
Pages : 585
Book Description
Attachment to host cells or tissues is often the first step in the establishment of bacterial infections. A complex array of recognition, attachment, and virulence factors is involved in this process, which recent research has greatly illuminated. This comprehensive and authoritative volume discusses the specific cell and tissue-specific affinities of pathogenic microorganisms, including bioinorganic surfaces such as teeth, and is an essential reference for researchers and students of host-pathogen interactions.
Molecular Insights Into Microbial Adhesion
Author: Roger Davies KleinPublisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 149
Book Description
Antibiotic-resistant bacterial infections are a serious and immediate threat to global public health. In the United States alone, over 2 million individuals develop antibiotic-resistant infections annually, resulting in 23,000 deaths and $20 billion in excess health care costs. Virulence factors that allow bacteria to invade and persist within the host are promising targets for novel antimicrobial agents that could be used to curb the spread of antibiotic resistance. Development of therapeutics that can selectively eliminate pathogenic bacteria while sparing the beneficial host microbiota requires a detailed molecular understanding of critical virulence factors that facilitate interactions between pathogens and their environments. Two such factors are Chaperone-Usher Pathway (CUP) pili, which mediate bacterial adhesion, and curli, which constitute the major extracellular matrix component of many biofilms. In this dissertation, I have elucidated the structure of two pilus adhesins thought to mediate colonization of the gastrointestinal tract and determined the mechanism of CsgE assembly factor function in curli biogenesis. CUP pili comprise hundreds of repeating structural subunits capped by an adhesin whose N-terminal lectin domain binds host receptors with stereochemical specificity, thus facilitating the colonization of specific host niches by Gram-negative bacteria. Using X-ray crystallography, I determined that the UclD adhesin on the F17-like pilus contains a transverse binding groove that binds O-glycans in the colonic crypts. Conversely, I found that the YehD adhesin contains a unique helix-loop-helix motif that can pivot open to reveal a deep hydrophobic pocket. Additional structural and genetic studies of the Yeh pilus rod reveal a tightly-wound right-handed helix that has maintained its biomechanical response to external force through purifying evolutionary selection. I have also utilized X-ray crystallography to elucidate the structure-activity relationship of high-affinity compounds that inhibit the binding of two additional pilus adhesins, FimH and FmlH, to the urinary tract during acute and chronic urinary tract infection. Finally, I have performed genetic and biochemical studies to elucidate the role of CsgE in bacterial biofilm formation. During curli biogenesis, I found that CsgE uses a series of specific and nonspecific electrostatic interactions to bind the major amyloid subunit CsgA and deliver it to the CsgG outer membrane pore, thus preventing premature aggregation and cellular toxicity. In aggregate, these findings have advanced our molecular understanding of bacterial adhesion during pathogenesis and illuminated novel pathways for the treatment of antibiotic-resistant infections.