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Author: Mahbuba Rahman Publisher: Elsevier ISBN: 0443155275 Category : Science Languages : en Pages : 400
Book Description
Metabolomics for Personalized Vaccinology provides insight into the importance of personalized vaccines in the clinical and research environments. It explores the development of personalized vaccines, which requires in-depth knowledge of the patient's health status, particularly the immune system, and on metabolomics, the closest indicator of the disease phenotype. Specifically, the book provides an understanding of how metabolomics might be employed in personalized vaccinology and how the metabolic pathway of the host's system is altered by vaccine administration. Over the past few years, researchers have published articles on personalized vaccines, but these are sparse. Therefore, compiling information on this topic gives the reader an overview of the progress of the field, despite being at its infancy. Metabolomics for Personalized Vaccinology is ideally suited for researchers and postgraduate students who are interested in clinical and nonclinical studies where metabolites are used for the identification of disease and therapeutic targets. - Provides the principles of metabolomics and integration of other systems biology approach for personalized vaccine development - Discusses vaccine manufacturing technologies and importance of metabolomics for personalized vaccine development - Discusses the scope of personalized vaccine in relation to specific diseases - Possible scope of metabolomics in biomarker identification and vaccine discovery
Author: Mahbuba Rahman Publisher: Elsevier ISBN: 0443155275 Category : Science Languages : en Pages : 400
Book Description
Metabolomics for Personalized Vaccinology provides insight into the importance of personalized vaccines in the clinical and research environments. It explores the development of personalized vaccines, which requires in-depth knowledge of the patient's health status, particularly the immune system, and on metabolomics, the closest indicator of the disease phenotype. Specifically, the book provides an understanding of how metabolomics might be employed in personalized vaccinology and how the metabolic pathway of the host's system is altered by vaccine administration. Over the past few years, researchers have published articles on personalized vaccines, but these are sparse. Therefore, compiling information on this topic gives the reader an overview of the progress of the field, despite being at its infancy. Metabolomics for Personalized Vaccinology is ideally suited for researchers and postgraduate students who are interested in clinical and nonclinical studies where metabolites are used for the identification of disease and therapeutic targets. - Provides the principles of metabolomics and integration of other systems biology approach for personalized vaccine development - Discusses vaccine manufacturing technologies and importance of metabolomics for personalized vaccine development - Discusses the scope of personalized vaccine in relation to specific diseases - Possible scope of metabolomics in biomarker identification and vaccine discovery
Author: Kewal K. Jain Publisher: Springer Science & Business Media ISBN: 1441907696 Category : Medical Languages : en Pages : 443
Book Description
Personalized medicine, which simply means selection of treatment best suited for an individual, involves integration and translation of several new technologies in clinical care of patients. The scope is much broader than indicated by the term genomic medicine because many non-genomic factors are taken into consideration in developing personalized medicine. Basic technologies for personalized medicine, of which molecular diagnostics has the biggest share, are mentioned briefly and appropriate references are given for further information. Commercial aspects are discussed briefly in a chapter and detailed analysis of markets and companies involved in personalized medicine is presented in a special report on this topic. There is increasing interest in personalized medicine. Considerable advances have taken place in molecular biology and biotechnology to make personalized medicine a viable option, but some misconceptions still exist, both in the academic and commercial sectors. There is lack of a suitable source of information that provides both the fundamentals as well as applications of personalized medicine. As the latest version of the first monograph on personalized medicine published in 1998, this volume, Textbook of Personalized Medicine, summarizes the author’s efforts during the past decade, as well as reviews selected studies done during this period in a readable format for the physicians and scientists. It is hoped that physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge will find this book useful.
Author: Bhushan Patwardhan Publisher: Academic Press ISBN: 0128018224 Category : Medical Languages : en Pages : 482
Book Description
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. - Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned - Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines - Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery
Author: Vasso Apostolopoulos Publisher: Elsevier ISBN: 0443185654 Category : Medical Languages : en Pages : 530
Book Description
The role of vaccines is emerging and even critical to ending infectious and chronic diseases and pandemics alike. The design and development of new vaccines could lead to improved health. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Disease discusses these new developments and introduces the reader to the current state of the science and the outlook going forward from the discovery of vaccines to the clinical trials of personalized vaccines. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Diseases is a valuable reference for occupational health professionals whose role involves supervision of immunization programs such as those working in the National Health Service, some sectors of higher education and the pharmaceutical industry. - Offers comprehensive coverage of different vaccine platforms and their development - Includes information on the regulatory perspective of vaccine development - Describes different delivery approaches for vaccinology - Explains the clinical development of vaccines along with novel platforms - Covers all recent developments of vaccine production technologies, new types of vaccines, and ongoing research that could prevent future pandemics
Author: Surajbhan Sevda Publisher: Elsevier ISBN: 0443153795 Category : Science Languages : en Pages : 476
Book Description
Bioreactor Design Concepts for Viral Vaccine Production covers a range of interdisciplinary chapters from the engineering perspective of bioreactor design to the biotechnological perspectives of vector design for vaccine development. The book covers bioreactor concepts such as static systems, single-use systems, stirred tanks, perfusion, wave and packed-beds. It reviews options for efficient and economical production of human vaccines and discusses basic factors relevant for viral antigen production in mammalian cells, avian cells, and insect cells. This book will be a great resource for those interested in implemented novel bioreactor design or experimental schemes towards intensified or/and enhanced vaccine production. - Covers the fundamentals of bioreactor designs - Provides strategies for designing a successful vector-based vaccine - Discusses the applications of biological kinetics, thermodynamics and basic substrate requirements for viral vaccine production
Author: Muneeb U Rehman Publisher: Academic Press ISBN: 0323902510 Category : Medical Languages : en Pages : 427
Book Description
Clinical Applications of Immunogenetics: Immunogenetics: A Molecular and Clinical Overview, Volume II provides readers with an exclusive, updated overview of scientific knowledge, achievements and findings in the field of immunogenetics. In thirteen chapters, the book gives insights in new advancements and approaches in viral and autoimmune diseases. Specific chapters are dedicated to immunogenetic mechanisms in the treatment of immune disorders, cancer, neurological and neurodegenerative disorders. In addition, other chapters cover immunogenomics in precision medicine, clinical medicine and transplantation. Finally, a special chapter, COVID-19: A novel challenge to human immune-genetic machinery, updates on thoughts surrounding the pandemic. - Contains exclusive information about global research on immunogenetics - Provides a solid foundation to researchers wanting to work on immunogenetics and their application in different autoimmune, viral and infectious diseases - Delivers information in a meticulous, attractive manner using pictures, illustrations and tables - Gives insights into immunogenetics and its utility in therapeutics
Author: Trygve Tollefsbol Publisher: Elsevier ISBN: 0443238030 Category : Science Languages : en Pages : 782
Book Description
Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. - Includes new chapters on topics such as the limitations of personalized epigenetic variation comparisons; personalized epigenetics technologies; epigenetics of personalized nanomedicine; personalized epigenetic management of diabetes; epigenetics and chemoresistance; and personalized epigenetics and neurological disorders - Covers key methodological processes that are important in personalized medicine - Offers disease research case studies to provide in-depth discussion of examples of recent epigenetic research on a disease area - Features topics such as forensic epigenetics, epigenetics of personalized toxicity, limitations of epigenetic variation comparisons, and nanomedicine and nutrigenomics as applied to personalized epigenetics
Author: Harry F. Tibbals Publisher: CRC Press ISBN: 1351834142 Category : Medical Languages : en Pages : 549
Book Description
Considering the fluid nature of nano breakthroughs—and the delicate balance between benefits and consequences as they apply to medicine—readers at all levels require a practical, understandable base of information about these developments to take greatest advantage of them. Medical Nanotechnology and Nanomedicine meets that need by introducing non-experts to nanomedicine and its evolving organizational infrastructure. This practical reference investigates the impact of nanotechnology on applications in medicine and biomedical sciences, and the broader societal and economic effects. Eschewing technological details, it focuses on enhancing awareness of the business, regulatory, and administrative aspects of medical applications. It gives readers a critical, balanced, and realistic evaluation of existing nanomedicine developments and future prospects—an ideal foundation upon which to plan and make decisions. Covers the use of nanotechnology in medical applications including imaging, diagnosis and monitoring, drug delivery systems, surgery, tissue regeneration, and prosthetics Part of the Perspectives in Nanotechnology series—which contains broader coverage of the societal implications of nanotechnology—this book can be used as a standalone reference. Organized by historical perspective, current status, and future prospects, this powerful book: Explores background, definitions and terms, and recent trends and forces in nanomedicine Surveys the landscape of nanomedicine in government, academia, and the private sector Reviews projected future directions, capabilities, sustainability, and equity of nanomedicine, and choices to be made regarding its use Includes graphical illustrations, references, and keywords to reinforce concepts and aid further research In its assessment of alternative and sometimes conflicting concepts proposed for the application of nanotechnology to medicine, this book surveys major initiatives and the work of leading labs and innovators. It uses informative examples and case summaries to illustrate proven accomplishments and imagined possibilities in research and development.
Author: Mahbuba Rahman
Author: Mahbuba Rahman
Author: Kewal K. Jain
Author: Bhushan Patwardhan
Author: Vasso Apostolopoulos
Author: Surajbhan Sevda
Author: Ursula Wiedermann
Author: Muneeb U Rehman
Author: Trygve Tollefsbol
Author: Vipin M Vashishtha
Author: Harry F. Tibbals