Pesticide Biotransformation and Disposition PDF Download

Author: Ernest Hodgson
Publisher: Academic Press
ISBN: 0123854822
Category : Medical
Languages : en
Pages : 236

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Book Description
Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. - Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment - Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides - Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations

Author: Calvin M. Menzie
Publisher:
ISBN:
Category : Metabolism
Languages : en
Pages : 400

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Book Description
This publication supplements the preceding Metabolism of Pesticides (1969) and Metabolism of Pesticides - An Update (1974). Readers are also advised that, during the period from preparation to printing of this volume, a considerable additional literature on this subject matter has been published.

Author: Calvin M. Menzie
Publisher:
ISBN:
Category : Pesticides
Languages : en
Pages : 508

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Book Description
Disappearance of pesticides takes place by leaching, volatilization, adsorption, decompositino, or metabolism; and the use to which a particular pesticide is best suited may depend on the effects of one or more of these processes.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309166411
Category : Science
Languages : en
Pages : 226

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Book Description
The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.

Author: Calvin M. Menzie
Publisher:
ISBN:
Category : Pesticides
Languages : en
Pages : 748

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Book Description
This publication supplements its predecessors, Metabolism of Pesticides (1969), Metabolism of Pesticides -- An update (1974), and Metabolism of Pesticides -- Update 2 (1978).

Author: Calvin M. Menzie
Publisher:
ISBN:
Category : Pesticides
Languages : en
Pages : 522

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Book Description
In 1969 when Metabolism of Pesticides was published, it was still possible to condense the information into one volume. The continued growth of interest in the subject and the attendant volume of literature precluded such a condensation for the present volume. Consequently, this volume was prepared as an update and supplement. Readers are advised that a considerable body of literature may have been published during the time required to prepare and print the present volume.

Author: K.R.S. Rao
Publisher: Discovery Publishing House
ISBN: 9788171414796
Category : Fishes
Languages : en
Pages : 256

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Book Description
Contents: Introduction, Material and Methods, Independent and Combined Toxicity of Carbaryl and Phenthoate Determination of LC50 Values and Confirmation of Synergism, Some Observations and Physical, Morphological and Behavioural Changes in Channa Punctatus, Studies on Acetylcholinesterase, Studies on whole Animal and Tissue Respiration, Studies on Some Haematological Parameters, Studies on Some Aspects of Carbohydrate Metabolism, Studies on Some Aspects of Nitrogen Metabolism, General Discussion, Summary.

Author: J. Miyamoto
Publisher: Wiley-Blackwell
ISBN: 9780632022564
Category : Science
Languages : en
Pages : 128

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Book Description
One of the most difficult areas of toxicology is the extrapolation of results obtained from experimental animals to man. The common occurrence of species differences in a number of biological processes confounds this extapolation. The metabolism of pesticides, drugs and other foreign compounds is a very important determinant of their toxicological effects. An understanding of species differences in metabolism and the ability to predict or to study directly the metabolic fate of a pesticide in man therefore are of great value in the validation of animal models for man. This review is concerned with the factors affecting species differences in the metabolism of foreign compounds in experimental animals and man. Additionally, specific examples of the metabolism of pesticides, drugs and industrial chemicals in man are assessed and the approaches to the execution of metabolism studies in humans, proposed.

Author: Prabhat Kumar Srivastava
Publisher: John Wiley & Sons
ISBN: 1119432197
Category : Technology & Engineering
Languages : en
Pages : 312

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Book Description
A guide to the diversity of pesticides used in modern agricultural practices, and the relevant social and environmental issues Pesticides in Crop Production offers an important resource that explores pesticide action in plants; pesticide metabolism in soil microbes, plants and animals; bioaccumulation of pesticides and sensitiveness of microbiome towards pesticides. The authors explore pesticide risk assessment, the development of pesticide resistance in pests, microbial remediation of pesticide intoxicated legumes and pesticide toxicity amelioration in plants by plant hormones. The authors include information on eco-friendly pest management. They review the impact of pesticides on soil microorganism, crops and other plants along with the impact on other organisms like aquatic fauna and terrestrial animals including human beings. The book also contains an analysis of pesticide by GC-MS/MS (Gas Chromatography tandem Mass Spectrometry) a reliable method for the quantification and confirmation of multiclass pesticide residues. This important book: Offers a comprehensive guide to the use of the diversity of pesticides and the pertinent social and environmental issues Explores the impact of pesticides from morphological, anatomical, physiological and biochemical perspectives Shows how pesticides affects soil microorganisms, crops and other plants along with the impact on other organisms like aquatic fauna and animals Critically examines whether chemical pesticides are boon or bane and whether they can be replaced by environmental friendly pesticides Written for students, researchers and professionals in agriculture, botany, entomology and biotechnology, Pesticides in Crop Production examines the effects of chemical pesticides and the feasibility of using bio-pesticides.

Author: Terence Robert Roberts
Publisher: Royal Society of Chemistry
ISBN: 9780854044993
Category : Science
Languages : en
Pages : 1506

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Book Description
This important publication provides a comprehensive summary of data and information on the metabolism and chemical degradation of agrochemicals in soils, plants and animals. Part 1, Herbicides and Plant Growth Regulators, and Part 2, Insecticides and Fungicides, together provide a major bibliography, as each entry is fully referenced. Contents include metabolic products, pathways and mechanisms, together with useful details on physico-chemical properties and mode of action. Both parts are organised by class of chemical for easy reference. There are separate entries for each pesticide, covering most commercially available chemicals in use today. In addition, an overview of the metabolism of each major class provides the reader with an informed summary of key similarities and significant differences between individual chemicals. Information is based primarily on literature from the past 40 years of research, together with some important, previously unpublished work provided by the agrochemical companies. Presented in a systematic, easy-to-read style, with extensive indexing to facilitate the rapid location of required information and the comparison of related compounds, Metabolic Pathways of Agrochemicals is an invaluable reference for chemists, biochemists and biologists working in the discovery, development and registration of agrochemicals, as well as scientists in related areas such as design and mode of action of pharmaceuticals.