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Author: Mavis McCovey Publisher: ISBN: 9781597141178 Category : Biography & Autobiography Languages : en Pages : 343
Book Description
One of the few modern first-person accounts of Native American healers tells us about Indian life in this world and about life in the visionary medicine womans world. A compelling history.
Author: Mavis McCovey Publisher: ISBN: 9781597141178 Category : Biography & Autobiography Languages : en Pages : 343
Book Description
One of the few modern first-person accounts of Native American healers tells us about Indian life in this world and about life in the visionary medicine womans world. A compelling history.
Author: Alex M. Nading Publisher: Univ of California Press ISBN: 0520282620 Category : Medical Languages : en Pages : 287
Book Description
Dengue fever is the world’s most prevalent mosquito-borne illness, but Alex Nading argues that people in dengue-endemic communities do not always view humans and mosquitoes as mortal enemies. Drawing on two years of ethnographic research in urban Nicaragua and challenging current global health approaches to animal-borne illness, Mosquito Trails tells the story of a group of community health workers who struggle to come to terms with dengue epidemics amid poverty, political change, and economic upheaval. Blending theory from medical anthropology, political ecology, and science and technology studies, Nading develops the concept of “the politics of entanglement” to describe how Nicaraguans strive to remain alive to the world around them despite global health strategies that seek to insulate them from their environments. This innovative ethnography illustrates the continued significance of local environmental histories, politics, and household dynamics to the making and unmaking of a global pandemic.
Author: Mark Honigsbaum Publisher: Macmillan ISBN: 9780312421809 Category : History Languages : en Pages : 356
Book Description
Literally Italian for "bad air," malaria once plagued Rome, tropical trade routes and colonial ventures into India and South America and the disease has no known antidote aside from the therapeutic effects of the "miraculous" quinine. This first book from journalist Honigsbaum is a rousing history of the search for febrifuge or, more specifically, the rare red cinchona tree, the bark from which quinine is derived.
Author: National Research Council Publisher: National Academies Press ISBN: 030918651X Category : Medical Languages : en Pages : 163
Book Description
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309171148 Category : Medical Languages : en Pages : 221
Book Description
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Author: National Academies of Sciences, Engineering, and Medicine Publisher: National Academies Press ISBN: 0309494885 Category : Medical Languages : en Pages : 127
Book Description
Successful drug development relies on accurate and efficient clinical trials to deliver the best and most effective pharmaceuticals and clinical care to patients. However, the current model for clinical trials is outdated, inefficient and costly. Clinical trials are limited by small sample sizes that do not reflect variations among patients in the real world, financial burdens on participants, and slow processes, and these factors contribute to the disconnect between clinical research and clinical practice. On November 28-29, the National Academies of Sciences, Engineering, and Medicine convened a workshop to investigate the current clinical trials system and explore the potential benefits and challenges of implementing virtual clinical trials as an enhanced alternative for the future. This publication summarizes the presentations and discussions from the workshop.
Author: Michael L. Tate Publisher: University of Oklahoma Press ISBN: 0806160233 Category : History Languages : en Pages : 263
Book Description
In the years after the discovery of gold in California, thousands of fortune seekers made their way west, joining the greatest mass migration in American history. The gold fields were only one destination, as emigrants pushed across the Great Plains, Great Basin, and Oregon Territory in unprecedented numbers, following the Oregon, California, and Mormon Trails to the verdant Willamette Valley or Mormon settlements in the Salt Lake Valley. “Seeing the Elephant” they often called the journey, referring to the wondrous sights and endless adventures met along the way. The firsthand accounts of those who made the trip between 1850 and 1855 that are collected in this third volume in a four-part series speak of wonders and adventures, but also of disaster and deprivation. Traversing the ever-changing landscape, these pioneers braved flooded rivers, endured cholera and hunger, and had encounters with Indians that were often friendly and sometimes troubled. Rich in detail and diverse in the experiences they relate, these letters, diary excerpts, recollections, and reports capture the voices of women and men of all ages and circumstances, hailing from states far and wide, and heading west in hope and desperation. Their words allow us to see the grit and glory of the American West as it once appeared to those who witnessed its transformation. Michael L. Tate begins the volume with an introduction to this middle phase of the trails’ history. A headnote and annotations for each document sketch the author’s background and reasons for undertaking the trip and correct and clarify information in the original manuscript. The extensive bibliography identifies sources and suggests further reading.
Author: Mavis McCovey
Author: Mavis McCovey
Author: Marc Smith
Author: Marc Smith
Author: Alex M. Nading
Author: 
Author: Mark Honigsbaum
Author: National Research Council
Author: Institute of Medicine
Author: National Academies of Sciences, Engineering, and Medicine
Author: Michael L. Tate