Metallothionein III PDF Download

Author: Kazuo T. Suzuki
Publisher: Birkhauser
ISBN:
Category : Medical
Languages : en
Pages : 506

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Author: Astrid Sigel
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110434334
Category : Science
Languages : en
Pages : 596

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Book Description
Volume 17, entitled Lead: Its Effects on Environment and Health of the series Metal Ions in Life Sciences centers on the interrelations between biosystems and lead. The book provides an up-to-date review of the bioinorganic chemistry of this metal and its ions; it covers the biogeochemistry of lead, its use (not only as gasoline additive) and anthropogenic release into the environment, its cycling and speciation in the atmosphere, in waters, soils, and sediments, and also in mammalian organs. The analytical tools to determine and to quantify this toxic element in blood, saliva, urine, hair, etc. are described. The properties of lead(II) complexes formed with amino acids, peptides, proteins (including metallothioneins), nucleobases, nucleotides, nucleic acids, and other ligands of biological relevance are summarized for the solid state and for aqueous solutions as well. All this is important for obtaining a coherent picture on the properties of lead, its effects on plants and toxic actions on mammalian organs. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 17, which are written by 36 internationally recognized experts from 13 nations. The impact of this recently again vibrant research area is manifested in nearly 2000 references, over 50 tables and more than 100 illustrations (half in color). Lead: Its Effects on Environment and Health is an essential resource for scientists working in the wide range from material sciences, inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Author: Paolo Zatta
Publisher: World Scientific
ISBN: 9812778942
Category : Science
Languages : en
Pages : 335

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Book Description
Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

Author: J.H. Kägi
Publisher: Birkhäuser
ISBN: 3034867840
Category : Science
Languages : en
Pages : 723

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Author: Astrid Sigel
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110436272
Category : Science
Languages : en
Pages : 544

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These sulfur-rich chelators, being important in metal ion homeostasis, find increasing attention. MILS-5, written by 30 internationally recognized experts, focuses on this hot topic. The reader is supported by about 20 tables, more than 80 illustrations and nearly 2000 references. This book is an essential resource for scientists working in a wide range of disciplines from environmental toxicology and inorganic biochemistry all the way through to physiology and medicine.

Author: Michael Aschner
Publisher: CRC Press
ISBN: 1420039741
Category : Medical
Languages : en
Pages : 477

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Book Description
Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases.

Author:
Publisher: ScholarlyEditions
ISBN: 146493259X
Category : Medical
Languages : en
Pages : 83

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Book Description
Metalloproteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Metalloproteins in a concise format. The editors have built Metalloproteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Metalloproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Metalloproteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author: National Research Council Canada
Publisher: NRC Research Press
ISBN: 9780660164045
Category : Medical
Languages : en
Pages : 710

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Book Description
Presents papers from an international meeting of specialists from a variety of disciplines sharing an interest in trace elements. The papers are organized into broad categories covering such topics as trace element interactions in the food supply and nutrition; trace elements and genetic regulation; trace elements in pregnancy and lactation; assessment of trace element status; kinetic modelling; trace elements in the environment and food supply; trace elements, brain function, and behaviour; membrane function and cell signalling; analytical, experimental, and isotopic techniques; ethics of trace element research; defining trace element requirements of infants; trace element intervention studies; trace elements and animal production, free-radical mediated disease, and food and nutrition policy; analytical quality control; infection and immune function; trace element binding proteins; trace elements in growth and metabolism; mechanisms of trace element toxicity; and metabolic and physiological consequences of trace element deficiencies.

Author: Rudolfs K. Zalups
Publisher: CRC Press
ISBN: 9780748407989
Category : Medical
Languages : en
Pages : 608

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Book Description
Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology.

Author: Bibudhendra Sarkar
Publisher: Springer Science & Business Media
ISBN: 1461547237
Category : Medical
Languages : en
Pages : 395

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Book Description
During the past few years, major scientific discoveries have greatly contributed to our understanding of the relationship between metals and genetics. The fields which have contrib uted to this area range from Clinical Medicine and Genetics to Biochemistry and Chemistry. The aim of this book is to bring together investigators from these diverse fields to reflect on the broad implications of direct and indirect interactions of metals and genetic components. The volume begins with a tribute to the late Karen Wetterhahn, an outstanding scien tist in the field, who will be sadly missed by her friends and colleagues because of her un timely death. The book has 28 chapters contributed by scientists who are internationally known for their expertise and outstanding research. The subject matters are divided into five major sections. The first section discusses genetic response to environmental expo sure to metals. Potentially devastating health crises have been reported in recent years from several parts of the world, which stem from environmental exposure to metals. In this section, authors report their findings on the effects and influence of metals in gene ex pression and their consequences to human health. The section on metal carcinogenesis and metal caused DNA damage, presents the latest advances in our knowledge of the molecu lar mechanisms of metal-induced mutagenesis and carcinogenesis. This topic is at the very heart of our understanding of how cancer may be caused by various metals.